Matches in SemOpenAlex for { <https://semopenalex.org/work/W1997103423> ?p ?o ?g. }
Showing items 1 to 73 of
73
with 100 items per page.
- W1997103423 abstract "The metabolites were identified by gas chromatography-mass spectrometry (GC-MS). When an equimolar mixture of roxatidine acetate hydrochloride and its deuterated compound, labeled with ten deuterium atoms in the piperidine ring, was incubated with the 9000 X g supernatant (S-9) fraction of either rat or dog liver homogenate, the oxygenated metabolites of the piperidine ring such as the 3-hydroxypiperidine derivative (M1) and the 2-oxopiperidine derivative (M2) were isolated from rats but M2 was not isolated from dogs. These results suggested that the species differences in the metabolism of the piperidine ring in vitro are similar to that in vivo. The deuterium isotope effect (H/D) was 1.34 for M1 and 1.47 for M2 in rats, while the value for M1 in dogs was 1.69. On the other hand, the formation of these oxidative metabolites was inhibited by carbon monoxide in incubations using hepatic microsomes, suggesting that the reaction was catalyzed by cytochromes P-450." @default.
- W1997103423 created "2016-06-24" @default.
- W1997103423 creator A5006399499 @default.
- W1997103423 creator A5043695093 @default.
- W1997103423 creator A5045495683 @default.
- W1997103423 creator A5089676982 @default.
- W1997103423 creator A5080201008 @default.
- W1997103423 date "1987-01-01" @default.
- W1997103423 modified "2023-09-24" @default.
- W1997103423 title "The metabolism of roxatidine acetate hydrochloride in rat and dog liver homogenates." @default.
- W1997103423 cites W1775749144 @default.
- W1997103423 cites W1951469402 @default.
- W1997103423 cites W2064690299 @default.
- W1997103423 cites W2095441596 @default.
- W1997103423 cites W2405663915 @default.
- W1997103423 cites W584026269 @default.
- W1997103423 cites W2410314011 @default.
- W1997103423 doi "https://doi.org/10.1248/bpb1978.10.229" @default.
- W1997103423 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2889823" @default.
- W1997103423 hasPublicationYear "1987" @default.
- W1997103423 type Work @default.
- W1997103423 sameAs 1997103423 @default.
- W1997103423 citedByCount "1" @default.
- W1997103423 countsByYear W19971034232015 @default.
- W1997103423 crossrefType "journal-article" @default.
- W1997103423 hasAuthorship W1997103423A5006399499 @default.
- W1997103423 hasAuthorship W1997103423A5043695093 @default.
- W1997103423 hasAuthorship W1997103423A5045495683 @default.
- W1997103423 hasAuthorship W1997103423A5080201008 @default.
- W1997103423 hasAuthorship W1997103423A5089676982 @default.
- W1997103423 hasBestOaLocation W19971034231 @default.
- W1997103423 hasConcept C150903083 @default.
- W1997103423 hasConcept C185592680 @default.
- W1997103423 hasConcept C202751555 @default.
- W1997103423 hasConcept C207001950 @default.
- W1997103423 hasConcept C2776460385 @default.
- W1997103423 hasConcept C2781462491 @default.
- W1997103423 hasConcept C43617362 @default.
- W1997103423 hasConcept C55493867 @default.
- W1997103423 hasConcept C62231903 @default.
- W1997103423 hasConcept C71240020 @default.
- W1997103423 hasConcept C86803240 @default.
- W1997103423 hasConcept C87644729 @default.
- W1997103423 hasConceptScore W1997103423C150903083 @default.
- W1997103423 hasConceptScore W1997103423C185592680 @default.
- W1997103423 hasConceptScore W1997103423C202751555 @default.
- W1997103423 hasConceptScore W1997103423C207001950 @default.
- W1997103423 hasConceptScore W1997103423C2776460385 @default.
- W1997103423 hasConceptScore W1997103423C2781462491 @default.
- W1997103423 hasConceptScore W1997103423C43617362 @default.
- W1997103423 hasConceptScore W1997103423C55493867 @default.
- W1997103423 hasConceptScore W1997103423C62231903 @default.
- W1997103423 hasConceptScore W1997103423C71240020 @default.
- W1997103423 hasConceptScore W1997103423C86803240 @default.
- W1997103423 hasConceptScore W1997103423C87644729 @default.
- W1997103423 hasLocation W19971034231 @default.
- W1997103423 hasLocation W19971034232 @default.
- W1997103423 hasOpenAccess W1997103423 @default.
- W1997103423 hasPrimaryLocation W19971034231 @default.
- W1997103423 hasRelatedWork W1781769434 @default.
- W1997103423 hasRelatedWork W1995363240 @default.
- W1997103423 hasRelatedWork W2008995722 @default.
- W1997103423 hasRelatedWork W2019780857 @default.
- W1997103423 hasRelatedWork W2033627181 @default.
- W1997103423 hasRelatedWork W2035747340 @default.
- W1997103423 hasRelatedWork W2103681475 @default.
- W1997103423 hasRelatedWork W2371841285 @default.
- W1997103423 hasRelatedWork W2379581798 @default.
- W1997103423 hasRelatedWork W2395025359 @default.
- W1997103423 isParatext "false" @default.
- W1997103423 isRetracted "false" @default.
- W1997103423 magId "1997103423" @default.
- W1997103423 workType "article" @default.