Matches in SemOpenAlex for { <https://semopenalex.org/work/W1997092079> ?p ?o ?g. }
Showing items 1 to 96 of
96
with 100 items per page.
- W1997092079 abstract "Background: Inflammatory breast cancer (IBC) is an aggressive form of locally advanced breast cancer (LABC) with poor response to treatment or metastasis in one-third of patients at presentation. The aggressive behavior of IBC was attributed to the cancer stem cell (CSC) component in these tumors. We assessed the correlation between CSC markers in IBC, LABC and the aggressive behavior of these tumors compared to invasive duct carcinoma (IDC-NOS). Methods: CD44, CD90, CD133, nestin, SOX2 and OCT4 RNA and proteins expression were assessed in 30 cases of IDC-NOS, IBC and LABC (each) using quantitative real time PCR (qPCR) and immunohistochemistry (IHC). Markers expression was correlated to patients9 characteristics, response to treatment, 4 years- overall and progression free survival (OS& PFS) . Results: The expression levels in IBC and LABC was as follows: (CD44; 70%& 26.3%, p=0.003), (CD90; 49.2%& 28.1%, p=0.06), (CD133; 66.7%& 26.3%, p=0.006), (OCT4; 70%& 26.6%, p=0.004), (SOX2: 63.3%& 30%, p=0.02) and (Nestin; 53.3%& 31%, p=0.08). The difference in the expression levels of all studied markers between IDC-NOS and the other two groups was statistically significant (p.value: Conclusions: The aggressive phenotype of IBC and LABC could be attributed, at least partially, to the presence of CSC populations in these tumors. Therefore, CSC markers represent Interesting candidates for targeted therapy for this resistant type of breast tumors. Citation Format: Abdel-Rahman N. Zekri, Abeer Bahnassy, Ahmed E. El-Bastawisy, Hanan R. Nassar, Neveen M. Elhady, John Effat. Stem cells like phenotype of inflammatory breast cancer and locally advanced breast cancer: increased expression of sox2 and oct3/4 contributes to poor response to treatment and reduced survival rates. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 4735. doi:10.1158/1538-7445.AM2014-4735" @default.
- W1997092079 created "2016-06-24" @default.
- W1997092079 creator A5013193085 @default.
- W1997092079 creator A5016320447 @default.
- W1997092079 creator A5020246742 @default.
- W1997092079 creator A5020718864 @default.
- W1997092079 creator A5038538552 @default.
- W1997092079 creator A5054664767 @default.
- W1997092079 date "2014-09-30" @default.
- W1997092079 modified "2023-09-25" @default.
- W1997092079 title "Abstract 4735: Stem cells like phenotype of inflammatory breast cancer and locally advanced breast cancer: increased expression of sox2 and oct3/4 contributes to poor response to treatment and reduced survival rates" @default.
- W1997092079 doi "https://doi.org/10.1158/1538-7445.am2014-4735" @default.
- W1997092079 hasPublicationYear "2014" @default.
- W1997092079 type Work @default.
- W1997092079 sameAs 1997092079 @default.
- W1997092079 citedByCount "0" @default.
- W1997092079 crossrefType "proceedings-article" @default.
- W1997092079 hasAuthorship W1997092079A5013193085 @default.
- W1997092079 hasAuthorship W1997092079A5016320447 @default.
- W1997092079 hasAuthorship W1997092079A5020246742 @default.
- W1997092079 hasAuthorship W1997092079A5020718864 @default.
- W1997092079 hasAuthorship W1997092079A5038538552 @default.
- W1997092079 hasAuthorship W1997092079A5054664767 @default.
- W1997092079 hasConcept C104317684 @default.
- W1997092079 hasConcept C116716535 @default.
- W1997092079 hasConcept C121608353 @default.
- W1997092079 hasConcept C126322002 @default.
- W1997092079 hasConcept C136834591 @default.
- W1997092079 hasConcept C142724271 @default.
- W1997092079 hasConcept C143998085 @default.
- W1997092079 hasConcept C1491633281 @default.
