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- W1996975556 endingPage "185" @default.
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- W1996975556 abstract "CALCIUM fulfills the requirements of an intracellular mediator for gonadotropin-releasing hormone (GnRH; pyro-Glu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-GIU-NH2)-stimulated gonadotropin release from the pituitary (1). Evidence from our laboratory and others now suggests that GnRH action may be divided into three sequential steps: 1) interaction of GnRH with a specific plasma membrane receptor; 2) mobilization of ionic calcium (Ca2+); and 3) expulsion of the contents of the gonadotropin secretory granule to the extracellular space. At present, considerable work remains to be done regarding the mechanism of Ca2+ mobilization in response to GnRH and its precise locus of action. This review describes experiments that led to the development of this model and summarizes recent progress. A. Introduction Early studies with hemipituitaries and pituitary slices (2) suggested that the ionic makeup of the incubation medium, especially with regard to Ca2+, influenced the release of pituitary hormones. These studies relied upon crude hypothalamic extracts instead of purified or synthetic GnRH and have been reviewed previously (3–6)." @default.
- W1996975556 created "2016-06-24" @default.
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- W1996975556 creator A5070097997 @default.
- W1996975556 creator A5085965613 @default.
- W1996975556 date "1981-04-01" @default.
- W1996975556 modified "2023-09-27" @default.
- W1996975556 title "Gonadotropin-Releasing Hormone Action in the Pituitary: A Three Step Mechanism*" @default.
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