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• W1997095142 abstract "Objective: Glutamine (Gln)–supplemented total parenteral nutrition (TPN) improves clinical outcome after planned surgery, but the benefits of Gln-TPN for critically ill (intensive care unit; ICU) patients are still debated. Design: Prospective, double-blind, controlled, randomized trial. Setting: ICUs in 16 hospitals in France. Patients: One-hundred fourteen ICU patients admitted for multiple trauma (38), complicated surgery (65), or pancreatitis (11). Interventions: Patients were randomized to receive isocaloric isonitrogenous TPN via a central venous catheter providing 37.5 kcal and 1.5 g amino acids·kg−1·day−1 supplemented with either L-alanyl-L-glutamine dipeptide (0.5 g·kg−1·day−1; Ala-Gln group, n = 58) or L-alanine + L-proline (control group, n = 56) over at least 5 days. Measurements and Main Results: Complicated clinical outcome was defined a priori by the occurrence of infectious complications (according to the criteria of the Centers for Disease Control and Prevention), wound complication, or death. The two groups were compared by chi-square test on an intention-to-treat basis. The two groups did not differ at inclusion for type and severity of injury (mean simplified acute physiology score II, 30 vs. 30.5; mean injury severity score, 44.9 vs. 42.3). Similar volumes of TPN were administered in both groups. Ala-Gln-supplemented TPN was associated with a lower incidence of complicated outcome (41% vs. 61%; p < .05), which was mainly due to a reduced infection rate per patient (mean, 0.45 vs. 0.71; p < .05) and incidence of pneumonia (10 vs. 19; p < .05). Early death rate during treatment and 6-month survival were not different. Hyperglycemia was less frequent (20 vs. 30 patients; p < .05) and there were fewer insulin-requiring patients (14 vs. 22; p < .05) in the Ala-Gln group. Conclusions: TPN supplemented with Ala-Gln dipeptide in ICU patients is associated with a reduced rate of infectious complications and better metabolic tolerance." @default.
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• W1997095142 date "2006-03-01" @default.
• W1997095142 modified "2023-10-16" @default.
• W1997095142 title "L-alanyl-L-glutamine dipeptide–supplemented total parenteral nutrition reduces infectious complications and glucose intolerance in critically ill patients: The French controlled, randomized, double-blind, multicenter study*" @default.
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• W1997095142 cites W1980717583 @default.
• W1997095142 cites W2009649501 @default.
• W1997095142 cites W2011494742 @default.
• W1997095142 cites W2013270170 @default.
• W1997095142 cites W2027495250 @default.
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• W1997095142 cites W2042034626 @default.
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• W1997095142 doi "https://doi.org/10.1097/01.ccm.0000201004.30750.d1" @default.
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