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• W1997126502 abstract "A link between Down's syndrome (DS) and Alzheimer disease (AD) is widely recognized. Most individuals with DS will manifest AD by the age of 50. Trisomy 21 results in a 4 to 5-fold increase in expression of the APP gene and accelerated deposition of β-amyloid. Compared to normal controls (NCs), brain imaging studies in late-onset AD (LOAD) have demonstrated increased fibrillar β-amyloid binding and a characteristic and progressive pattern of regional reductions in glucose metabolism and gray matter volume. This study aimed to assess the difference of the measures based on these 3 neuroimaging modalities amongyoung/old DS, DS-with dementia (DSWD), and NC subjects. There were 9 NC (3F, 6M) participants, 12 DS (7F, 5M) participants without dementia, and 5 DSWD (3F, 2M) participants, all consented or assented depending on established capacity. Of the 26 participants enrolled and obtained cognitive testing, 24 participants underwent volumetric MRI, florbetapir PET and FDG-PET. Comparing among the 3 group, DSWD vs. age-matched old DS (n=5) and DSWD vs. young DS (n=5), SPM8 was used for voxel-wise data analysis (FDG, MRI and florbetapir) and predefined regions of interest (ROI) analysis including mean cortical ROI (florbetapir). SUVRs (standard uptake value ratios) for florbetapir data were calculated using pontine as the reference region. Mean cortical-to-pontne florbetapir ROI SUVRs were significantly higher in DSWD subjects than in DS and than in NCs (ANOVA with linear trend) (NC=1.15±0.06, DS=1.27±0.09 and DSWD=1.54±0.21p=0.00002), a findings also confirmed in voxel-wise analysis (p=0.0 01 uncorrected). When compared to age matched DS and young DS patients separately, reductions) in .DSWD patients were observed in temporal-parietal lobes, frontal, and occipital regions known to be preferentially affected by LOAD in terms of both the regional to whole brain metabolism and the regional gray matter (uncorrected P=0.001. Additional frontal reductions were also observed when compared to the young DS subjects. In comparison with DS patients and NCs, DSWD subjects have significantly greater fibrillar Aβ burden, as well as significantly lower glucose metabolism and gray matter volume in AD-affected regions, similar to that observed in LOAD. Additional studies are needed to expand our samples, track these changes over time, and provide sample size estimates for clinical and preclinical AD trials in patients with DS." @default.
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• W1997126502 date "2013-07-01" @default.
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• W1997126502 title "P1-358: Florbetapir PET, FDG-PET and MRI in people with Down syndrome with and without symptomatic Alzheimer's disease" @default.
• W1997126502 doi "https://doi.org/10.1016/j.jalz.2013.05.585" @default.
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