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• W1997018082 endingPage "310" @default.
• W1997018082 startingPage "303" @default.
• W1997018082 abstract "The concentration of Ca2+ inside the lumen of endoplasmic reticulum (ER) regulates a vast array of spatiotemporally distinct cellular processes, from intracellular Ca2+ signals to intra-ER protein processing and cell death. This review summarises recent data on the mechanisms of luminal Ca2+-dependent regulation of Ca2+ release and uptake as well as ER regulation of cellular adaptive processes. In addition we discuss general biophysical properties of the ER membrane, as trans-endomembrane Ca2+ fluxes are subject to basic electrical forces, determined by factors such as the membrane potential of the ER and the ease with which Ca2+ fluxes are able to change this potential (i.e. the resistance of the ER membrane). Although these electrical forces undoubtedly play a fundamental role in shaping [Ca2+](ER) dynamics, at present there is very little direct experimental information about the biophysical properties of the ER membrane. Further studies of how intraluminal [Ca2+] is regulated, best carried out with direct measurements, are vital for understanding how Ca2+ orchestrates cell function. Direct monitoring of [Ca2+](ER) under conditions where the cytosolic [Ca2+] is known may also help to capture elusive biophysical information about the ER, such as the potential difference across the ER membrane." @default.
• W1997018082 created "2016-06-24" @default.
• W1997018082 creator A5031535677 @default.
• W1997018082 creator A5065549009 @default.
• W1997018082 creator A5083227570 @default.
• W1997018082 date "2005-09-01" @default.
• W1997018082 modified "2023-10-18" @default.
• W1997018082 title "Intraluminal calcium as a primary regulator of endoplasmic reticulum function" @default.
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