FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1997044852> ?p ?o ?g. }

• W1997044852 endingPage "9521" @default.
• W1997044852 startingPage "9517" @default.
• W1997044852 abstract "Expression of the major heat shock and stress-induced protein, HSP70, is under complex regulatory control in human cells. In addition to being induced by physiological stress such as heat shock or transition metals, the HSP70 gene is induced by serum stimulation and immortalizing products of the adenovirus E1A 13S and polyoma large tumor antigen genes. Here we show that expression of the human HSP70 gene is tightly regulated during the cell cycle. Using selective mitotic detachment, a noninductive method to obtain synchronous populations of HeLa cells, we show that levels of HSP70 mRNA rapidly increase 10- to 15-fold upon entry into S phase and decline by late S and G2. A transient increase in HSP70 synthesis is detected during early S phase. The subcellular localization of HSP70 varies throughout the cell cycle; the protein is diffusely distributed in the nucleus and cytoplasm in G1, localized in the nucleus in S, and again diffusely distributed in G2 cells. We suggest that the temporal pattern of HSP70 expression during S phase, the nuclear localization, and activation by trans-acting immortalizing proteins indicate a role for HSP70 in the nucleus of replicating cells." @default.
• W1997044852 created "2016-06-24" @default.
• W1997044852 creator A5004866198 @default.
• W1997044852 creator A5090398521 @default.
• W1997044852 date "1986-12-01" @default.
• W1997044852 modified "2023-10-02" @default.
• W1997044852 title "Expression of human HSP70 during the synthetic phase of the cell cycle." @default.
• W1997044852 cites W1556340556 @default.
• W1997044852 cites W1606423922 @default.
• W1997044852 cites W1618691523 @default.
• W1997044852 cites W1760671874 @default.
• W1997044852 cites W1832547184 @default.
• W1997044852 cites W1895955548 @default.
• W1997044852 cites W1920231241 @default.
• W1997044852 cites W1952821629 @default.
• W1997044852 cites W1964892712 @default.
• W1997044852 cites W1970504454 @default.
• W1997044852 cites W1976245365 @default.
• W1997044852 cites W1983634837 @default.
• W1997044852 cites W1987703174 @default.
• W1997044852 cites W1995095999 @default.
• W1997044852 cites W2006558753 @default.
• W1997044852 cites W2018289835 @default.
• W1997044852 cites W2020611359 @default.
• W1997044852 cites W2021253208 @default.
• W1997044852 cites W2031684542 @default.
• W1997044852 cites W2032338163 @default.
• W1997044852 cites W2036719152 @default.
• W1997044852 cites W2037210916 @default.
• W1997044852 cites W2046425766 @default.
• W1997044852 cites W2050538329 @default.
• W1997044852 cites W2050905927 @default.
• W1997044852 cites W2053211604 @default.
• W1997044852 cites W2054073262 @default.
• W1997044852 cites W2055533988 @default.
• W1997044852 cites W2058795593 @default.
• W1997044852 cites W2059415989 @default.
• W1997044852 cites W2061236267 @default.
• W1997044852 cites W2062608816 @default.
• W1997044852 cites W2070341388 @default.
• W1997044852 cites W2070851087 @default.
• W1997044852 cites W2073386386 @default.
• W1997044852 cites W2075155315 @default.
• W1997044852 cites W2082205973 @default.
• W1997044852 cites W2084566007 @default.
• W1997044852 cites W2089654173 @default.
• W1997044852 cites W2091702992 @default.
• W1997044852 cites W2100837269 @default.
• W1997044852 cites W2111817213 @default.
• W1997044852 cites W2117079180 @default.
• W1997044852 cites W2156920104 @default.
• W1997044852 cites W2160395961 @default.
• W1997044852 cites W2161859305 @default.
• W1997044852 cites W2164515753 @default.
• W1997044852 cites W2164790171 @default.
• W1997044852 cites W2171065750 @default.
• W1997044852 cites W218971763 @default.
• W1997044852 cites W226104906 @default.
• W1997044852 cites W2292476398 @default.
• W1997044852 doi "https://doi.org/10.1073/pnas.83.24.9517" @default.
• W1997044852 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/387171" @default.
• W1997044852 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3540942" @default.
• W1997044852 hasPublicationYear "1986" @default.
• W1997044852 type Work @default.
• W1997044852 sameAs 1997044852 @default.
• W1997044852 citedByCount "290" @default.
• W1997044852 countsByYear W19970448522012 @default.
• W1997044852 countsByYear W19970448522013 @default.
• W1997044852 countsByYear W19970448522014 @default.
• W1997044852 countsByYear W19970448522015 @default.
• W1997044852 countsByYear W19970448522016 @default.
• W1997044852 countsByYear W19970448522018 @default.
• W1997044852 countsByYear W19970448522019 @default.
• W1997044852 countsByYear W19970448522020 @default.
• W1997044852 countsByYear W19970448522021 @default.
• W1997044852 crossrefType "journal-article" @default.
• W1997044852 hasAuthorship W1997044852A5004866198 @default.
• W1997044852 hasAuthorship W1997044852A5090398521 @default.
• W1997044852 hasBestOaLocation W19970448522 @default.
• W1997044852 hasConcept C104317684 @default.
• W1997044852 hasConcept C137984847 @default.
• W1997044852 hasConcept C1491633281 @default.
• W1997044852 hasConcept C150194340 @default.
• W1997044852 hasConcept C153911025 @default.
• W1997044852 hasConcept C190062978 @default.
• W1997044852 hasConcept C205260736 @default.
• W1997044852 hasConcept C2776879804 @default.
• W1997044852 hasConcept C2777366897 @default.
• W1997044852 hasConcept C2780114586 @default.
• W1997044852 hasConcept C2780723820 @default.
• W1997044852 hasConcept C29537977 @default.
• W1997044852 hasConcept C55493867 @default.
• W1997044852 hasConcept C68991219 @default.
• W1997044852 hasConcept C86803240 @default.
• W1997044852 hasConcept C93304396 @default.
• W1997044852 hasConcept C95444343 @default.
• W1997044852 hasConceptScore W1997044852C104317684 @default.
• W1997044852 hasConceptScore W1997044852C137984847 @default.

• next