Matches in SemOpenAlex for { <https://semopenalex.org/work/W1996987912> ?p ?o ?g. }
- W1996987912 endingPage "898" @default.
- W1996987912 startingPage "891" @default.
- W1996987912 abstract "Replication-competent herpes simplex virus (HSV-1) mutants are used in clinical trials in the experimental treatment of cancer. Mutants G207, HSV1716, NV1020, and Oncovex GM-CSF share in common a defect in one or both copies of the gene encoding the neurovirulence factor, ICP34.5, and are thus neuroattenuated. These viruses are acknowledged to differ from one another (a) in the specific types of mutations intentionally introduced during their derivation and (b) in the inherent genetic differences retained from the different parent strains used in their construction. Unintended mutations are expected to emerge at some low frequency during the selection for and passage of mutant viruses. Here we demonstrate that during the construction of the oncolytic virus R3616, a nonsense mutation arose in an untargeted region of the HSV-1 genome that resulted in a substantial truncation of the viral protein known as UL3. This report is the first published documentation that oncolytic herpesviruses developed and used in clinical trials contain adventitious mutations. The implications of these findings for the characterization and development of vectors proposed for use in clinical trials are discussed." @default.
- W1996987912 created "2016-06-24" @default.
- W1996987912 creator A5000584150 @default.
- W1996987912 creator A5006406177 @default.
- W1996987912 creator A5016113087 @default.
- W1996987912 creator A5040497689 @default.
- W1996987912 date "2006-05-01" @default.
- W1996987912 modified "2023-09-23" @default.
- W1996987912 title "Oncolytic Viruses Derived from the γ34.5-Deleted Herpes Simplex Virus Recombinant R3616 Encode a Truncated UL3 Protein" @default.
- W1996987912 cites W1535327875 @default.
- W1996987912 cites W1567376454 @default.
- W1996987912 cites W1812947354 @default.
- W1996987912 cites W1865390700 @default.
- W1996987912 cites W1877134106 @default.
- W1996987912 cites W1915759986 @default.
- W1996987912 cites W1967380633 @default.
- W1996987912 cites W1970010476 @default.
- W1996987912 cites W1970212185 @default.
- W1996987912 cites W1976495611 @default.
- W1996987912 cites W1980477679 @default.
- W1996987912 cites W2000730289 @default.
- W1996987912 cites W2003152572 @default.
- W1996987912 cites W2005714906 @default.
- W1996987912 cites W2008393860 @default.
- W1996987912 cites W2015086123 @default.
- W1996987912 cites W2018535642 @default.
- W1996987912 cites W2018648852 @default.
- W1996987912 cites W2025335306 @default.
- W1996987912 cites W2026406742 @default.
- W1996987912 cites W2026842355 @default.
- W1996987912 cites W2033167442 @default.
- W1996987912 cites W2036103078 @default.
- W1996987912 cites W2037171350 @default.
- W1996987912 cites W2045415534 @default.
- W1996987912 cites W2056650797 @default.
- W1996987912 cites W2057382033 @default.
- W1996987912 cites W2079935861 @default.
- W1996987912 cites W2086996422 @default.
- W1996987912 cites W2087257698 @default.
- W1996987912 cites W2092952566 @default.
- W1996987912 cites W2097997319 @default.
- W1996987912 cites W2099648846 @default.
- W1996987912 cites W2113215587 @default.
- W1996987912 cites W2132191840 @default.
- W1996987912 cites W2135466315 @default.
- W1996987912 cites W2146223931 @default.
- W1996987912 cites W2149223196 @default.
- W1996987912 cites W2156472127 @default.
- W1996987912 cites W2157161479 @default.
- W1996987912 cites W2158343766 @default.
- W1996987912 cites W2162726569 @default.
- W1996987912 cites W2170613714 @default.
- W1996987912 cites W2171807420 @default.
- W1996987912 cites W2177087014 @default.
- W1996987912 doi "https://doi.org/10.1016/j.ymthe.2006.02.006" @default.
- W1996987912 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16574492" @default.
- W1996987912 hasPublicationYear "2006" @default.
- W1996987912 type Work @default.
- W1996987912 sameAs 1996987912 @default.
- W1996987912 citedByCount "28" @default.
- W1996987912 countsByYear W19969879122012 @default.
- W1996987912 countsByYear W19969879122013 @default.
- W1996987912 countsByYear W19969879122014 @default.
- W1996987912 countsByYear W19969879122015 @default.
- W1996987912 countsByYear W19969879122016 @default.
- W1996987912 countsByYear W19969879122017 @default.
- W1996987912 countsByYear W19969879122019 @default.
- W1996987912 countsByYear W19969879122021 @default.
- W1996987912 countsByYear W19969879122022 @default.
- W1996987912 crossrefType "journal-article" @default.
- W1996987912 hasAuthorship W1996987912A5000584150 @default.
- W1996987912 hasAuthorship W1996987912A5006406177 @default.
- W1996987912 hasAuthorship W1996987912A5016113087 @default.
- W1996987912 hasAuthorship W1996987912A5040497689 @default.
- W1996987912 hasBestOaLocation W19969879121 @default.
- W1996987912 hasConcept C104317684 @default.
- W1996987912 hasConcept C141231307 @default.
- W1996987912 hasConcept C143065580 @default.
- W1996987912 hasConcept C159047783 @default.
- W1996987912 hasConcept C2522874641 @default.
- W1996987912 hasConcept C2781196997 @default.
- W1996987912 hasConcept C501734568 @default.
- W1996987912 hasConcept C54355233 @default.
- W1996987912 hasConcept C82210918 @default.
- W1996987912 hasConcept C86803240 @default.
- W1996987912 hasConceptScore W1996987912C104317684 @default.
- W1996987912 hasConceptScore W1996987912C141231307 @default.
- W1996987912 hasConceptScore W1996987912C143065580 @default.
- W1996987912 hasConceptScore W1996987912C159047783 @default.
- W1996987912 hasConceptScore W1996987912C2522874641 @default.
- W1996987912 hasConceptScore W1996987912C2781196997 @default.
- W1996987912 hasConceptScore W1996987912C501734568 @default.
- W1996987912 hasConceptScore W1996987912C54355233 @default.
- W1996987912 hasConceptScore W1996987912C82210918 @default.
- W1996987912 hasConceptScore W1996987912C86803240 @default.
- W1996987912 hasIssue "5" @default.
- W1996987912 hasLocation W19969879121 @default.
- W1996987912 hasLocation W19969879122 @default.