FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1997078049> ?p ?o ?g. }

• W1997078049 endingPage "e111783" @default.
• W1997078049 startingPage "e111783" @default.
• W1997078049 abstract "Gliomas are mostly incurable secondary to their diffuse infiltrative nature. Thus, specific therapeutic targeting of invasive glioma cells is an attractive concept. As cells exit the tumor mass and infiltrate brain parenchyma, they closely interact with a changing micro-environmental landscape that sustains tumor cell invasion. In this study, we used a unique microarray profiling approach on a human glioma stem cell (GSC) xenograft model to explore gene expression changes in situ in Invading Glioma Cells (IGCs) compared to tumor core, as well as changes in host cells residing within the infiltrated microenvironment relative to the unaffected cortex. IGCs were found to have reduced expression of genes within the extracellular matrix compartment, and genes involved in cell adhesion, cell polarity and epithelial to mesenchymal transition (EMT) processes. The infiltrated microenvironment showed activation of wound repair and tissue remodeling networks. We confirmed by protein analysis the downregulation of EMT and polarity related genes such as CD44 and PARD3 in IGCs, and EFNB3, a tissue-remodeling agent enriched at the infiltrated microenvironment. OLIG2, a proliferation regulator and glioma progenitor cell marker upregulated in IGCs was found to function in enhancing migration and stemness of GSCs. Overall, our results unveiled a more comprehensive picture of the complex and dynamic cell autonomous and tumor-host interactive pathways of glioma invasion than has been previously demonstrated. This suggests targeting of multiple pathways at the junction of invading tumor and microenvironment as a viable option for glioma therapy." @default.
• W1997078049 created "2016-06-24" @default.
• W1997078049 creator A5010437305 @default.
• W1997078049 creator A5037673637 @default.
• W1997078049 creator A5043472876 @default.
• W1997078049 creator A5044640876 @default.
• W1997078049 creator A5045925835 @default.
• W1997078049 creator A5048256018 @default.
• W1997078049 creator A5055902091 @default.
• W1997078049 creator A5056721103 @default.
• W1997078049 creator A5062516537 @default.
• W1997078049 creator A5077523305 @default.
• W1997078049 creator A5079533477 @default.
• W1997078049 creator A5081985656 @default.
• W1997078049 creator A5087403626 @default.
• W1997078049 creator A5088565485 @default.
• W1997078049 creator A5089157846 @default.
• W1997078049 date "2014-11-03" @default.
• W1997078049 modified "2023-09-26" @default.
• W1997078049 title "Identification of Molecular Pathways Facilitating Glioma Cell Invasion In Situ" @default.
• W1997078049 cites W1573931073 @default.
• W1997078049 cites W1583052686 @default.
• W1997078049 cites W1964292350 @default.
• W1997078049 cites W1968328642 @default.
• W1997078049 cites W1971343062 @default.
• W1997078049 cites W1981142797 @default.
• W1997078049 cites W1981290819 @default.
• W1997078049 cites W1984839982 @default.
• W1997078049 cites W1992514491 @default.
• W1997078049 cites W1992638651 @default.
• W1997078049 cites W1993772187 @default.
• W1997078049 cites W1996123970 @default.
• W1997078049 cites W2002083668 @default.
• W1997078049 cites W2009663080 @default.
• W1997078049 cites W2014691022 @default.
• W1997078049 cites W2016708365 @default.
• W1997078049 cites W2018671779 @default.
• W1997078049 cites W2024384041 @default.
• W1997078049 cites W2026541878 @default.
• W1997078049 cites W2036406012 @default.
• W1997078049 cites W2038712067 @default.
• W1997078049 cites W2040458067 @default.
• W1997078049 cites W2040574920 @default.
• W1997078049 cites W2045942411 @default.
• W1997078049 cites W2050110645 @default.
• W1997078049 cites W2054948499 @default.
• W1997078049 cites W2057414874 @default.
• W1997078049 cites W2058374433 @default.
• W1997078049 cites W2062307771 @default.
• W1997078049 cites W2065891506 @default.
• W1997078049 cites W2071329523 @default.
• W1997078049 cites W2077177292 @default.
• W1997078049 cites W2080697543 @default.
• W1997078049 cites W2081314633 @default.
• W1997078049 cites W2089910171 @default.
• W1997078049 cites W2093217449 @default.
• W1997078049 cites W2099032267 @default.
• W1997078049 cites W2109199436 @default.
• W1997078049 cites W2109387315 @default.
• W1997078049 cites W2109531556 @default.
• W1997078049 cites W2113942802 @default.
• W1997078049 cites W2116039248 @default.
• W1997078049 cites W2123434257 @default.
• W1997078049 cites W2126611497 @default.
• W1997078049 cites W2127981279 @default.
• W1997078049 cites W2155388222 @default.
• W1997078049 cites W2155989003 @default.
• W1997078049 cites W2161289668 @default.
• W1997078049 cites W2162900557 @default.
• W1997078049 cites W39801448 @default.
• W1997078049 doi "https://doi.org/10.1371/journal.pone.0111783" @default.
• W1997078049 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4218815" @default.
• W1997078049 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25365423" @default.
• W1997078049 hasPublicationYear "2014" @default.
• W1997078049 type Work @default.
• W1997078049 sameAs 1997078049 @default.
• W1997078049 citedByCount "37" @default.
• W1997078049 countsByYear W19970780492015 @default.
• W1997078049 countsByYear W19970780492016 @default.
• W1997078049 countsByYear W19970780492017 @default.
• W1997078049 countsByYear W19970780492018 @default.
• W1997078049 countsByYear W19970780492019 @default.
• W1997078049 countsByYear W19970780492020 @default.
• W1997078049 countsByYear W19970780492021 @default.
• W1997078049 crossrefType "journal-article" @default.
• W1997078049 hasAuthorship W1997078049A5010437305 @default.
• W1997078049 hasAuthorship W1997078049A5037673637 @default.
• W1997078049 hasAuthorship W1997078049A5043472876 @default.
• W1997078049 hasAuthorship W1997078049A5044640876 @default.
• W1997078049 hasAuthorship W1997078049A5045925835 @default.
• W1997078049 hasAuthorship W1997078049A5048256018 @default.
• W1997078049 hasAuthorship W1997078049A5055902091 @default.
• W1997078049 hasAuthorship W1997078049A5056721103 @default.
• W1997078049 hasAuthorship W1997078049A5062516537 @default.
• W1997078049 hasAuthorship W1997078049A5077523305 @default.
• W1997078049 hasAuthorship W1997078049A5079533477 @default.
• W1997078049 hasAuthorship W1997078049A5081985656 @default.
• W1997078049 hasAuthorship W1997078049A5087403626 @default.

• next