FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1996985329> ?p ?o ?g. }

• W1996985329 endingPage "704" @default.
• W1996985329 startingPage "700" @default.
• W1996985329 abstract "Abstract Tricyclic antidepressants (TCAs) are among the first line treatments clinically recommended against neuropathic pain. However, the mechanism by which they alleviate pain is still unclear. Pharmacological and genetic approaches evidenced a critical role of delta‐opioid receptors (DORs) in the therapeutic action of chronic TCA treatment. It is however unclear whether mu‐opioid receptors (MORs) are also necessary to the pain‐relieving action of TCAs. The lack of highly selective MOR antagonists makes difficult to conclude based on pharmacological studies. In the present work, we thus used a genetic approach and compared mutant mice lacking MORs and their wild‐type littermates. The neuropathy was induced by unilateral sciatic nerve cuffing. The threshold for mechanical response was evaluated using von Frey filaments. MOR‐deficient mice displayed the same baseline for mechanical sensitivity as their wild‐type littermates. After sciatic nerve cuffing, both wild‐type and MOR‐deficient mice displayed an ipsilateral mechanical allodynia. After about 10 days of treatment, nortriptyline suppressed this allodynia in both wild‐type and MOR‐deficient mice. MORs are thus not critical for nortriptyline action against neuropathic pain. An acute injection of the DOR antagonist naltrindole induced a relapse of neuropathic allodynia in both wild‐type and MOR‐deficient mice, thus confirming the critical role of DORs in nortriptyline action. Moreover, morphine induced an acute analgesia in control and in neuropathic wild‐type mice, but was without effect in MOR‐deficient mice. While MORs are crucial for morphine action, they are not critical for nortriptyline action. Our results highlight the functional difference between DORs and MORs in mechanisms of pain relief." @default.
• W1996985329 created "2016-06-24" @default.
• W1996985329 creator A5031112700 @default.
• W1996985329 creator A5039811767 @default.
• W1996985329 creator A5041985407 @default.
• W1996985329 creator A5042148504 @default.
• W1996985329 creator A5056698035 @default.
• W1996985329 creator A5081465383 @default.
• W1996985329 creator A5085557999 @default.
• W1996985329 creator A5090012638 @default.
• W1996985329 date "2010-08-01" @default.
• W1996985329 modified "2023-10-18" @default.
• W1996985329 title "Mu-opioid receptors are not necessary for nortriptyline treatment of neuropathic allodynia" @default.
• W1996985329 cites W1843310492 @default.
• W1996985329 cites W1964191745 @default.
• W1996985329 cites W1970290447 @default.
• W1996985329 cites W1975845818 @default.
• W1996985329 cites W1992056759 @default.
• W1996985329 cites W1993532733 @default.
• W1996985329 cites W1994921565 @default.
• W1996985329 cites W1997476828 @default.
• W1996985329 cites W2003028048 @default.
• W1996985329 cites W2005869624 @default.
• W1996985329 cites W2008782942 @default.
• W1996985329 cites W2009185989 @default.
• W1996985329 cites W2012407109 @default.
• W1996985329 cites W2014790939 @default.
• W1996985329 cites W2017221863 @default.
• W1996985329 cites W2022976179 @default.
• W1996985329 cites W2033415874 @default.
• W1996985329 cites W2035133263 @default.
• W1996985329 cites W2040742820 @default.
• W1996985329 cites W2045436300 @default.
• W1996985329 cites W2050646098 @default.
• W1996985329 cites W2051746492 @default.
• W1996985329 cites W2053855385 @default.
• W1996985329 cites W2056353612 @default.
• W1996985329 cites W2068954505 @default.
• W1996985329 cites W2071289233 @default.
• W1996985329 cites W2073947022 @default.
• W1996985329 cites W2081226239 @default.
• W1996985329 cites W2083337588 @default.
• W1996985329 cites W2084190290 @default.
• W1996985329 cites W2084906226 @default.
• W1996985329 cites W2086139880 @default.
• W1996985329 cites W2086719493 @default.
• W1996985329 cites W2093869050 @default.
• W1996985329 cites W2094310013 @default.
• W1996985329 cites W2095416307 @default.
• W1996985329 cites W2109548019 @default.
• W1996985329 cites W2119617723 @default.
• W1996985329 cites W2131113697 @default.
• W1996985329 cites W2135934730 @default.
• W1996985329 cites W2138676765 @default.
• W1996985329 cites W2139170682 @default.
• W1996985329 cites W2166290557 @default.
• W1996985329 doi "https://doi.org/10.1016/j.ejpain.2009.11.014" @default.
• W1996985329 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4469366" @default.
• W1996985329 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20056557" @default.
• W1996985329 hasPublicationYear "2010" @default.
• W1996985329 type Work @default.
• W1996985329 sameAs 1996985329 @default.
• W1996985329 citedByCount "28" @default.
• W1996985329 countsByYear W19969853292012 @default.
• W1996985329 countsByYear W19969853292013 @default.
• W1996985329 countsByYear W19969853292014 @default.
• W1996985329 countsByYear W19969853292015 @default.
• W1996985329 countsByYear W19969853292016 @default.
• W1996985329 countsByYear W19969853292018 @default.
• W1996985329 countsByYear W19969853292019 @default.
• W1996985329 countsByYear W19969853292020 @default.
• W1996985329 countsByYear W19969853292022 @default.
• W1996985329 crossrefType "journal-article" @default.
• W1996985329 hasAuthorship W1996985329A5031112700 @default.
• W1996985329 hasAuthorship W1996985329A5039811767 @default.
• W1996985329 hasAuthorship W1996985329A5041985407 @default.
• W1996985329 hasAuthorship W1996985329A5042148504 @default.
• W1996985329 hasAuthorship W1996985329A5056698035 @default.
• W1996985329 hasAuthorship W1996985329A5081465383 @default.
• W1996985329 hasAuthorship W1996985329A5085557999 @default.
• W1996985329 hasAuthorship W1996985329A5090012638 @default.
• W1996985329 hasBestOaLocation W19969853293 @default.
• W1996985329 hasConcept C118552586 @default.
• W1996985329 hasConcept C126322002 @default.
• W1996985329 hasConcept C15490471 @default.
• W1996985329 hasConcept C170493617 @default.
• W1996985329 hasConcept C2777107010 @default.
• W1996985329 hasConcept C2777389121 @default.
• W1996985329 hasConcept C2777883359 @default.
• W1996985329 hasConcept C2777953665 @default.
• W1996985329 hasConcept C2778750930 @default.
• W1996985329 hasConcept C2779245659 @default.
• W1996985329 hasConcept C2779886867 @default.
• W1996985329 hasConcept C2780216858 @default.
• W1996985329 hasConcept C2780779033 @default.
• W1996985329 hasConcept C2780820201 @default.
• W1996985329 hasConcept C2781063702 @default.
• W1996985329 hasConcept C2781118164 @default.

• next