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• W1997062267 abstract "Aneurysmal subarachnoid hemorrhage (aSAH) is a devastating disease that affects approximately 30,000 people a year in the United States. Delayed cerebral ischemia (DCI) and cerebral vasospasm (CV) are common complications after aSAH. In addition, aSAH patients have a high risk of poor long-term outcomes. Endothelin-1 (ET-1), a potent vasoconstrictor, or its two types of receptors, ET receptor A (ET A ) and ET receptor B (ET B ), may play a role in the pathogenesis of DCI and CV. Genetic variations within the ET-1, ET A , or ET B genes may also account for variance observed in the outcomes of aSAH patients. The purpose of this study was to describe the distribution of the Lys198Asn polymorphism, a known functional SNP in the ET-1 gene, and tagging SNPs of the ET-1, ET A , and ET B genes in individuals recovering from aSAH. This study also investigated the relationships among the ET polymorphisms, DCI, and global functional outcomes measured at 3 and 6 months after aSAH. Participants included individuals aged 18–75 years with a diagnosis of aSAH. There was a trend found between the variant allele of an ET-1 SNP (rs6912834) and angiographic vasospasm. There were also associations found between two ET B SNPs (rs9574124 and rs3027111) and poor outcomes as measured by the Glasgow Outcome scale at 3 months. These findings support the role of ET-1 and ET B in recovery following aSAH." @default.
• W1997062267 created "2016-06-24" @default.
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• W1997062267 date "2012-09-19" @default.
• W1997062267 modified "2023-09-27" @default.
• W1997062267 title "Endothelin-1 and Endothelin Receptor Gene Variants and Their Association With Negative Outcomes Following Aneurysmal Subarachnoid Hemorrhage" @default.
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• W1997062267 doi "https://doi.org/10.1177/1099800412459674" @default.
• W1997062267 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3758781" @default.
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• W1997062267 hasPublicationYear "2012" @default.
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