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- W1997097788 abstract "In 1962 Eisinger and coworkers first postulated an interaction of Cr(III) with the phosphate groups of native DNA (J. Eisinger et al., J. Chem. Phys. 36, 1721, 1962). As an indicator for the strength of the molecular interaction between Cr(III) and the phosphate groups in DNA, Eisinger measured the proton relaxation time. Weser in 1968 showed a direct interaction between Mn(II) and Cu(II) and the phosphate groups of ATP by use of phosphorus magnetic resonance spectroscopy (U. Weser, Structure and Bonding 5, 41, 1968). With proton magnetic resonance spectroscopy he demonstrated an interaction of the N‐7 position in AMP and ATP with Cu(II). Similar results were obtained by Eichhorn and coworkers (G. L. Eichhorn et al., Adv. Chem. Series 100, 135, 1971). Furthermore, Eichhorn substituted the N‐7 of purine monophosphate nucleotides against carbon resulting in no interaction with copper ions. In our study we used 31‐P‐NMR spectroscopy to elucidate the molecular interaction of Cr(III) and Cr(VI) ions with CTP, GTP, GDP, ATP, ADP, dATP. We choose the interaction of Mg(II) and ATP as reference for a metal ion interaction with a phosphorus‐containing nucleotide. Only Cr(III) compounds showed concentration dependent interactions of the metal ion with the phosphate groups. These effects were characterized by differential downfield shifts and signal broadening for the alpha, beta‐ and gamma‐phosphate groups which could only be explained by interaction of Cr(III). The paramagnetic influence of Cr(III) alone would result in an homologous downfield shift and signal broadening for all three phosphate groups. In contrast, none of these interactions could be found with Cr(VI). In contrast, none of these interactions could be found with Cr(VI). These results are therefore consistent with the concept that only Cr(III) compounds ultimately interact with DNA." @default.
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- W1997097788 date "1989-06-01" @default.
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- W1997097788 title "Different molecular effects on nucleotides by interaction with cr(iii) and cr(vi): A31P‐NMR studyin vitro∗" @default.
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- W1997097788 doi "https://doi.org/10.1080/02772248909357444" @default.
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