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• W1997079498 startingPage "143" @default.
• W1997079498 abstract "Inorganic arsenic is a known human carcinogen, yet its mechanism of action remains poorly understood. Epidemiological data suggest that arsenic exposure interacts with UV radiation exposure to increase the risk of skin cancer. Studies have suggested that arsenic is able to impair DNA repair enzymes and alter the repair of UV‐induced DNA damage. Here we have tested the hypothesis that arsenite [As(III)] and UV interact synergistically to enhance mutagenesis. TK6 human lymphoblastoid cells that are functionally heterozygous at the thymidine kinase (TK) locus were pre‐exposed to As(III) alone and in combination with UV. Our data suggest that As(III) is mutagenic only at high doses at the TK locus. As(III) enhanced UV mutagenesis in a more than additive fashion. To investigate the mechanism underlying this synergy we assessed the removal of UV‐induced dimers in TK6 cells using the T4 endonuclease‐incorporated Comet assay. Pre‐treatment with As(III) specifically inhibited the repair of UV‐induced pyrimidine dimer‐related DNA damage. Taken together, these data suggest that pre‐treatment of human cells with arsenic impairs the nucleotide excision repair pathway and leads to enhanced UV mutagenesis." @default.
• W1997079498 created "2016-06-24" @default.
• W1997079498 creator A5026551753 @default.
• W1997079498 date "2004-03-01" @default.
• W1997079498 modified "2023-10-18" @default.
• W1997079498 title "Low dose exposure to sodium arsenite synergistically interacts with UV radiation to induce mutations and alter DNA repair in human cells" @default.
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• W1997079498 doi "https://doi.org/10.1093/mutage/geh010" @default.
• W1997079498 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/14981161" @default.
• W1997079498 hasPublicationYear "2004" @default.
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