FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1996987167> ?p ?o ?g. }

• W1996987167 endingPage "519" @default.
• W1996987167 startingPage "511" @default.
• W1996987167 abstract "The unstructured C-terminal domain (CTD) of eukaryotic RNA polymerase II dynamically regulates the process of transcription by recruiting different factors to nascent mRNA through its multiple phosphorylation patterns. A newly discovered class of phosphatases, the human small C-terminal domain phosphatases (Scp's), specifically dephosphorylates phosphorylated Ser5 (phospho.Ser5) of the tandem heptad repeats of the CTD of RNA polymerase II. Scp's also function as transcription regulators that epigenetically silence the expression of specific neuronal genes, whose inactivation leads to neuronal stem cell differentiation. Small molecule inhibitors of Scp's will be valuable for elucidating their mechanism in nervous system development and can possibly offer new strategies to treat diseases related to neurodegeneration. Despite the difficulty in developing selective inhibitors of protein phosphatases, we have recognized a characteristic hydrophobic binding pocket adjacent to the active site in Scp's that may facilitate selective inhibition. In the present study, we successfully identified the first selective lead compound, rabeprazole, for the Scp/TFIIF-interacting CTD phosphatase (Fcp) family. The high-resolution crystal structure of rabeprazole-bound Scp1 showed that the compound indeed binds to the hydrophobic binding pocket. We further confirmed that rabeprazole only targets Scp's but not its close family members Fcp1 and Dullard or bacteriophage λ Ser/Thr phosphatase. Such specificity may prove important for In Vivo studies since accidental inhibition of Fcp1 or Dullard would result in cell malfunctions and even cell death." @default.
• W1996987167 created "2016-06-24" @default.
• W1996987167 creator A5003753665 @default.
• W1996987167 creator A5053958839 @default.
• W1996987167 creator A5064453660 @default.
• W1996987167 creator A5069528716 @default.
• W1996987167 creator A5077042443 @default.
• W1996987167 date "2011-02-24" @default.
• W1996987167 modified "2023-09-27" @default.
• W1996987167 title "Selective Inactivation of a Human Neuronal Silencing Phosphatase by a Small Molecule Inhibitor" @default.
• W1996987167 cites W105839754 @default.
• W1996987167 cites W1606267994 @default.
• W1996987167 cites W1803719049 @default.
• W1996987167 cites W1964301185 @default.
• W1996987167 cites W1965591721 @default.
• W1996987167 cites W1970220572 @default.
• W1996987167 cites W1970438229 @default.
• W1996987167 cites W1971337746 @default.
• W1996987167 cites W1986427733 @default.
• W1996987167 cites W1994394331 @default.
• W1996987167 cites W2000106654 @default.
• W1996987167 cites W2002057123 @default.
• W1996987167 cites W2008170886 @default.
• W1996987167 cites W2013908795 @default.
• W1996987167 cites W2019429295 @default.
• W1996987167 cites W2030401341 @default.
• W1996987167 cites W2032742580 @default.
• W1996987167 cites W2039141906 @default.
• W1996987167 cites W2040190285 @default.
• W1996987167 cites W2041708774 @default.
• W1996987167 cites W2050590451 @default.
• W1996987167 cites W2054525948 @default.
• W1996987167 cites W2060645336 @default.
• W1996987167 cites W2068522851 @default.
• W1996987167 cites W2071337049 @default.
• W1996987167 cites W2075918949 @default.
• W1996987167 cites W2079604571 @default.
• W1996987167 cites W2080796053 @default.
• W1996987167 cites W2104903709 @default.
• W1996987167 cites W2126873637 @default.
• W1996987167 cites W2154488281 @default.
• W1996987167 cites W2158022532 @default.
• W1996987167 cites W2160809006 @default.
• W1996987167 cites W2164273316 @default.
• W1996987167 doi "https://doi.org/10.1021/cb100357t" @default.
• W1996987167 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4814157" @default.
• W1996987167 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21348431" @default.
• W1996987167 hasPublicationYear "2011" @default.
• W1996987167 type Work @default.
• W1996987167 sameAs 1996987167 @default.
• W1996987167 citedByCount "36" @default.
• W1996987167 countsByYear W19969871672012 @default.
• W1996987167 countsByYear W19969871672013 @default.
• W1996987167 countsByYear W19969871672014 @default.
• W1996987167 countsByYear W19969871672015 @default.
• W1996987167 countsByYear W19969871672016 @default.
• W1996987167 countsByYear W19969871672017 @default.
• W1996987167 countsByYear W19969871672018 @default.
• W1996987167 countsByYear W19969871672019 @default.
• W1996987167 countsByYear W19969871672020 @default.
• W1996987167 countsByYear W19969871672021 @default.
• W1996987167 countsByYear W19969871672022 @default.
• W1996987167 crossrefType "journal-article" @default.
• W1996987167 hasAuthorship W1996987167A5003753665 @default.
• W1996987167 hasAuthorship W1996987167A5053958839 @default.
• W1996987167 hasAuthorship W1996987167A5064453660 @default.
• W1996987167 hasAuthorship W1996987167A5069528716 @default.
• W1996987167 hasAuthorship W1996987167A5077042443 @default.
• W1996987167 hasBestOaLocation W19969871672 @default.
• W1996987167 hasConcept C101762097 @default.
• W1996987167 hasConcept C104317684 @default.
• W1996987167 hasConcept C107824862 @default.
• W1996987167 hasConcept C11960822 @default.
• W1996987167 hasConcept C150194340 @default.
• W1996987167 hasConcept C161624437 @default.
• W1996987167 hasConcept C178666793 @default.
• W1996987167 hasConcept C55493867 @default.
• W1996987167 hasConcept C64350747 @default.
• W1996987167 hasConcept C86803240 @default.
• W1996987167 hasConcept C95444343 @default.
• W1996987167 hasConceptScore W1996987167C101762097 @default.
• W1996987167 hasConceptScore W1996987167C104317684 @default.
• W1996987167 hasConceptScore W1996987167C107824862 @default.
• W1996987167 hasConceptScore W1996987167C11960822 @default.
• W1996987167 hasConceptScore W1996987167C150194340 @default.
• W1996987167 hasConceptScore W1996987167C161624437 @default.
• W1996987167 hasConceptScore W1996987167C178666793 @default.
• W1996987167 hasConceptScore W1996987167C55493867 @default.
• W1996987167 hasConceptScore W1996987167C64350747 @default.
• W1996987167 hasConceptScore W1996987167C86803240 @default.
• W1996987167 hasConceptScore W1996987167C95444343 @default.
• W1996987167 hasIssue "5" @default.
• W1996987167 hasLocation W19969871671 @default.
• W1996987167 hasLocation W19969871672 @default.
• W1996987167 hasLocation W19969871673 @default.
• W1996987167 hasLocation W19969871674 @default.
• W1996987167 hasOpenAccess W1996987167 @default.
• W1996987167 hasPrimaryLocation W19969871671 @default.

• next