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- W1997008172 abstract "<h3>Objective</h3> To investigate the incidence of single and multiple basal cell carcinoma (BCC) lesions and associated risk factors. <h3>Design</h3> A prospective, population-based cohort study (from January 1, 1990, through December 31, 2007). <h3>Setting</h3> Two cohorts of 10 994 Dutch people, 55 years or older, were studied in 1990 (first cohort) and 1999 (second cohort). <h3>Patients</h3> Patients with BCC lesions were identified from the Dutch national pathology laboratories network, hospitals, and general practices. <h3>Main Outcome Measures</h3> The associations between determinants and single and multiple BCC lesions were studied by estimating odds ratios (ORs) and hazards ratios, using multivariate logistic regression and Andersen-Gill models, respectively. <h3>Results</h3> Of the eligible 10 820 cohort members, 524 (4.8%) had BCC, of whom 361 had single and 163 (31.1%) had multiple lesions. Age and red hair were significant risk factors for a first BCC lesion in a multivariate model. In the Andersen-Gill model, people who developed a first BCC lesion after 75.0 years of age were significantly less likely to develop multiple lesions (≥75.0 years adjusted OR, 0.58; 95% confidence interval [CI], 0.47-0.71). Red hair (adjusted OR, 1.43; 95% CI, 1.05-1.94), high educational level (1.42; 1.12-1.81), and a first BCC lesion located on the upper extremities (1.49; 1.02-2.15) were associated with a significantly increased risk of developing multiple lesions. <h3>Conclusion</h3> Patients who are relatively young at their first BCC diagnosis, those with red hair, those with higher socioeconomic status, and/or those with a BCC lesion on their upper extremities have a higher risk of developing multiple lesions and require closer follow-up over time." @default.
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- W1997008172 date "2010-08-01" @default.
- W1997008172 modified "2023-10-16" @default.
- W1997008172 title "Risk Factors for Single and Multiple Basal Cell Carcinomas" @default.
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- W1997008172 doi "https://doi.org/10.1001/archdermatol.2010.155" @default.
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