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- W1997137788 abstract "It is now generally accepted that cells are as responsive to their mechanical environment as they are to biochemical stimuli. As reported recently, human mesenchymal stem cells (hMSCs) plated on collagen-coated gels with a Young's modulus E = 1, 11, and 34 kPa, differentiate towards the neurogenic, myogenic, and osteogenic lineage, respectively [Engler AJ et al. Cell 126(4):677-89 2006]. This mechano-sensing is non-muscle myosin II (NMM II) dependent as shown with the potent inhibitor blebbistatin. While up-regulation of specific proteins occurs on the time scale of several days, the MSCs already show significantly different morphologies several hours after initial cell adhesion. We present experimental data and a theoretical model to explain the non-monotonic dependence of stress-fiber polarization in MSCs on matrix elasticity. The cytoskeletal organization is analyzed with immunofluorescence images of NMM IIa and actin in the cells at various time points using an automated segmentation algorithm. The theory generalizes the treatment of elastic inclusions in solids to “living” inclusions (cells) whose active polarizability, analogous to the polarizability of non-living matter, results in the feedback of cellular forces that develop in response to matrix stresses. This study demonstrates that matrix rigidity dictates cytoskeletal organization - a bio-mechanical process that results in different cell shapes and finally leads to differentiation." @default.
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- W1997137788 date "2009-02-01" @default.
- W1997137788 modified "2023-09-29" @default.
- W1997137788 title "Matrix Elasticity Dictates Cytoskeletal Polarization In Mesenchymal Stem Cells" @default.
- W1997137788 doi "https://doi.org/10.1016/j.bpj.2008.12.3315" @default.
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