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W1996990102 endingPage "7283" @default.
W1996990102 startingPage "7275" @default.
W1996990102 abstract "Excess reactive oxygen species (ROS) have been proved to damage cancer cells efficiently. ROS overproduction is thus greatly desirable for cancer therapy. To date, ROS production is generally uncontrollable and outside cells, which always bring severe side-effects in the vasculature. Since most ROS share a very short half-life and primarily react close to their site of formation, it would be more efficient if excess ROS are controllably produced inside cancer cells. Herein, we report an efficient lysosome-controlled ROS overproduction via a pH-responsive catalytic nanosystem (FeOx-MSNs), which catalyze the decomposition of H2O2 to produce considerable ROS selectively inside the acidic lysosomes (pH 5.0) of cancer cells. After a further incorporation of ROS-sensitive TMB into the nanosystem (FeOx-MSNs-TMB), both a distinct cell labeling and an efficient death of breast carcinoma cells are obtained. This lysosome-controlled efficient ROS overproduction suggests promising applications in cancer treatments." @default.
W1996990102 created "2016-06-24" @default.
W1996990102 creator A5008300440 @default.
W1996990102 creator A5034420463 @default.
W1996990102 creator A5045126800 @default.
W1996990102 creator A5048720333 @default.
W1996990102 date "2015-01-01" @default.
W1996990102 modified "2023-10-14" @default.
W1996990102 title "Lysosome-controlled efficient ROS overproduction against cancer cells with a high pH-responsive catalytic nanosystem" @default.
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W1996990102 doi "https://doi.org/10.1039/c5nr00706b" @default.
W1996990102 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25813671" @default.
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