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- W1997102492 abstract "Rats were made hyper-reactive by the placement of mechanical lesions in the septal area. Phenobarbital (20 mg/kg), pentobarbital (10 mg/kg), amobarbital (30 mg/kg), meprobamate (100 mg/kg), chlorpromazine (5 mg/kg), trifluoperazine (2.5 mg/kg) and chlordiazepoxide (20 mg/kg) were administered intraperitoneally to rats with septal lesions and the effects of these drugs on the reactivity of the rats were measured. The three barbiturates and meprobamate had no effect on the parameters measured. The doses of these drugs were sufficient to cause obvious ataxia in the animals. Chlorpromazine, trifluoperazine and chlordiazepoxide markedly inhibited the reactivity of the rats. The septal-lesioned rat preparation can be used to differentiate some psychotherapeutic agents from the general group of CNS depressants." @default.
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- W1997102492 title "Differentiation of classes of neurosedatives using rats with septal lesions" @default.
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- W1997102492 doi "https://doi.org/10.1016/0028-3908(66)90002-5" @default.
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