Matches in SemOpenAlex for { <https://semopenalex.org/work/W1997084080> ?p ?o ?g. }
Showing items 1 to 90 of
90
with 100 items per page.
- W1997084080 endingPage "1034" @default.
- W1997084080 startingPage "1029" @default.
- W1997084080 abstract "Under anaerobic conditions, various halogenated compounds, when metabolized by cytochrome P-450, form complexes which are spectrally detectable. Previous studies have shown that halothane forms such a complex with cytochrome P-450, and the result is a strong absorption at 470 nm. Stabilization of this proposed intermediate carbanion complex has never been demonstrated in a biological system. Data are presented which show that several organic solvents (C5-C7N-alkanes) will stabilize the complex formed between halothane and cytochrome P-450. Stabilization allowed the decay of the complex to be studied, and it is demonstrated that the product of decay was chlorodifluoroethylene, which substantiates the hypothesis that the complex is a two electron-reduced carbanion. Carbon tetrachloride and benzyl bromide, which also produce spectrally visible intermediate complexes, were not stabilized by this treatment. Stabilization of the halothane complex in a biological system may facilitate studies to identify precisely the halothane-cytochrome P-450 complex and to clarify the mechanisms of halothane reduction by cytochrome P-450." @default.
- W1997084080 created "2016-06-24" @default.
- W1997084080 creator A5008614497 @default.
- W1997084080 creator A5015692099 @default.
- W1997084080 creator A5067558640 @default.
- W1997084080 date "1987-04-01" @default.
- W1997084080 modified "2023-09-27" @default.
- W1997084080 title "Stabilization of the reduced halocarbon-cytochrome P-450 complex of halothane by N-alkanes" @default.
- W1997084080 cites W1531349046 @default.
- W1997084080 cites W1574339292 @default.
- W1997084080 cites W1806194750 @default.
- W1997084080 cites W1903873355 @default.
- W1997084080 cites W1951469402 @default.
- W1997084080 cites W2002129419 @default.
- W1997084080 cites W2007928674 @default.
- W1997084080 cites W2009356354 @default.
- W1997084080 cites W2011471278 @default.
- W1997084080 cites W2012496674 @default.
- W1997084080 cites W2025191715 @default.
- W1997084080 cites W2035540301 @default.
- W1997084080 cites W2041110178 @default.
- W1997084080 cites W2042670041 @default.
- W1997084080 cites W2053257748 @default.
- W1997084080 cites W2065082414 @default.
- W1997084080 cites W2079536532 @default.
- W1997084080 cites W2095788547 @default.
- W1997084080 doi "https://doi.org/10.1016/0006-2952(87)90410-2" @default.
- W1997084080 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3566799" @default.
- W1997084080 hasPublicationYear "1987" @default.
- W1997084080 type Work @default.
- W1997084080 sameAs 1997084080 @default.
- W1997084080 citedByCount "4" @default.
- W1997084080 crossrefType "journal-article" @default.
- W1997084080 hasAuthorship W1997084080A5008614497 @default.
- W1997084080 hasAuthorship W1997084080A5015692099 @default.
- W1997084080 hasAuthorship W1997084080A5067558640 @default.
- W1997084080 hasConcept C155647269 @default.
- W1997084080 hasConcept C178790620 @default.
- W1997084080 hasConcept C181199279 @default.
- W1997084080 hasConcept C185592680 @default.
- W1997084080 hasConcept C190283241 @default.
- W1997084080 hasConcept C2776300020 @default.
- W1997084080 hasConcept C2776932660 @default.
- W1997084080 hasConcept C2777359374 @default.
- W1997084080 hasConcept C2778870691 @default.
- W1997084080 hasConcept C2780055204 @default.
- W1997084080 hasConcept C2780768313 @default.
- W1997084080 hasConcept C29311851 @default.
- W1997084080 hasConcept C55493867 @default.
- W1997084080 hasConcept C71240020 @default.
- W1997084080 hasConcept C75473681 @default.
- W1997084080 hasConcept C82894169 @default.
- W1997084080 hasConceptScore W1997084080C155647269 @default.
- W1997084080 hasConceptScore W1997084080C178790620 @default.
- W1997084080 hasConceptScore W1997084080C181199279 @default.
- W1997084080 hasConceptScore W1997084080C185592680 @default.
- W1997084080 hasConceptScore W1997084080C190283241 @default.
- W1997084080 hasConceptScore W1997084080C2776300020 @default.
- W1997084080 hasConceptScore W1997084080C2776932660 @default.
- W1997084080 hasConceptScore W1997084080C2777359374 @default.
- W1997084080 hasConceptScore W1997084080C2778870691 @default.
- W1997084080 hasConceptScore W1997084080C2780055204 @default.
- W1997084080 hasConceptScore W1997084080C2780768313 @default.
- W1997084080 hasConceptScore W1997084080C29311851 @default.
- W1997084080 hasConceptScore W1997084080C55493867 @default.
- W1997084080 hasConceptScore W1997084080C71240020 @default.
- W1997084080 hasConceptScore W1997084080C75473681 @default.
- W1997084080 hasConceptScore W1997084080C82894169 @default.
- W1997084080 hasIssue "7" @default.
- W1997084080 hasLocation W19970840801 @default.
- W1997084080 hasLocation W19970840802 @default.
- W1997084080 hasOpenAccess W1997084080 @default.
- W1997084080 hasPrimaryLocation W19970840801 @default.
- W1997084080 hasRelatedWork W1970112881 @default.
- W1997084080 hasRelatedWork W1974438630 @default.
- W1997084080 hasRelatedWork W1976796557 @default.
- W1997084080 hasRelatedWork W1997084080 @default.
- W1997084080 hasRelatedWork W2055463858 @default.
- W1997084080 hasRelatedWork W2075927413 @default.
- W1997084080 hasRelatedWork W2085557007 @default.
- W1997084080 hasRelatedWork W2087439365 @default.
- W1997084080 hasRelatedWork W2343737789 @default.
- W1997084080 hasRelatedWork W2952508841 @default.
- W1997084080 hasVolume "36" @default.
- W1997084080 isParatext "false" @default.
- W1997084080 isRetracted "false" @default.
- W1997084080 magId "1997084080" @default.
- W1997084080 workType "article" @default.