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• W1997070105 abstract "SUMMARY The present study on rats and cats aimed to clarify the role played by hypoxia, hypercapnia and acidosis in spontaneous arrest of seizures. 1) In most experiments cortical pO2 declined during seizure activity, whereas pCO2 increased. Occasionally, however, reverse reactions occurred. Since the increase in cortical blood flow varied over a wide range, it could account for the fact that gas tension did not always change in the same direction or to the same degree during a seizure. Cessation of seizure activity was independent of the degree and direction of the changes in gas tension. 2) When seizures were arrested by experimentally produced hypoxia, cortical and spinal neurons always showed a distinct depolarization. When convulsive discharges were suppressed by artificial increase in PCO2 most units were concomitantly hyperpolarized. 3) When seizures ceased spontaneously, both cortical and spinal neurons showed a steep re- and hyperpolarization, independent of concomitant fluctuations in local gas tension. The findings lead to the conclusion that the degree of hypoxia and hypercapnia usually encountered during prolonged seizure activity does not reach the critical level sufficient to depress seizure activity. It must be assumed that spontaneous seizure termination is based, primarily, on neuronal processes. RESUME Cette étude se propose de préciser, chez les rats et les chats, le rôle de l'hypoxie, de l'hypercapnie et de l'acidose dans l'arrêt des crises spontanées. 1) Dans la majorité des expériences, Ia pO2 au niveau cortical diminue pendant la crise, tandis que la pCO2 augmente, quoique occasionnellement, on ait observé le contraire. La très grande variabilité de l'augmentation de la circulation sanguine cérébrale pouvait rendre compte du fait que pendant une crise, la tension des gaz ne changeait pas toujours dans le même sens ou dans les mêmes limites. L'arrêt de la crise était indépendant du degré et du type des modifications de la tension des gaz. 2) Lorsque les crises étaient arrêtées à la suite d'une anoxie provoquée expérimentalement, on a toujours observé une dépolarisation des neurones corticaux spinaux. Lorsque les décharges convulsives étaient supprimées par une augmentation artificielle de la pCO2, la majorité des neurones était parallèlement hyperpolarisée. 3) Lorsque les crises s'arrêtaient spontanément, les neurones du cortex et de la moelle montraient une rapide repolarisation et ensuite une hyperpolarisation indépendamment des fluctuations concomitantes de la tension des gaz. Ces données amènent à la conclusion que le degré d'hypoxie et d'hypercapnie qu'on observe habituellement pendant des crises prolongées n'atteint pas un niveau suffisant pour déprimer l'activité paroxystique. On doit en tirer la conclusion que l'arrêt spontané d'une crise est dûà des processus nerveux." @default.
• W1997070105 created "2016-06-24" @default.
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• W1997070105 creator A5012691532 @default.
• W1997070105 date "1972-09-01" @default.
• W1997070105 modified "2023-10-06" @default.
• W1997070105 title "Cerebral pO₂, pCO₂and pH: Changes During Convulsive Activity and their Significance for Spontaneous Arrest of Seizures" @default.
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• W1997070105 doi "https://doi.org/10.1111/j.1528-1157.1972.tb04403.x" @default.
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