FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1997103498> ?p ?o ?g. }

• W1997103498 endingPage "1594" @default.
• W1997103498 startingPage "1587" @default.
• W1997103498 abstract "Intervertebral disc (IVD) cells within the annulus fibrosus (AF) and nucleus pulposus (NP) maintain distinct functional extracellular matrices and operate within a potentially noxious and stressful environment. How disc cells respond to stress and whether stress is responsible for triggering degeneration is unknown. Disc cell proliferation and cluster formation are most marked in degenerate IVDs, possibly indicating attempts at matrix repair. In other tissues, stress proteins increase rapidly after stress protecting cell function and, although implicated in degeneration of articular cartilage, have received little attention in degenerative IVD pathologies. We have compared the distribution of stress protein immunolocalization in pathological and control IVDs. Disc tissues were obtained at surgery from 43 patients with degenerative disc disease (DDD) and herniation, and 12 controls at postmortem. Tissues were immunostained with a polyclonal antibody for heat shock factor 1 (HSF-1) and monoclonal antibodies for the heat shock proteins, Hsp27 and Hsp72, using an indirect immunoperoxidase method. Positively stained cells were expressed as a percentage of the total. Cell cluster formation was also assessed. The proportion of cells in clusters was similar in the AF (both 2%) and NP (8 and 9%) of control and DDD samples, whereas in herniated tissues this was increased (AF 12%, NP 14%). Stress antigen staining tended to be more frequent in clustered rather than in single/doublet cells, and this was significant (P < 0.005) in both the AF and NP of herniated discs. Clustered cells, which are most common in herniated discs, may be mounting a protective response to abnormal environmental factors associated with disc degeneration. A better understanding of the stress response in IVD cells may allow its utilization in disc cell therapies." @default.
• W1997103498 created "2016-06-24" @default.
• W1997103498 creator A5013277398 @default.
• W1997103498 creator A5040066030 @default.
• W1997103498 creator A5043026845 @default.
• W1997103498 creator A5056951156 @default.
• W1997103498 date "2009-06-11" @default.
• W1997103498 modified "2023-10-17" @default.
• W1997103498 title "Disc cell clusters in pathological human intervertebral discs are associated with increased stress protein immunostaining" @default.
• W1997103498 cites W1901873593 @default.
• W1997103498 cites W1964344469 @default.
• W1997103498 cites W1967138582 @default.
• W1997103498 cites W1970108896 @default.
• W1997103498 cites W1994654873 @default.
• W1997103498 cites W2005763581 @default.
• W1997103498 cites W2013017205 @default.
• W1997103498 cites W2021449823 @default.
• W1997103498 cites W2021829189 @default.
• W1997103498 cites W2024585159 @default.
• W1997103498 cites W2028000988 @default.
• W1997103498 cites W2031763978 @default.
• W1997103498 cites W2032897684 @default.
• W1997103498 cites W2033580819 @default.
• W1997103498 cites W2042929078 @default.
• W1997103498 cites W2043433277 @default.
• W1997103498 cites W2051083202 @default.
• W1997103498 cites W2060861339 @default.
• W1997103498 cites W2065246790 @default.
• W1997103498 cites W2067682644 @default.
• W1997103498 cites W2076159058 @default.
• W1997103498 cites W2080270214 @default.
• W1997103498 cites W2100690669 @default.
• W1997103498 cites W2103966122 @default.
• W1997103498 cites W2112458458 @default.
• W1997103498 cites W2118292263 @default.
• W1997103498 cites W2141848254 @default.
• W1997103498 cites W2321662954 @default.
• W1997103498 cites W2332850050 @default.
• W1997103498 cites W2402073029 @default.
• W1997103498 cites W25675450 @default.
• W1997103498 cites W27072853 @default.
• W1997103498 cites W2979401912 @default.
• W1997103498 cites W4239524546 @default.
• W1997103498 cites W4297924397 @default.
• W1997103498 cites W4301792097 @default.
• W1997103498 doi "https://doi.org/10.1007/s00586-009-1053-2" @default.
• W1997103498 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2899395" @default.
• W1997103498 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19517141" @default.
• W1997103498 hasPublicationYear "2009" @default.
• W1997103498 type Work @default.
• W1997103498 sameAs 1997103498 @default.
• W1997103498 citedByCount "36" @default.
• W1997103498 countsByYear W19971034982013 @default.
• W1997103498 countsByYear W19971034982014 @default.
• W1997103498 countsByYear W19971034982016 @default.
• W1997103498 countsByYear W19971034982017 @default.
• W1997103498 countsByYear W19971034982018 @default.
• W1997103498 countsByYear W19971034982019 @default.
• W1997103498 countsByYear W19971034982020 @default.
• W1997103498 countsByYear W19971034982021 @default.
• W1997103498 countsByYear W19971034982022 @default.
• W1997103498 countsByYear W19971034982023 @default.
• W1997103498 crossrefType "journal-article" @default.
• W1997103498 hasAuthorship W1997103498A5013277398 @default.
• W1997103498 hasAuthorship W1997103498A5040066030 @default.
• W1997103498 hasAuthorship W1997103498A5043026845 @default.
• W1997103498 hasAuthorship W1997103498A5056951156 @default.
• W1997103498 hasBestOaLocation W19971034982 @default.
• W1997103498 hasConcept C104317684 @default.
• W1997103498 hasConcept C105702510 @default.
• W1997103498 hasConcept C128102431 @default.
• W1997103498 hasConcept C142724271 @default.
• W1997103498 hasConcept C159654299 @default.
• W1997103498 hasConcept C189165786 @default.
• W1997103498 hasConcept C203014093 @default.
• W1997103498 hasConcept C204232928 @default.
• W1997103498 hasConcept C204787440 @default.
• W1997103498 hasConcept C205260736 @default.
• W1997103498 hasConcept C2777755357 @default.
• W1997103498 hasConcept C2778051963 @default.
• W1997103498 hasConcept C4224716 @default.
• W1997103498 hasConcept C542903549 @default.
• W1997103498 hasConcept C54355233 @default.
• W1997103498 hasConcept C71924100 @default.
• W1997103498 hasConcept C86803240 @default.
• W1997103498 hasConcept C95444343 @default.
• W1997103498 hasConceptScore W1997103498C104317684 @default.
• W1997103498 hasConceptScore W1997103498C105702510 @default.
• W1997103498 hasConceptScore W1997103498C128102431 @default.
• W1997103498 hasConceptScore W1997103498C142724271 @default.
• W1997103498 hasConceptScore W1997103498C159654299 @default.
• W1997103498 hasConceptScore W1997103498C189165786 @default.
• W1997103498 hasConceptScore W1997103498C203014093 @default.
• W1997103498 hasConceptScore W1997103498C204232928 @default.
• W1997103498 hasConceptScore W1997103498C204787440 @default.
• W1997103498 hasConceptScore W1997103498C205260736 @default.
• W1997103498 hasConceptScore W1997103498C2777755357 @default.
• W1997103498 hasConceptScore W1997103498C2778051963 @default.

• next