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- W1997103667 abstract "Fumonisin B1 (FB1), the major toxin produced by Fusarium verticillioides contaminating corn, is known to elicit many organ- and species-specific toxicities in animals. In the present study, exposure to FB1 decreased viability of a murine macrophage cell line (RAW264.7) in a dose-dependent manner (1–100 μM). Further, when cells exposed to FB1 were stimulated with lipopolysaccharide (LPS), a dose-dependent increase in production of nitric oxide (NO) was observed, but only at FB1 concentrations (10–50 μM) that induced significant cytotoxicity. Stimulation of cells with phorbol myristate acetate (PMA) resulted in increased NO production at 50 μM FB1, but induced a variable NO response at 1–10 μM FB1. Results suggest that FB1 affected cell viability and altered inducible NO production by RAW macrophages in a manner that was dependent on the pathway of stimulation." @default.
- W1997103667 created "2016-06-24" @default.
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- W1997103667 date "2002-07-01" @default.
- W1997103667 modified "2023-09-27" @default.
- W1997103667 title "Fumonisin B1 affects viability and alters nitric oxide production of a murine macrophage cell line" @default.
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- W1997103667 doi "https://doi.org/10.1016/s1567-5769(02)00054-1" @default.
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