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• W1996976928 endingPage "261" @default.
• W1996976928 startingPage "255" @default.
• W1996976928 abstract "The frequency of spontaneous action potentials of locus coeruleus neurons was recorded extracellularly in pontine slices of the rat brain. The adenosine 5′-triphosphate (ATP) analogues α,β-methylene ATP (α,β-meATP) and 2-methylthio ATP increased the firing rate with a similar potency, while uridine 5′-triphosphate (UTP) was inactive. Diadenosine 5′-pentaphosphate (Ap5A), diadenosine 5′-tetraphosphate (Ap4A) and diadenosine 5′-triphosphate (Ap3A) all facilitated the firing. When equimolar concentrations were compared, Ap5A had the largest effect followed by Ap4A and Ap3A. Suramin markedly inhibited responses to α,β-meATP and 2-methylthio ATP; the effect of Ap4A was only slightly depressed by suramin. Pyridoxalphosphate-6-azophenyl-2,4-disulfonic acid (PPADS) strongly antagonized α,β-meATP, but failed to alter the effects of 2-methylthio ATP and Ap4A. Reactive blue 2 weakly antagonized α,β-meATP and did not interfere with 2-methylthio ATP and Ap4A. Moreover, suramin depressed responses to (S)-α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) and N-methyl-d-aspartic acid (NMDA), but not to substance P. PPADS failed to affect the AMPA- and NMDA-induced increases in firing. Hence, locus coeruleus neurons may possess receptors for adenosine nucleotides (P2x and P2Y purinoceptors) and dinucleotides (P2D purinoceptors); receptors for uridine nucleotides (P2U purinoceptors or pyrimidinoceptors) are probably absent." @default.
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• W1996976928 date "1996-11-01" @default.
• W1996976928 modified "2023-09-26" @default.
• W1996976928 title "Pharmacological characterization of P2 purinoceptor types in rat locus coeruleus neurons" @default.
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• W1996976928 doi "https://doi.org/10.1016/s0014-2999(96)00612-7" @default.
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