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- W1997002018 abstract "Cationic polymers are the subject of intense research as non-viral gene delivery systems, due to their flexible properties, facile synthesis, robustness, and proven gene delivery efficiency. Nevertheless, low transfection efficiency and undesirable cytotoxicity remain the most challenging aspects of these cationic polymers. To overcome the disadvantages, various modifications have been made to improve their gene delivery efficacy. Among them, hydrophobic modifications of the cationic polymers are receiving more and more attention. Most studies have shown that incorporation of hydrophobic chains can improve gene delivery efficiency, mainly explained by hydrophobic interaction conferred to the resulting amphiphilic polycation derivatives and by the enhanced cellular uptake by the hydrophobic chains via the lipophilic cell membrane. This review discusses recent studies on the hydrophobic modifications of cationic polymers for gene delivery. The effects of the hydrophobic modifications are discussed in terms of critical issues in the gene delivery process, such as gene encapsulation, adsorption to cell membrane, serum inhibition, gene dissociation, cytotoxicity, and tissue-targeting. Moreover, various hydrophobic modifications of the main cationic polymeric gene carriers (polyethylenimine, chitosan, polylysine, etc.) are described with regards to the resulting gene delivery activity. The structure-function relationships discussed here provide important information and insight for the design of novel gene vectors." @default.
- W1997002018 created "2016-06-24" @default.
- W1997002018 creator A5010014056 @default.
- W1997002018 creator A5029357452 @default.
- W1997002018 creator A5074606109 @default.
- W1997002018 creator A5078201248 @default.
- W1997002018 date "2010-09-01" @default.
- W1997002018 modified "2023-10-02" @default.
- W1997002018 title "Hydrophobic modifications of cationic polymers for gene delivery" @default.
- W1997002018 cites W127336782 @default.
- W1997002018 cites W1963620372 @default.
- W1997002018 cites W1964731218 @default.
- W1997002018 cites W1967078049 @default.
- W1997002018 cites W1967516337 @default.
- W1997002018 cites W1969260614 @default.
- W1997002018 cites W1971753158 @default.
- W1997002018 cites W1973350289 @default.
- W1997002018 cites W1973370187 @default.
- W1997002018 cites W1974191744 @default.
- W1997002018 cites W1975930645 @default.
- W1997002018 cites W1976900316 @default.
- W1997002018 cites W1977097370 @default.
- W1997002018 cites W1977151611 @default.
- W1997002018 cites W1978496247 @default.
- W1997002018 cites W1979993551 @default.
- W1997002018 cites W1980311961 @default.
- W1997002018 cites W1985225194 @default.
- W1997002018 cites W1986157095 @default.
- W1997002018 cites W1987643254 @default.
- W1997002018 cites W1988651862 @default.
- W1997002018 cites W1992609344 @default.
- W1997002018 cites W1992998779 @default.
- W1997002018 cites W1993378568 @default.
- W1997002018 cites W1993460790 @default.
- W1997002018 cites W1999446173 @default.
- W1997002018 cites W1999758913 @default.
- W1997002018 cites W2000577212 @default.
- W1997002018 cites W2000844060 @default.
- W1997002018 cites W2001286327 @default.
- W1997002018 cites W2005521877 @default.
- W1997002018 cites W2010277922 @default.
- W1997002018 cites W2010312818 @default.
- W1997002018 cites W2010655750 @default.
- W1997002018 cites W2011930407 @default.
- W1997002018 cites W2014659193 @default.
- W1997002018 cites W2015247727 @default.
- W1997002018 cites W2017198124 @default.
- W1997002018 cites W2018894464 @default.
- W1997002018 cites W2019204220 @default.
- W1997002018 cites W2019631541 @default.
- W1997002018 cites W2021082805 @default.
- W1997002018 cites W2022407268 @default.
- W1997002018 cites W2023030395 @default.
- W1997002018 cites W2023454033 @default.
- W1997002018 cites W2025471675 @default.
- W1997002018 cites W2025739869 @default.
- W1997002018 cites W2029349973 @default.
- W1997002018 cites W2030862253 @default.
- W1997002018 cites W2031123577 @default.
- W1997002018 cites W2033063864 @default.
- W1997002018 cites W2036355644 @default.
- W1997002018 cites W2037595752 @default.
- W1997002018 cites W2038486659 @default.
- W1997002018 cites W2039577598 @default.
- W1997002018 cites W2041577133 @default.
- W1997002018 cites W2041667200 @default.
- W1997002018 cites W2043630370 @default.
- W1997002018 cites W2044341578 @default.
- W1997002018 cites W2045389022 @default.
- W1997002018 cites W2050221254 @default.
- W1997002018 cites W2050935737 @default.
- W1997002018 cites W2052622203 @default.
- W1997002018 cites W2052917835 @default.
- W1997002018 cites W2054470003 @default.
- W1997002018 cites W2059021376 @default.
- W1997002018 cites W2059570913 @default.
- W1997002018 cites W2067351320 @default.
- W1997002018 cites W2067675498 @default.
- W1997002018 cites W2071265021 @default.
- W1997002018 cites W2071842134 @default.
- W1997002018 cites W2073244815 @default.
- W1997002018 cites W2073325595 @default.
- W1997002018 cites W2073475680 @default.
- W1997002018 cites W2074445572 @default.
- W1997002018 cites W2077277811 @default.
- W1997002018 cites W2079716364 @default.
- W1997002018 cites W2080823739 @default.
- W1997002018 cites W2080827866 @default.
- W1997002018 cites W2081294651 @default.
- W1997002018 cites W2083100535 @default.
- W1997002018 cites W2083153731 @default.
- W1997002018 cites W2083851430 @default.
- W1997002018 cites W2084502805 @default.
- W1997002018 cites W2084674940 @default.
- W1997002018 cites W2085279970 @default.
- W1997002018 cites W2085479511 @default.
- W1997002018 cites W2086069830 @default.
- W1997002018 cites W2086718445 @default.