FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1997019712> ?p ?o ?g. }

• W1997019712 endingPage "1072" @default.
• W1997019712 startingPage "1066" @default.
• W1997019712 abstract "YM155, a small-molecule survivin suppressant, exhibits anti-tumor activities in vitro, in vivo and in clinical trials. However, the mechanism of YM155 action remains unclear. In this study, YM155 was administered to a panel of cell lines and the effects of YM155 on Bcl-2 family members were analyzed. Our results show that YM155 strikingly downregulates Mcl-1 in a broad spectrum of cancer cell lines and that the Mcl-1 modulation occurs at the transcriptional level, independently of survivin modulation or caspase activity. Furthermore, analysis of the contribution of Mcl-1 or survivin downregulation to YM155-induced cell death in vitro showed that knockdown of Mcl-1 sensitizes cells to YM155-induced cytotoxicity. Finally, our data demonstrate that downregulation of Mcl-1 by YM155 synergistically lowers the threshold of Bcl-2 family member inhibitor ABT-263-induced cell death. Our findings reveal a novel mechanism by which survivin-independent Mcl-1 suppression plays a critical role in YM155-mediated anti-tumor activities. YM155 treatment in combination with ABT-263 thus affords a new strategy for cancer treatment." @default.
• W1997019712 created "2016-06-24" @default.
• W1997019712 creator A5033004996 @default.
• W1997019712 creator A5065920653 @default.
• W1997019712 creator A5070452335 @default.
• W1997019712 creator A5076038162 @default.
• W1997019712 date "2011-11-01" @default.
• W1997019712 modified "2023-10-16" @default.
• W1997019712 title "Mcl-1 downregulation by YM155 contributes to its synergistic anti-tumor activities with ABT-263" @default.
• W1997019712 cites W1967479801 @default.
• W1997019712 cites W1977258127 @default.
• W1997019712 cites W1982254984 @default.
• W1997019712 cites W2009486785 @default.
• W1997019712 cites W2023652762 @default.
• W1997019712 cites W2026315306 @default.
• W1997019712 cites W2037249620 @default.
• W1997019712 cites W2049856484 @default.
• W1997019712 cites W2052276044 @default.
• W1997019712 cites W2057136548 @default.
• W1997019712 cites W2070152120 @default.
• W1997019712 cites W2073942032 @default.
• W1997019712 cites W2078374613 @default.
• W1997019712 cites W2080059014 @default.
• W1997019712 cites W2085419794 @default.
• W1997019712 cites W2102401722 @default.
• W1997019712 cites W2106390211 @default.
• W1997019712 cites W2125554513 @default.
• W1997019712 cites W2139533680 @default.
• W1997019712 cites W2143278431 @default.
• W1997019712 cites W2157897307 @default.
• W1997019712 cites W2161959295 @default.
• W1997019712 cites W2167494923 @default.
• W1997019712 cites W2168632005 @default.
• W1997019712 cites W2172124462 @default.
• W1997019712 doi "https://doi.org/10.1016/j.bcp.2011.07.064" @default.
• W1997019712 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21784061" @default.
• W1997019712 hasPublicationYear "2011" @default.
• W1997019712 type Work @default.
• W1997019712 sameAs 1997019712 @default.
• W1997019712 citedByCount "62" @default.
• W1997019712 countsByYear W19970197122012 @default.
• W1997019712 countsByYear W19970197122013 @default.
• W1997019712 countsByYear W19970197122014 @default.
• W1997019712 countsByYear W19970197122015 @default.
• W1997019712 countsByYear W19970197122016 @default.
• W1997019712 countsByYear W19970197122017 @default.
• W1997019712 countsByYear W19970197122018 @default.
• W1997019712 countsByYear W19970197122019 @default.
• W1997019712 countsByYear W19970197122020 @default.
• W1997019712 countsByYear W19970197122021 @default.
• W1997019712 countsByYear W19970197122022 @default.
• W1997019712 countsByYear W19970197122023 @default.
• W1997019712 crossrefType "journal-article" @default.
• W1997019712 hasAuthorship W1997019712A5033004996 @default.
• W1997019712 hasAuthorship W1997019712A5065920653 @default.
• W1997019712 hasAuthorship W1997019712A5070452335 @default.
• W1997019712 hasAuthorship W1997019712A5076038162 @default.
• W1997019712 hasConcept C104317684 @default.
• W1997019712 hasConcept C127561419 @default.
• W1997019712 hasConcept C173396325 @default.
• W1997019712 hasConcept C185592680 @default.
• W1997019712 hasConcept C190283241 @default.
• W1997019712 hasConcept C202751555 @default.
• W1997019712 hasConcept C207001950 @default.
• W1997019712 hasConcept C2775975398 @default.
• W1997019712 hasConcept C502942594 @default.
• W1997019712 hasConcept C54355233 @default.
• W1997019712 hasConcept C55493867 @default.
• W1997019712 hasConcept C81885089 @default.
• W1997019712 hasConcept C86803240 @default.
• W1997019712 hasConcept C95444343 @default.
• W1997019712 hasConceptScore W1997019712C104317684 @default.
• W1997019712 hasConceptScore W1997019712C127561419 @default.
• W1997019712 hasConceptScore W1997019712C173396325 @default.
• W1997019712 hasConceptScore W1997019712C185592680 @default.
• W1997019712 hasConceptScore W1997019712C190283241 @default.
• W1997019712 hasConceptScore W1997019712C202751555 @default.
• W1997019712 hasConceptScore W1997019712C207001950 @default.
• W1997019712 hasConceptScore W1997019712C2775975398 @default.
• W1997019712 hasConceptScore W1997019712C502942594 @default.
• W1997019712 hasConceptScore W1997019712C54355233 @default.
• W1997019712 hasConceptScore W1997019712C55493867 @default.
• W1997019712 hasConceptScore W1997019712C81885089 @default.
• W1997019712 hasConceptScore W1997019712C86803240 @default.
• W1997019712 hasConceptScore W1997019712C95444343 @default.
• W1997019712 hasIssue "9" @default.
• W1997019712 hasLocation W19970197121 @default.
• W1997019712 hasLocation W19970197122 @default.
• W1997019712 hasOpenAccess W1997019712 @default.
• W1997019712 hasPrimaryLocation W19970197121 @default.
• W1997019712 hasRelatedWork W178543369 @default.
• W1997019712 hasRelatedWork W2042500493 @default.
• W1997019712 hasRelatedWork W2051072959 @default.
• W1997019712 hasRelatedWork W2159271922 @default.
• W1997019712 hasRelatedWork W2165236433 @default.
• W1997019712 hasRelatedWork W2494327966 @default.
• W1997019712 hasRelatedWork W2793515347 @default.
• W1997019712 hasRelatedWork W2896214335 @default.

• next