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- W1997103304 abstract "With the availability of increasingly potent acid-suppressing medications, questions continue to rise concerning the safety of these compounds in regards to carcinogenetic potential. In this review, we examine current concepts and procedures relating to genotoxicity, the potential for a chemical agent to interact with and alter the genomic information of the cell, and carcinogenesis. A description and discussion of commonly utilized techniques for the determination of (a) in vitro mutagenicity, (b) in vitro and in vivo DNA damage and repair, (c) in vitro and in vivo chromosomal damage and (d) chronically dosed animal tumorigenesis development is presented. Observations from these procedures as they have been applied to a review of the safety of acid-suppressing medications will be discussed. An evaluation of reports relating to potential genotoxic and carcinogenic hazards of therapeutically relevant acid-suppressing medications (cimetidine, ranitidine, omeprazole) is presented. Information related to the effect of prolonged administration of acid-suppressing medications, alterations of serum gastrin levels, and the potential for tumor promotion is discussed." @default.
- W1997103304 created "2016-06-24" @default.
- W1997103304 creator A5027183517 @default.
- W1997103304 creator A5030580928 @default.
- W1997103304 creator A5071154577 @default.
- W1997103304 date "1995-01-01" @default.
- W1997103304 modified "2023-09-28" @default.
- W1997103304 title "Genotoxicity, carcinogenicity and acid-suppressing medications" @default.
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- W1997103304 doi "https://doi.org/10.1016/0163-7258(95)98596-i" @default.
- W1997103304 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7644566" @default.
- W1997103304 hasPublicationYear "1995" @default.
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