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- W1997079253 abstract "A simple and sensitive HPLC method for the determination of gatifloxacin concentrations in human serum and urine was developed and validated. Serum proteins were removed by ultrafiltration through a filtering device after adding a displacing agent. Urine samples were diluted with mobile phase prior to injection. Separation was achieved with a C18 reverse-phase column and gatifloxacin concentrations were determined using ultraviolet detection. The quantitation limits of the assay were 100 ng/ml in serum and 1.0 microg/ml in urine. The assay method was successfully applied to a pharmacokinetic study of gatifloxacin in healthy volunteers." @default.
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- W1997079253 date "2003-12-05" @default.
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- W1997079253 title "Determination of gatifloxacin in human serum and urine by high-performance liquid chromatography with ultraviolet detection" @default.
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- W1997079253 doi "https://doi.org/10.1016/j.jchromb.2003.09.020" @default.
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