- W1997092079 hasConcept C204232928 @default.
- W1997092079 hasConcept C2777738006 @default.
- W1997092079 hasConcept C2777933648 @default.
- W1997092079 hasConcept C2779013556 @default.
- W1997092079 hasConcept C2780839634 @default.
- W1997092079 hasConcept C2780932548 @default.
- W1997092079 hasConcept C28328180 @default.
- W1997092079 hasConcept C502942594 @default.
- W1997092079 hasConcept C530470458 @default.
- W1997092079 hasConcept C54355233 @default.
- W1997092079 hasConcept C55427017 @default.
- W1997092079 hasConcept C55493867 @default.
- W1997092079 hasConcept C71924100 @default.
- W1997092079 hasConcept C86339819 @default.
- W1997092079 hasConcept C86803240 @default.
- W1997092079 hasConceptScore W1997092079C104317684 @default.
- W1997092079 hasConceptScore W1997092079C116716535 @default.
- W1997092079 hasConceptScore W1997092079C121608353 @default.
- W1997092079 hasConceptScore W1997092079C126322002 @default.
- W1997092079 hasConceptScore W1997092079C136834591 @default.
- W1997092079 hasConceptScore W1997092079C142724271 @default.
- W1997092079 hasConceptScore W1997092079C143998085 @default.
- W1997092079 hasConceptScore W1997092079C1491633281 @default.
- W1997092079 hasConceptScore W1997092079C204232928 @default.
- W1997092079 hasConceptScore W1997092079C2777738006 @default.
- W1997092079 hasConceptScore W1997092079C2777933648 @default.
- W1997092079 hasConceptScore W1997092079C2779013556 @default.
- W1997092079 hasConceptScore W1997092079C2780839634 @default.
- W1997092079 hasConceptScore W1997092079C2780932548 @default.
- W1997092079 hasConceptScore W1997092079C28328180 @default.
- W1997092079 hasConceptScore W1997092079C502942594 @default.
- W1997092079 hasConceptScore W1997092079C530470458 @default.
- W1997092079 hasConceptScore W1997092079C54355233 @default.
- W1997092079 hasConceptScore W1997092079C55427017 @default.
- W1997092079 hasConceptScore W1997092079C55493867 @default.
- W1997092079 hasConceptScore W1997092079C71924100 @default.
- W1997092079 hasConceptScore W1997092079C86339819 @default.
- W1997092079 hasConceptScore W1997092079C86803240 @default.
- W1997092079 hasLocation W19970920791 @default.
- W1997092079 hasOpenAccess W1997092079 @default.
- W1997092079 hasPrimaryLocation W19970920791 @default.
- W1997092079 hasRelatedWork W1555773983 @default.
- W1997092079 hasRelatedWork W1978483919 @default.
- W1997092079 hasRelatedWork W1982259610 @default.
- W1997092079 hasRelatedWork W1988883987 @default.
- W1997092079 hasRelatedWork W2017980240 @default.
- W1997092079 hasRelatedWork W2022922468 @default.
- W1997092079 hasRelatedWork W2036152798 @default.
- W1997092079 hasRelatedWork W2044207515 @default.
- W1997092079 hasRelatedWork W2048947140 @default.
- W1997092079 hasRelatedWork W2073349529 @default.
- W1997092079 hasRelatedWork W2083984673 @default.
- W1997092079 hasRelatedWork W2317623922 @default.
- W1997092079 hasRelatedWork W2790356395 @default.
- W1997092079 hasRelatedWork W2801132258 @default.
- W1997092079 hasRelatedWork W2807149660 @default.
- W1997092079 hasRelatedWork W2905574941 @default.
- W1997092079 hasRelatedWork W2911222552 @default.
- W1997092079 hasRelatedWork W2972550474 @default.
- W1997092079 hasRelatedWork W3012114091 @default.
- W1997092079 hasRelatedWork W3045798118 @default.
- W1997092079 isParatext "false" @default.
- W1997092079 isRetracted "false" @default.
- W1997092079 magId "1997092079" @default.
- W1997092079 workType "article" @default.