FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1997042214> ?p ?o ?g. }

• W1997042214 endingPage "1261" @default.
• W1997042214 startingPage "1249" @default.
• W1997042214 abstract "Estrogen receptors α (ERα) and β (ERβ) are nuclear receptors which transduce estradiol (E2) response in many tissues including the mammary gland and breast cancers (BC). They activate or inhibit specific genes involved in cell cycle progression and cell survival through multiple enzyme activities leading to malignant transformation. Hormone therapy (antiestrogens (AEs) and aromatase inhibitors (AIs) have been widely used to block the mitogenic action of E2 in patients with ER-positive BC. ERs act in concert with numerous other proteins outside and inside the nucleus where co-activators such as histone modifying enzymes help reaching optimum gene activation. Moreover, E2-mediated gene regulation can occur through ERs located at the plasma membrane or G protein-coupled estrogen receptor (GPER), triggering protein kinase signaling cascades. Classical AEs as well as AIs are inefficient to block the cascades of events emanating from the membrane and from E2 binding to GPER, leading patients to escape anti-hormone treatments and hormone therapy resistance. Many pathways are involved in resistance, mostly resulting from over-expression of growth factor membrane receptors, in particular the HER2/ErbB2 which can be inhibited by specific antibodies or tyrosine kinases inhibitors. Together with the Hsp90 molecular chaperone machinery, a complex interplay between ERs, co-activators, co-repressors and growth factor-activated membrane pathways represents potent targets which warrant to be manipulated alone and in combination to designing novel therapies. The discovery of new potential targets arising from micro array studies gives the opportunity to activate or inhibit different new ER-modulating effectors for innovative therapeutic interventions." @default.
• W1997042214 created "2016-06-24" @default.
• W1997042214 creator A5047564616 @default.
• W1997042214 date "2012-10-01" @default.
• W1997042214 modified "2023-09-26" @default.
• W1997042214 title "Estradiol receptors in breast cancer cells: Associated co-factors as targets for new therapeutic approaches" @default.
• W1997042214 cites W1453600927 @default.
• W1997042214 cites W1491255630 @default.
• W1997042214 cites W1518308640 @default.
• W1997042214 cites W1529944274 @default.
• W1997042214 cites W1550188105 @default.
• W1997042214 cites W1590835357 @default.
• W1997042214 cites W1662062786 @default.
• W1997042214 cites W1718435705 @default.
• W1997042214 cites W1918073772 @default.
• W1997042214 cites W1932574503 @default.
• W1997042214 cites W1964423003 @default.
• W1997042214 cites W1964506243 @default.
• W1997042214 cites W1965080988 @default.
• W1997042214 cites W1966736624 @default.
• W1997042214 cites W1966878363 @default.
• W1997042214 cites W1967018540 @default.
• W1997042214 cites W1971621147 @default.
• W1997042214 cites W1971727708 @default.
• W1997042214 cites W1971821779 @default.
• W1997042214 cites W1974167857 @default.
• W1997042214 cites W1977737254 @default.
• W1997042214 cites W1978424403 @default.
• W1997042214 cites W1979662506 @default.
• W1997042214 cites W1980825754 @default.
• W1997042214 cites W1981467972 @default.
• W1997042214 cites W1981476886 @default.
• W1997042214 cites W1982403882 @default.
• W1997042214 cites W1983051513 @default.
• W1997042214 cites W1984621921 @default.
• W1997042214 cites W1985496287 @default.
• W1997042214 cites W1985976602 @default.
• W1997042214 cites W1986450208 @default.
• W1997042214 cites W1986986419 @default.
• W1997042214 cites W1989069744 @default.
• W1997042214 cites W1989778011 @default.
• W1997042214 cites W1990011854 @default.
• W1997042214 cites W1990529844 @default.
• W1997042214 cites W1997148771 @default.
• W1997042214 cites W1998162919 @default.
• W1997042214 cites W1999718274 @default.
• W1997042214 cites W2002262418 @default.
• W1997042214 cites W2002459343 @default.
• W1997042214 cites W2006363105 @default.
• W1997042214 cites W2007106751 @default.
• W1997042214 cites W2013809140 @default.
• W1997042214 cites W2013956549 @default.
• W1997042214 cites W2014584008 @default.
• W1997042214 cites W2014941193 @default.
• W1997042214 cites W2016168309 @default.
• W1997042214 cites W2018781502 @default.
• W1997042214 cites W2019502665 @default.
• W1997042214 cites W2020742237 @default.
• W1997042214 cites W2021851171 @default.
• W1997042214 cites W2022285476 @default.
• W1997042214 cites W2023307129 @default.
• W1997042214 cites W2023720844 @default.
• W1997042214 cites W2025412384 @default.
• W1997042214 cites W2025623674 @default.
• W1997042214 cites W2025935112 @default.
• W1997042214 cites W2027179411 @default.
• W1997042214 cites W2028236537 @default.
• W1997042214 cites W2029521041 @default.
• W1997042214 cites W2030837679 @default.
• W1997042214 cites W2031843272 @default.
• W1997042214 cites W2038208040 @default.
• W1997042214 cites W2041895008 @default.
• W1997042214 cites W2045792003 @default.
• W1997042214 cites W2047235158 @default.
• W1997042214 cites W2048539342 @default.
• W1997042214 cites W2051684862 @default.
• W1997042214 cites W2052253951 @default.
• W1997042214 cites W2052358607 @default.
• W1997042214 cites W2053580820 @default.
• W1997042214 cites W2054290614 @default.
• W1997042214 cites W2054576779 @default.
• W1997042214 cites W2056299617 @default.
• W1997042214 cites W2060756680 @default.
• W1997042214 cites W2061551473 @default.
• W1997042214 cites W2062244421 @default.
• W1997042214 cites W2062882032 @default.
• W1997042214 cites W2065282404 @default.
• W1997042214 cites W2066122607 @default.
• W1997042214 cites W2067233094 @default.
• W1997042214 cites W2068113812 @default.
• W1997042214 cites W2068552308 @default.
• W1997042214 cites W2070198605 @default.
• W1997042214 cites W2073353512 @default.
• W1997042214 cites W2074431026 @default.
• W1997042214 cites W2077279597 @default.
• W1997042214 cites W2078500792 @default.
• W1997042214 cites W2078537140 @default.
• W1997042214 cites W2079394315 @default.

• next