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- W1997083548 abstract "This review focuses on putative targets, including costimulatory and additional pathways involving T regulatory cells, that may be critical for modifying allergic responses.Multiple costimulatory signals including CD28/CTLA4: CD80/CD86, ICOS: ICOSL, OX40:OX40L and PD-1: PD-L1/PD-L2 have been identified and implicated in the regulation of immune disorders. Recent studies indicate that T regulatory cells may also suppress T cell costimulation by the secretion of TGF-beta and IL-10, suggesting an important role of T regulatory cells in the regulation of allergic disorders.Immune-mediated disorders, including allergic diseases, have been increasing in prevalence. Unravelling these immune pathways may suggest new targets for immunomodulation." @default.
- W1997083548 created "2016-06-24" @default.
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- W1997083548 date "2006-12-01" @default.
- W1997083548 modified "2023-10-15" @default.
- W1997083548 title "Immunomodulation of allergic responses by targeting costimulatory molecules" @default.
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- W1997083548 doi "https://doi.org/10.1097/01.all.0000246624.79988.5b" @default.
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