FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1996994761> ?p ?o ?g. }

• W1996994761 endingPage "193" @default.
• W1996994761 startingPage "188" @default.
• W1996994761 abstract "The neoplastic cells in classical Hodgkin disease (Reed-Sternberg cells) are of B-lymphoid origin, but they lack many markers of this cell lineage, for example, immunoglobulin, CD20, and B-cell-associated transcription factors. In contrast, the neoplastic cells (L&H cells) in lymphocyte predominance Hodgkin disease retain the molecular profile of germinal center B cells. In this paper, we investigated the expression in Hodgkin disease (45 cases and 3 cell lines) of 5 intracellular signaling molecules found in B cells. The Src family kinase Syk, the B-cell adaptor protein BLNK, and phospholipase C (PLC)-gamma2 were consistently absent from Reed-Sternberg cells, whereas 2 other Src kinases (Lyn and Fyn) were heterogeneously expressed in a proportion of cases (12% and 42%, respectively). In contrast, the tumor cells in all cases of lymphocyte predominance Hodgkin disease were positive for Fyn, Syk, BLNK, and PLC-gamma2, and Lyn immunostaining was seen in a minority of biopsies. These results indicate that in Reed-Sternberg cells, the defect in B-cell lineage marker expression includes a spectrum of molecules involved in intracellular signaling, a finding in keeping with recent gene expression profiling studies. Furthermore, the clear difference in expression of signaling proteins between the 2 major subtypes of Hodgkin disease may be of diagnostic value." @default.
• W1996994761 created "2016-06-24" @default.
• W1996994761 creator A5001737873 @default.
• W1996994761 creator A5004848162 @default.
• W1996994761 creator A5031150987 @default.
• W1996994761 creator A5043985252 @default.
• W1996994761 creator A5057290942 @default.
• W1996994761 creator A5084391847 @default.
• W1996994761 date "2004-01-01" @default.
• W1996994761 modified "2023-10-16" @default.
• W1996994761 title "Expression of intracellular signaling molecules in classical and lymphocyte predominance Hodgkin disease" @default.
• W1996994761 cites W125310830 @default.
• W1996994761 cites W1554337334 @default.
• W1996994761 cites W1635630008 @default.
• W1996994761 cites W1922688703 @default.
• W1996994761 cites W1967555573 @default.
• W1996994761 cites W1968777478 @default.
• W1996994761 cites W1974010997 @default.
• W1996994761 cites W1974224187 @default.
• W1996994761 cites W1974654770 @default.
• W1996994761 cites W1977156769 @default.
• W1996994761 cites W1986150526 @default.
• W1996994761 cites W1994432856 @default.
• W1996994761 cites W2011443550 @default.
• W1996994761 cites W2019261082 @default.
• W1996994761 cites W2031780590 @default.
• W1996994761 cites W2034762925 @default.
• W1996994761 cites W2039490597 @default.
• W1996994761 cites W2043143911 @default.
• W1996994761 cites W2044802341 @default.
• W1996994761 cites W2045708448 @default.
• W1996994761 cites W2049074441 @default.
• W1996994761 cites W2055907134 @default.
• W1996994761 cites W2056343070 @default.
• W1996994761 cites W2066416336 @default.
• W1996994761 cites W2074436812 @default.
• W1996994761 cites W2078333884 @default.
• W1996994761 cites W2083929635 @default.
• W1996994761 cites W2086941505 @default.
• W1996994761 cites W2088549138 @default.
• W1996994761 cites W2090392995 @default.
• W1996994761 cites W2094126922 @default.
• W1996994761 cites W2095109339 @default.
• W1996994761 cites W2099566069 @default.
• W1996994761 cites W2129460662 @default.
• W1996994761 cites W2132600682 @default.
• W1996994761 cites W2133458484 @default.
• W1996994761 cites W2148152782 @default.
• W1996994761 cites W2153410622 @default.
• W1996994761 cites W2167681720 @default.
• W1996994761 cites W2171220871 @default.
• W1996994761 cites W23692696 @default.
• W1996994761 cites W2398456118 @default.
• W1996994761 cites W2419259075 @default.
• W1996994761 cites W564376973 @default.
• W1996994761 cites W96192748 @default.
• W1996994761 doi "https://doi.org/10.1182/blood-2003-05-1487" @default.
• W1996994761 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12881301" @default.
• W1996994761 hasPublicationYear "2004" @default.
• W1996994761 type Work @default.
• W1996994761 sameAs 1996994761 @default.
• W1996994761 citedByCount "64" @default.
• W1996994761 countsByYear W19969947612012 @default.
• W1996994761 countsByYear W19969947612013 @default.
• W1996994761 countsByYear W19969947612014 @default.
• W1996994761 countsByYear W19969947612015 @default.
• W1996994761 countsByYear W19969947612016 @default.
• W1996994761 countsByYear W19969947612017 @default.
• W1996994761 countsByYear W19969947612019 @default.
• W1996994761 countsByYear W19969947612020 @default.
• W1996994761 countsByYear W19969947612023 @default.
• W1996994761 crossrefType "journal-article" @default.
• W1996994761 hasAuthorship W1996994761A5001737873 @default.
• W1996994761 hasAuthorship W1996994761A5004848162 @default.
• W1996994761 hasAuthorship W1996994761A5031150987 @default.
• W1996994761 hasAuthorship W1996994761A5043985252 @default.
• W1996994761 hasAuthorship W1996994761A5057290942 @default.
• W1996994761 hasAuthorship W1996994761A5084391847 @default.
• W1996994761 hasBestOaLocation W19969947611 @default.
• W1996994761 hasConcept C142724271 @default.
• W1996994761 hasConcept C203014093 @default.
• W1996994761 hasConcept C2777761686 @default.
• W1996994761 hasConcept C2779134260 @default.
• W1996994761 hasConcept C2779338263 @default.
• W1996994761 hasConcept C2910914307 @default.
• W1996994761 hasConcept C2992779791 @default.
• W1996994761 hasConcept C502942594 @default.
• W1996994761 hasConcept C62478195 @default.
• W1996994761 hasConcept C71924100 @default.
• W1996994761 hasConcept C79879829 @default.
• W1996994761 hasConcept C86803240 @default.
• W1996994761 hasConcept C95444343 @default.
• W1996994761 hasConceptScore W1996994761C142724271 @default.
• W1996994761 hasConceptScore W1996994761C203014093 @default.
• W1996994761 hasConceptScore W1996994761C2777761686 @default.
• W1996994761 hasConceptScore W1996994761C2779134260 @default.
• W1996994761 hasConceptScore W1996994761C2779338263 @default.
• W1996994761 hasConceptScore W1996994761C2910914307 @default.

• next