FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1997037720> ?p ?o ?g. }

• W1997037720 endingPage "389" @default.
• W1997037720 startingPage "379" @default.
• W1997037720 abstract "The histological and biochemical differences between ethanol- and phenobarbital (PB)-potentiated hepatotoxicity of trichloroethylene (TRI) in Wistar strain male rats were investigated. Both ethanol (2 g in daily liquid diet for 3 weeks) and PB (80 mg/kg/day for 4 days, ip) pretreatments enhanced TRI (inhalation exposures of 500 ppm for 8 hr, 2000 ppm for 2 or 8 hr, and 8000 ppm for 2 hr)-induced hepatic damage as judged by increases in plasma transaminase activities. Livers from PB-treated rats exposed to TRI displayed centrilobular necrosis, whereas livers from ethanol-treated rats exposed to TRI were characterized by ballooning degeneration mainly in midzonal areas. TRI exposure decreased the in vitro metabolism of TRI, high-Km benzene aromatic hydroxylase (BAH) activity, and cytochrome P450 content in livers of PB-treated rats with severe hepatic damage. In ethanol-treated rats, TRI exposure increased both the in vitro metabolism of TRI and the low-Km BAH activity but did not cause an apparent decrease in cytochrome P450 content even in animals with severe hepatic damage. These results suggest that TRI caused necrosis of centrilobular hepatocytes in PB-pretreated rats, which was accompanied by loss of xenobiotic metabolizing functions, whereas ballooning degeneration of hepatocytes mainly in midzonal areas occurred in ethanol-pretreated rats without loss of xenobiotic metabolizing functions." @default.
• W1997037720 created "2016-06-24" @default.
• W1997037720 creator A5006153455 @default.
• W1997037720 creator A5041451157 @default.
• W1997037720 creator A5047794729 @default.
• W1997037720 date "1991-05-01" @default.
• W1997037720 modified "2023-10-02" @default.
• W1997037720 title "Morphological and biochemical analyses of trichloroethylene hepatotoxicity: Differences in ethanol- and phenobarbital-pretreated rats" @default.
• W1997037720 cites W1491419518 @default.
• W1997037720 cites W1775749144 @default.
• W1997037720 cites W1951469402 @default.
• W1997037720 cites W1963964449 @default.
• W1997037720 cites W1976448789 @default.
• W1997037720 cites W1980277775 @default.
• W1997037720 cites W2005002704 @default.
• W1997037720 cites W2006720511 @default.
• W1997037720 cites W2017141644 @default.
• W1997037720 cites W2031889994 @default.
• W1997037720 cites W2036831950 @default.
• W1997037720 cites W2042002086 @default.
• W1997037720 cites W2046400188 @default.
• W1997037720 cites W2065462331 @default.
• W1997037720 cites W2066073235 @default.
• W1997037720 cites W2068111218 @default.
• W1997037720 doi "https://doi.org/10.1016/0041-008x(91)90084-r" @default.
• W1997037720 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2020965" @default.
• W1997037720 hasPublicationYear "1991" @default.
• W1997037720 type Work @default.
• W1997037720 sameAs 1997037720 @default.
• W1997037720 citedByCount "31" @default.
• W1997037720 countsByYear W19970377202012 @default.
• W1997037720 countsByYear W19970377202014 @default.
• W1997037720 countsByYear W19970377202018 @default.
• W1997037720 countsByYear W19970377202022 @default.
• W1997037720 countsByYear W19970377202023 @default.
• W1997037720 crossrefType "journal-article" @default.
• W1997037720 hasAuthorship W1997037720A5006153455 @default.
• W1997037720 hasAuthorship W1997037720A5041451157 @default.
• W1997037720 hasAuthorship W1997037720A5047794729 @default.
• W1997037720 hasConcept C107872376 @default.
• W1997037720 hasConcept C115448650 @default.
• W1997037720 hasConcept C126322002 @default.
• W1997037720 hasConcept C134018914 @default.
• W1997037720 hasConcept C140027455 @default.
• W1997037720 hasConcept C178790620 @default.
• W1997037720 hasConcept C181199279 @default.
• W1997037720 hasConcept C185592680 @default.
• W1997037720 hasConcept C195289149 @default.
• W1997037720 hasConcept C2778793413 @default.
• W1997037720 hasConcept C2779404209 @default.
• W1997037720 hasConcept C2779864607 @default.
• W1997037720 hasConcept C2780161600 @default.
• W1997037720 hasConcept C29730261 @default.
• W1997037720 hasConcept C503630168 @default.
• W1997037720 hasConcept C526171541 @default.
• W1997037720 hasConcept C55493867 @default.
• W1997037720 hasConcept C62231903 @default.
• W1997037720 hasConcept C71924100 @default.
• W1997037720 hasConcept C86803240 @default.
• W1997037720 hasConcept C89311334 @default.
• W1997037720 hasConceptScore W1997037720C107872376 @default.
• W1997037720 hasConceptScore W1997037720C115448650 @default.
• W1997037720 hasConceptScore W1997037720C126322002 @default.
• W1997037720 hasConceptScore W1997037720C134018914 @default.
• W1997037720 hasConceptScore W1997037720C140027455 @default.
• W1997037720 hasConceptScore W1997037720C178790620 @default.
• W1997037720 hasConceptScore W1997037720C181199279 @default.
• W1997037720 hasConceptScore W1997037720C185592680 @default.
• W1997037720 hasConceptScore W1997037720C195289149 @default.
• W1997037720 hasConceptScore W1997037720C2778793413 @default.
• W1997037720 hasConceptScore W1997037720C2779404209 @default.
• W1997037720 hasConceptScore W1997037720C2779864607 @default.
• W1997037720 hasConceptScore W1997037720C2780161600 @default.
• W1997037720 hasConceptScore W1997037720C29730261 @default.
• W1997037720 hasConceptScore W1997037720C503630168 @default.
• W1997037720 hasConceptScore W1997037720C526171541 @default.
• W1997037720 hasConceptScore W1997037720C55493867 @default.
• W1997037720 hasConceptScore W1997037720C62231903 @default.
• W1997037720 hasConceptScore W1997037720C71924100 @default.
• W1997037720 hasConceptScore W1997037720C86803240 @default.
• W1997037720 hasConceptScore W1997037720C89311334 @default.
• W1997037720 hasIssue "3" @default.
• W1997037720 hasLocation W19970377201 @default.
• W1997037720 hasLocation W19970377202 @default.
• W1997037720 hasOpenAccess W1997037720 @default.
• W1997037720 hasPrimaryLocation W19970377201 @default.
• W1997037720 hasRelatedWork W1866176581 @default.
• W1997037720 hasRelatedWork W1997037720 @default.
• W1997037720 hasRelatedWork W2001097726 @default.
• W1997037720 hasRelatedWork W2007248155 @default.
• W1997037720 hasRelatedWork W2020953047 @default.
• W1997037720 hasRelatedWork W2023591078 @default.
• W1997037720 hasRelatedWork W2408203271 @default.
• W1997037720 hasRelatedWork W2950588997 @default.
• W1997037720 hasRelatedWork W4231093082 @default.
• W1997037720 hasRelatedWork W4308188252 @default.
• W1997037720 hasVolume "108" @default.
• W1997037720 isParatext "false" @default.

• next