Matches in SemOpenAlex for { <https://semopenalex.org/work/W1997016180> ?p ?o ?g. }
- W1997016180 endingPage "5573" @default.
- W1997016180 startingPage "5568" @default.
- W1997016180 abstract "The four members of the ErbB family of receptor tyrosine kinases (RTKs) mediate a variety of cellular responses to epidermal growth factor (EGF)-like growth factors, and serve as a model for the generation of both diversity and specificity in RTK signaling. Previous studies indicate that receptor-receptor interactions figure prominently in signaling through ErbB receptors. In addition to a role in receptor kinase activation, ligand-induced ErbB receptor homo- and heterodimerization is thought to account for the diversity of biological responses stimulated by EGF-like growth factors. Since each receptor has the potential to couple to different complements of signaling pathways, EGF-like ligands specify cellular response by dictating which pairs of receptors become activated. More recently evidence has been uncovered for ligand discrimination by individual ErbB receptor dimers; receptors appear to realize which ligand is binding and differentially respond through autophosphorylation site usage. These observations indicate that ligand stimulation of RTKs is not generic, and point to another layer in the ErbB signal diversification mechanism. The mechanistic implications of ligand discrimination are discussed." @default.
- W1997016180 created "2016-06-24" @default.
- W1997016180 creator A5003530674 @default.
- W1997016180 creator A5023068548 @default.
- W1997016180 date "2000-11-20" @default.
- W1997016180 modified "2023-10-10" @default.
- W1997016180 title "Ligand discrimination by ErbB receptors: differential signaling through differential phosphorylation site usage" @default.
- W1997016180 cites W1601571585 @default.
- W1997016180 cites W1812775185 @default.
- W1997016180 cites W1870135658 @default.
- W1997016180 cites W1972172786 @default.
- W1997016180 cites W1972746601 @default.
- W1997016180 cites W1973905761 @default.
- W1997016180 cites W1975197610 @default.
- W1997016180 cites W1980980623 @default.
- W1997016180 cites W1981108516 @default.
- W1997016180 cites W1985720487 @default.
- W1997016180 cites W1994830329 @default.
- W1997016180 cites W1996073367 @default.
- W1997016180 cites W2001124278 @default.
- W1997016180 cites W2002127663 @default.
- W1997016180 cites W2006432848 @default.
- W1997016180 cites W2006752099 @default.
- W1997016180 cites W2008940139 @default.
- W1997016180 cites W2014111401 @default.
- W1997016180 cites W2016125507 @default.
- W1997016180 cites W2018917333 @default.
- W1997016180 cites W2019890837 @default.
- W1997016180 cites W2026040088 @default.
- W1997016180 cites W2031665308 @default.
- W1997016180 cites W2033414079 @default.
- W1997016180 cites W2034626992 @default.
- W1997016180 cites W2040142253 @default.
- W1997016180 cites W2051614379 @default.
- W1997016180 cites W2058586542 @default.
- W1997016180 cites W2058632374 @default.
- W1997016180 cites W2061776631 @default.
- W1997016180 cites W2070921472 @default.
- W1997016180 cites W2071033930 @default.
- W1997016180 cites W2077374035 @default.
- W1997016180 cites W2082706608 @default.
- W1997016180 cites W2096185220 @default.
- W1997016180 cites W2103530688 @default.
- W1997016180 cites W2106415942 @default.
- W1997016180 cites W2110422486 @default.
- W1997016180 cites W2111941775 @default.
- W1997016180 cites W2115332043 @default.
- W1997016180 cites W2123206362 @default.
- W1997016180 cites W2134517562 @default.
- W1997016180 cites W2140067862 @default.
- W1997016180 cites W2143651667 @default.
- W1997016180 cites W2157935840 @default.
- W1997016180 cites W2323767042 @default.
- W1997016180 doi "https://doi.org/10.1038/sj.onc.1203913" @default.
- W1997016180 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11114736" @default.
- W1997016180 hasPublicationYear "2000" @default.
- W1997016180 type Work @default.
- W1997016180 sameAs 1997016180 @default.
- W1997016180 citedByCount "88" @default.
- W1997016180 countsByYear W19970161802012 @default.
- W1997016180 countsByYear W19970161802013 @default.
- W1997016180 countsByYear W19970161802014 @default.
- W1997016180 countsByYear W19970161802015 @default.
- W1997016180 countsByYear W19970161802016 @default.
- W1997016180 countsByYear W19970161802017 @default.
- W1997016180 countsByYear W19970161802020 @default.
- W1997016180 countsByYear W19970161802021 @default.
- W1997016180 countsByYear W19970161802022 @default.
- W1997016180 countsByYear W19970161802023 @default.
- W1997016180 crossrefType "journal-article" @default.
- W1997016180 hasAuthorship W1997016180A5003530674 @default.
- W1997016180 hasAuthorship W1997016180A5023068548 @default.
- W1997016180 hasBestOaLocation W19970161801 @default.
- W1997016180 hasConcept C101544691 @default.
- W1997016180 hasConcept C11960822 @default.
- W1997016180 hasConcept C150109051 @default.
- W1997016180 hasConcept C170493617 @default.
- W1997016180 hasConcept C180361614 @default.
- W1997016180 hasConcept C23440912 @default.
- W1997016180 hasConcept C26375932 @default.
- W1997016180 hasConcept C2775960820 @default.
- W1997016180 hasConcept C2776362946 @default.
- W1997016180 hasConcept C2779251935 @default.
- W1997016180 hasConcept C2911166042 @default.
- W1997016180 hasConcept C42362537 @default.
- W1997016180 hasConcept C55493867 @default.
- W1997016180 hasConcept C62478195 @default.
- W1997016180 hasConcept C86803240 @default.
- W1997016180 hasConcept C95444343 @default.
- W1997016180 hasConcept C97029542 @default.
- W1997016180 hasConceptScore W1997016180C101544691 @default.
- W1997016180 hasConceptScore W1997016180C11960822 @default.
- W1997016180 hasConceptScore W1997016180C150109051 @default.
- W1997016180 hasConceptScore W1997016180C170493617 @default.
- W1997016180 hasConceptScore W1997016180C180361614 @default.
- W1997016180 hasConceptScore W1997016180C23440912 @default.
- W1997016180 hasConceptScore W1997016180C26375932 @default.
- W1997016180 hasConceptScore W1997016180C2775960820 @default.