Matches in SemOpenAlex for { <https://semopenalex.org/work/W1997029554> ?p ?o ?g. }
- W1997029554 endingPage "45" @default.
- W1997029554 startingPage "42" @default.
- W1997029554 abstract "Urocortin 2 (Ucn 2) is corticotropin-releasing factor (CRF) paralog that preferentially activates CRF2 receptors. Ucns exert CRF2-mediated cytoprotective effects against ischemia-reperfusion injury in cardiomyocytes. However, little is known regarding potential retinoprotective effects of Ucns despite the known presence of CRF family peptides and their receptors (predominantly CRF2α) in retina. Therefore, the present study investigated the effects of post-ischemic intravitreal Ucn 2 (2 nmol) administration on ischemia-induced retinal degeneration. Two-month-old rats were subjected to permanent bilateral common carotid artery occlusion, and their retinas were processed histologically after two weeks survival to determine the density of viable cells in the ganglion cell layer and the thickness of all retinal layers. In vehicle-treated subjects, carotid occlusion reduced retina thickness by approximately 60% as compared to sham-operated animals. In contrast, intraocular Ucn 2 treatment led to a marked amelioration of the retinal layers, and the thickness of all layers was significantly increased by 40% compared to ischemic vehicle-treated subjects. Ucn 2 treatment also increased the number of cells by 55% in the ganglion cell layer as compared to those from carotid-occluded retinas of vehicle-treated subjects. These findings suggest that intraocular Ucn 2 treatment may protect against ischemia-induced retinal degeneration, results with potential therapeutic implications for ophthalmic diseases." @default.
- W1997029554 created "2016-06-24" @default.
- W1997029554 creator A5001234489 @default.
- W1997029554 creator A5005880385 @default.
- W1997029554 creator A5012145031 @default.
- W1997029554 creator A5015188454 @default.
- W1997029554 creator A5032952822 @default.
- W1997029554 creator A5038780695 @default.
- W1997029554 creator A5040818742 @default.
- W1997029554 creator A5057220825 @default.
- W1997029554 creator A5068138460 @default.
- W1997029554 creator A5080851208 @default.
- W1997029554 date "2009-05-01" @default.
- W1997029554 modified "2023-10-16" @default.
- W1997029554 title "Urocortin 2 protects against retinal degeneration following bilateral common carotid artery occlusion in the rat" @default.
- W1997029554 cites W1558522787 @default.
- W1997029554 cites W1966577838 @default.
- W1997029554 cites W1972680803 @default.
- W1997029554 cites W1991421292 @default.
- W1997029554 cites W1993729770 @default.
- W1997029554 cites W1997202195 @default.
- W1997029554 cites W2002844385 @default.
- W1997029554 cites W2007528115 @default.
- W1997029554 cites W2008833406 @default.
- W1997029554 cites W2013432169 @default.
- W1997029554 cites W2022138356 @default.
- W1997029554 cites W2026561698 @default.
- W1997029554 cites W2035437410 @default.
- W1997029554 cites W2040550641 @default.
- W1997029554 cites W2042223610 @default.
- W1997029554 cites W2046013541 @default.
- W1997029554 cites W2048166634 @default.
- W1997029554 cites W2054420798 @default.
- W1997029554 cites W2055926767 @default.
- W1997029554 cites W2059306365 @default.
- W1997029554 cites W2072939316 @default.
- W1997029554 cites W2073535343 @default.
- W1997029554 cites W2074396028 @default.
- W1997029554 cites W2085277476 @default.
- W1997029554 cites W2085434507 @default.
- W1997029554 cites W2088218868 @default.
- W1997029554 cites W2089037015 @default.
- W1997029554 cites W2090557381 @default.
- W1997029554 cites W2094465249 @default.
- W1997029554 cites W2094654990 @default.
- W1997029554 cites W2094761028 @default.
- W1997029554 cites W2094853228 @default.
- W1997029554 cites W2095646540 @default.
- W1997029554 cites W2096809080 @default.
- W1997029554 cites W2099060458 @default.
- W1997029554 cites W2103666037 @default.
- W1997029554 cites W2111794244 @default.
- W1997029554 cites W2117071187 @default.
- W1997029554 cites W2127921520 @default.
- W1997029554 cites W2131332924 @default.
- W1997029554 cites W2150290300 @default.
- W1997029554 cites W2170852425 @default.
- W1997029554 cites W4245960630 @default.
- W1997029554 doi "https://doi.org/10.1016/j.neulet.2009.03.013" @default.
- W1997029554 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19429103" @default.
- W1997029554 hasPublicationYear "2009" @default.
- W1997029554 type Work @default.
- W1997029554 sameAs 1997029554 @default.
- W1997029554 citedByCount "18" @default.
- W1997029554 countsByYear W19970295542012 @default.
- W1997029554 countsByYear W19970295542013 @default.
- W1997029554 countsByYear W19970295542014 @default.
- W1997029554 countsByYear W19970295542015 @default.
- W1997029554 countsByYear W19970295542016 @default.
- W1997029554 countsByYear W19970295542018 @default.
- W1997029554 countsByYear W19970295542019 @default.
- W1997029554 countsByYear W19970295542021 @default.
- W1997029554 countsByYear W19970295542022 @default.
- W1997029554 crossrefType "journal-article" @default.
- W1997029554 hasAuthorship W1997029554A5001234489 @default.
- W1997029554 hasAuthorship W1997029554A5005880385 @default.
- W1997029554 hasAuthorship W1997029554A5012145031 @default.
- W1997029554 hasAuthorship W1997029554A5015188454 @default.
- W1997029554 hasAuthorship W1997029554A5032952822 @default.
- W1997029554 hasAuthorship W1997029554A5038780695 @default.
- W1997029554 hasAuthorship W1997029554A5040818742 @default.
- W1997029554 hasAuthorship W1997029554A5057220825 @default.
- W1997029554 hasAuthorship W1997029554A5068138460 @default.
- W1997029554 hasAuthorship W1997029554A5080851208 @default.
- W1997029554 hasConcept C105702510 @default.
- W1997029554 hasConcept C118487528 @default.
- W1997029554 hasConcept C126322002 @default.
- W1997029554 hasConcept C134018914 @default.
- W1997029554 hasConcept C169760540 @default.
- W1997029554 hasConcept C170493617 @default.
- W1997029554 hasConcept C2776268601 @default.
- W1997029554 hasConcept C2776449918 @default.
- W1997029554 hasConcept C2777093970 @default.
- W1997029554 hasConcept C2777624874 @default.
- W1997029554 hasConcept C2780188069 @default.
- W1997029554 hasConcept C2780827179 @default.
- W1997029554 hasConcept C2781040256 @default.
- W1997029554 hasConcept C2781334511 @default.