Matches in SemOpenAlex for { <https://semopenalex.org/work/W1997110462> ?p ?o ?g. }
Showing items 1 to 82 of
82
with 100 items per page.
- W1997110462 endingPage "889" @default.
- W1997110462 startingPage "883" @default.
- W1997110462 abstract "Research indicates that chronic daily cocaine injections produce sensitization to, while the chronic continuous infusion of cocaine produces tolerance to, its behavioral and neurochemical effects. The present experiments examined whether flupenthixol administration during withdrawal would attenuate/eliminate the behavioral effects produced by these administration regimens. The rats were pretreated for 14 days with either continuous or intermittent daily injections of cocaine, and were then withdrawn from the pretreatment regimen for 7 days. On days 1-5 of the withdrawal period, subjects received a daily 0.125-2.0 mg/kg IP injection of flupenthixol. Then on day 7 of withdrawal from the cocaine pretreatment, all rats were given a 15.0 mg/kg IP injection of cocaine. Their behavior was rated according to a modified version of the Ellinwood and Balster (6) scale for 60 min. The results indicated that flupenthixol treatment during withdrawal eliminated the tolerance normally associated with the continuous infusion of cocaine. However, this effect of flupenthixol was not dose dependent: the lowest dose had the same effect as the highest dose of flupenthixol. In the cocaine-injection subjects, flupenthixol had a slight but statistically significant reduction in the behavioral effects of cocaine. The same was true in the saline-control rats, except for the highest dose of flupenthixol, which had a significant enhancing effect on the behavioral response to cocaine. The present results suggest that the current procedures may represent an effective screening methodology for potential cocaine pharmacotherapies." @default.
- W1997110462 created "2016-06-24" @default.
- W1997110462 creator A5000728450 @default.
- W1997110462 creator A5001911467 @default.
- W1997110462 creator A5040361069 @default.
- W1997110462 date "1994-12-01" @default.
- W1997110462 modified "2023-10-16" @default.
- W1997110462 title "Continuous or intermittent cocaine administration: Effects of flupenthixol treatment during withdrawal" @default.
- W1997110462 cites W1971735649 @default.
- W1997110462 cites W1981062916 @default.
- W1997110462 cites W1998620289 @default.
- W1997110462 cites W2009088798 @default.
- W1997110462 cites W2020397637 @default.
- W1997110462 cites W2030736328 @default.
- W1997110462 cites W2048196882 @default.
- W1997110462 cites W2054721393 @default.
- W1997110462 cites W2060509660 @default.
- W1997110462 cites W2061884588 @default.
- W1997110462 cites W2062218132 @default.
- W1997110462 cites W2066746641 @default.
- W1997110462 cites W2091604090 @default.
- W1997110462 cites W2111325297 @default.
- W1997110462 cites W3026535804 @default.
- W1997110462 cites W4237103110 @default.
- W1997110462 cites W4291747143 @default.
- W1997110462 doi "https://doi.org/10.1016/0091-3057(94)90238-0" @default.
- W1997110462 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8208762" @default.
- W1997110462 hasPublicationYear "1994" @default.
- W1997110462 type Work @default.
- W1997110462 sameAs 1997110462 @default.
- W1997110462 citedByCount "33" @default.
- W1997110462 countsByYear W19971104622012 @default.
- W1997110462 countsByYear W19971104622014 @default.
- W1997110462 countsByYear W19971104622015 @default.
- W1997110462 countsByYear W19971104622019 @default.
- W1997110462 countsByYear W19971104622020 @default.
- W1997110462 crossrefType "journal-article" @default.
- W1997110462 hasAuthorship W1997110462A5000728450 @default.
- W1997110462 hasAuthorship W1997110462A5001911467 @default.
- W1997110462 hasAuthorship W1997110462A5040361069 @default.
- W1997110462 hasConcept C126322002 @default.
- W1997110462 hasConcept C203014093 @default.
- W1997110462 hasConcept C25876315 @default.
- W1997110462 hasConcept C2776217527 @default.
- W1997110462 hasConcept C2777397205 @default.
- W1997110462 hasConcept C2778555786 @default.
- W1997110462 hasConcept C2779985140 @default.
- W1997110462 hasConcept C42219234 @default.
- W1997110462 hasConcept C71924100 @default.
- W1997110462 hasConcept C98274493 @default.
- W1997110462 hasConceptScore W1997110462C126322002 @default.
- W1997110462 hasConceptScore W1997110462C203014093 @default.
- W1997110462 hasConceptScore W1997110462C25876315 @default.
- W1997110462 hasConceptScore W1997110462C2776217527 @default.
- W1997110462 hasConceptScore W1997110462C2777397205 @default.
- W1997110462 hasConceptScore W1997110462C2778555786 @default.
- W1997110462 hasConceptScore W1997110462C2779985140 @default.
- W1997110462 hasConceptScore W1997110462C42219234 @default.
- W1997110462 hasConceptScore W1997110462C71924100 @default.
- W1997110462 hasConceptScore W1997110462C98274493 @default.
- W1997110462 hasIssue "4" @default.
- W1997110462 hasLocation W19971104621 @default.
- W1997110462 hasLocation W19971104622 @default.
- W1997110462 hasOpenAccess W1997110462 @default.
- W1997110462 hasPrimaryLocation W19971104621 @default.
- W1997110462 hasRelatedWork W1569347416 @default.
- W1997110462 hasRelatedWork W1991861361 @default.
- W1997110462 hasRelatedWork W1994671925 @default.
- W1997110462 hasRelatedWork W2041028874 @default.
- W1997110462 hasRelatedWork W2065553801 @default.
- W1997110462 hasRelatedWork W2091951560 @default.
- W1997110462 hasRelatedWork W2116572093 @default.
- W1997110462 hasRelatedWork W2172221866 @default.
- W1997110462 hasRelatedWork W2582609021 @default.
- W1997110462 hasRelatedWork W2740094978 @default.
- W1997110462 hasVolume "49" @default.
- W1997110462 isParatext "false" @default.
- W1997110462 isRetracted "false" @default.
- W1997110462 magId "1997110462" @default.
- W1997110462 workType "article" @default.