Matches in SemOpenAlex for { <https://semopenalex.org/work/W1997043642> ?p ?o ?g. }
- W1997043642 abstract "DNA produces a wide range of structures in addition to the canonical B-form of double-stranded DNA. Some of these structures are stabilized by Hoogsteen bonds. We developed an experimentally parameterized, coarse-grained model that incorporates such bonds. The model reproduces many of the microscopic features of double-stranded DNA and captures the experimental melting curves for a number of short DNA hairpins, even when the open state forms complicated secondary structures. We demonstrate the utility of the model by simulating the folding of a thrombin aptamer, which contains G-quartets, and strand invasion during triplex formation. Our results highlight the importance of including Hoogsteen bonding in coarse-grained models of DNA." @default.
- W1997043642 created "2016-06-24" @default.
- W1997043642 creator A5032928487 @default.
- W1997043642 creator A5072339132 @default.
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- W1997043642 date "2011-11-28" @default.
- W1997043642 modified "2023-09-24" @default.
- W1997043642 title "Moving beyond Watson–Crick models of coarse grained DNA dynamics" @default.
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- W1997043642 doi "https://doi.org/10.1063/1.3662137" @default.
- W1997043642 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3248023" @default.
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- W1997043642 hasPublicationYear "2011" @default.
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