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- W1997011489 abstract "Abstract Chemorefractory ovarian cancer patients show extremely poor prognosis. Microtubule-stabilizing Taxol (paclitaxel) is a first-line treatment against ovarian cancer. Despite the close interplay between microtubules and cell adhesion, it remains unknown if chemoresistance alters the way cells adhere to their extracellular environment, a process critical for cancer metastasis. To investigate this, we isolated Taxol-resistant populations of OVCAR3 and SKOV3 ovarian cancer cell lines. Though Taxol-resistant cells neither effluxed more drug nor gained resistance to other chemotherapeutics, they did display increased microtubule dynamics. These changes in microtubule dynamics coincided with faster attachment rates and decreased adhesion strength, which correlated with increased surface β1-integrin expression and decreased focal adhesion formation, respectively. Adhesion strength correlated best with Taxol-sensitivity and was found to be independent of microtubule polymerization but dependent on focal adhesion kinase (FAK), which was up-regulated in Taxol-resistant cells. FAK inhibition also decreased microtubule dynamics to equal levels in both populations, indicating alterations in adhesive signaling are up-stream of microtubule dynamics. Taken together, this work demonstrates that Taxol-resistance dramatically alters how ovarian cancer cells adhere to their extracellular environment causing down-stream increases in microtubule dynamics, providing a therapeutic target that may improve prognosis by not only recovering drug sensitivity, but also decreasing metastasis." @default.
- W1997011489 created "2016-06-24" @default.
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- W1997011489 date "2015-04-17" @default.
- W1997011489 modified "2023-10-14" @default.
- W1997011489 title "Alterations in Ovarian Cancer Cell Adhesion Drive Taxol Resistance by Increasing Microtubule Dynamics in a FAK-dependent Manner" @default.
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- W1997011489 cites W1558532670 @default.
- W1997011489 cites W1751321717 @default.
- W1997011489 cites W1857799540 @default.
- W1997011489 cites W1954597686 @default.
- W1997011489 cites W1963639964 @default.
- W1997011489 cites W1971106165 @default.
- W1997011489 cites W1978422684 @default.
- W1997011489 cites W1979538859 @default.
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- W1997011489 cites W1982632347 @default.
- W1997011489 cites W1993988048 @default.
- W1997011489 cites W1997559135 @default.
- W1997011489 cites W1999626546 @default.
- W1997011489 cites W2002060477 @default.
- W1997011489 cites W2007421939 @default.
- W1997011489 cites W2012678565 @default.
- W1997011489 cites W2016603665 @default.
- W1997011489 cites W2018835423 @default.
- W1997011489 cites W2019961381 @default.
- W1997011489 cites W2021705436 @default.
- W1997011489 cites W2037339465 @default.
- W1997011489 cites W2040935952 @default.
- W1997011489 cites W2042384810 @default.
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- W1997011489 cites W2048209624 @default.
- W1997011489 cites W2048454522 @default.
- W1997011489 cites W2055397209 @default.
- W1997011489 cites W2058709588 @default.
- W1997011489 cites W2060850340 @default.
- W1997011489 cites W2065452679 @default.
- W1997011489 cites W2068320944 @default.
- W1997011489 cites W2068854353 @default.
- W1997011489 cites W2071359790 @default.
- W1997011489 cites W2072499623 @default.
- W1997011489 cites W2075301965 @default.
- W1997011489 cites W2075823443 @default.
- W1997011489 cites W2091729045 @default.
- W1997011489 cites W2093407516 @default.
- W1997011489 cites W2098518658 @default.
- W1997011489 cites W2100491916 @default.
- W1997011489 cites W2100926855 @default.
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- W1997011489 cites W2115954319 @default.
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- W1997011489 cites W2147194859 @default.
- W1997011489 cites W2148153432 @default.
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- W1997011489 cites W2167452086 @default.
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- W1997011489 doi "https://doi.org/10.1038/srep09529" @default.
- W1997011489 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4400875" @default.
- W1997011489 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25886093" @default.
- W1997011489 hasPublicationYear "2015" @default.
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