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• W1997047507 abstract "In vitro studies on ionic requirements for melanophore-stimulating hormone (MSH) release were carried out on a variety of vertebrate species. Frog (Rana pipiens, Agalychnis dacnicolor), toad (Bufo marinus), lizard (Anolis carolinensis), mouse, and rat pituitaries release an MSH-like substance into the incubation medium. incubation of the separated pars distalis or pars intermedia of the frog or rat reveal that most MSH-like activity is confined to the intermediate lobe, suggesting that the hormone is MSH. Removal of the Ca2+ ion from the medium results in an almost total inhibition of MSH release from the pituitary of each of the species studied. Similarly, removal of the K+ ion reduces secretion to about half that of control values, except in the mouse and the toad (B. marinus), where such an effect could not be demonstrated. High (5×) K+ failed to increase the rate of MSH release in either normal or Ca2+-deficient media. Long-term (4–8 hr) incubation of frog or rat pituitaries in a Ca2+-deficient medium did not decrease the level of pituitary MSH over that of pituitaries incubated for similar lengths of time in normal media. Excess (10×) Ca2+ failed to stimulate MSH release from frog or rat pituitaries over that released into normal media. Ouabain reversibly blocked the release of MSH from frog (R. pipiens) and rat pituitaries. Ouabain failed to block MSH release from the mouse and the toad, B. marinus (the two species which were similarly unresponsive to the absence of K+ from the medium). MSH release from the frog was inhibited in a Li+-Ringer or an isotonic sucrose medium. These results suggest that MSH release from pars intermedia cells may be regulated by a Na+K+ pump (active transport) mechanism. Although Ca2+ is ultimately necessary for MSH release (in all species studied), its role may be secondary to that of an initial action of MSH release-inhibiting factors on cellular permeability to the K+ and/or Na+ ion. The experimental evidence presently suggests that some species may not possess an active transport system linked to the Ca2+ ion requirement for hormone release." @default.
• W1997047507 created "2016-06-24" @default.
• W1997047507 creator A5001337627 @default.
• W1997047507 creator A5071668584 @default.
• W1997047507 date "1972-08-01" @default.
• W1997047507 modified "2023-09-28" @default.
• W1997047507 title "Ionic requirements for melanophore-stimulating hormone (MSH) release" @default.
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• W1997047507 doi "https://doi.org/10.1016/0016-6480(72)90015-9" @default.
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• W1997047507 hasPublicationYear "1972" @default.
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