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- W1997113432 endingPage "1668" @default.
- W1997113432 startingPage "1659" @default.
- W1997113432 abstract "Sympathetic circulatory control is key to the rapid cardiovascular adjustments that occur within seconds of standing upright (orthostasis) and which are required for bipedal stance. Indeed, patients with ineffective sympathetic adrenergic vasoconstriction rapidly develop orthostatic hypotension, prohibiting effective upright activities. One speaks of orthostatic intolerance (OI) when signs, such as hypotension, and symptoms, such as lightheadedness, occur when upright and are relieved by recumbence. The experience of transient mild OI is part of daily life. However, many people experience episodic acute OI as postural faint or chronic OI in the form of orthostatic tachycardia and orthostatic hypotension that significantly reduce the quality of life. Potential mechanisms for OI are discussed including forms of sympathetic hypofunction, forms of sympathetic hyperfunction, and OI that results from regional blood volume redistribution attributable to regional adrenergic hypofunction." @default.
- W1997113432 created "2016-06-24" @default.
- W1997113432 creator A5032944582 @default.
- W1997113432 date "2012-11-15" @default.
- W1997113432 modified "2023-10-16" @default.
- W1997113432 title "Mechanisms of sympathetic regulation in orthostatic intolerance" @default.
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