FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1997144071> ?p ?o ?g. }

• W1997144071 endingPage "88" @default.
• W1997144071 startingPage "83" @default.
• W1997144071 abstract "Reactivity to stressors and environmental cues, a putative cause of relapse in addiction, may be a useful target for relapse-prevention medication. In rodents, alpha-2 adrenergic agonists such as clonidine block stress-induced reinstatement of drug seeking, but not drug cue-induced reinstatement.The objective of this study is to test the effect of clonidine on stress- and cue-induced craving in human cocaine users.Healthy, non-treatment-seeking cocaine users (n = 59) were randomly assigned to three groups receiving clonidine 0, 0.1, or 0.2 mg orally under double-blind conditions. In a single test session, each participant received clonidine or placebo followed 3 h later by exposure to two pairs of standardized auditory-imagery scripts (neutral/stress and neutral/drug). Subjective measures of craving were collected.Subjective responsivity (crave cocaine Visual Analog Scale) to stress scripts was significantly attenuated in the 0.1- and 0.2-mg clonidine groups; for drug-cue scripts, this attenuation occurred only in the 0.2-mg group. Other subjective measures of craving showed similar patterns of effects but Dose × Script interactions were not significant.Clonidine was effective in reducing stress-induced (and, at a higher dose, cue-induced) craving in a pattern consistent with preclinical findings, although this was significant on only one of several measures. Our results, though modest and preliminary, converge with other evidence to suggest that alpha-2 adrenergic agonists may help prevent relapse in drug abusers experiencing stress or situations that remind them of drug use." @default.
• W1997144071 created "2016-06-24" @default.
• W1997144071 creator A5009057770 @default.
• W1997144071 creator A5034322691 @default.
• W1997144071 creator A5040672500 @default.
• W1997144071 creator A5054057124 @default.
• W1997144071 creator A5060972692 @default.
• W1997144071 creator A5091344622 @default.
• W1997144071 date "2011-03-12" @default.
• W1997144071 modified "2023-10-16" @default.
• W1997144071 title "Clonidine blocks stress-induced craving in cocaine users" @default.
• W1997144071 cites W1585919129 @default.
• W1997144071 cites W1593759117 @default.
• W1997144071 cites W1966533004 @default.
• W1997144071 cites W1974940240 @default.
• W1997144071 cites W1983960474 @default.
• W1997144071 cites W1984346427 @default.
• W1997144071 cites W1988132969 @default.
• W1997144071 cites W1989167816 @default.
• W1997144071 cites W1997116342 @default.
• W1997144071 cites W2006998905 @default.
• W1997144071 cites W2028219379 @default.
• W1997144071 cites W2033414868 @default.
• W1997144071 cites W2033584583 @default.
• W1997144071 cites W2043559838 @default.
• W1997144071 cites W2048756351 @default.
• W1997144071 cites W2053006303 @default.
• W1997144071 cites W2060090253 @default.
• W1997144071 cites W2062220201 @default.
• W1997144071 cites W2074615095 @default.
• W1997144071 cites W2086265757 @default.
• W1997144071 cites W2091200481 @default.
• W1997144071 cites W2096665058 @default.
• W1997144071 cites W2098304576 @default.
• W1997144071 cites W2105024315 @default.
• W1997144071 cites W2108849121 @default.
• W1997144071 cites W2113753462 @default.
• W1997144071 cites W2126189142 @default.
• W1997144071 cites W2163989393 @default.
• W1997144071 cites W2171282854 @default.
• W1997144071 cites W4234810743 @default.
• W1997144071 cites W4248290997 @default.
• W1997144071 cites W4248340768 @default.
• W1997144071 cites W4292994367 @default.
• W1997144071 doi "https://doi.org/10.1007/s00213-011-2230-7" @default.
• W1997144071 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3401928" @default.
• W1997144071 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21399902" @default.
• W1997144071 hasPublicationYear "2011" @default.
• W1997144071 type Work @default.
• W1997144071 sameAs 1997144071 @default.
• W1997144071 citedByCount "71" @default.
• W1997144071 countsByYear W19971440712012 @default.
• W1997144071 countsByYear W19971440712013 @default.
• W1997144071 countsByYear W19971440712014 @default.
• W1997144071 countsByYear W19971440712015 @default.
• W1997144071 countsByYear W19971440712016 @default.
• W1997144071 countsByYear W19971440712017 @default.
• W1997144071 countsByYear W19971440712018 @default.
• W1997144071 countsByYear W19971440712019 @default.
• W1997144071 countsByYear W19971440712020 @default.
• W1997144071 countsByYear W19971440712021 @default.
• W1997144071 countsByYear W19971440712022 @default.
• W1997144071 countsByYear W19971440712023 @default.
• W1997144071 crossrefType "journal-article" @default.
• W1997144071 hasAuthorship W1997144071A5009057770 @default.
• W1997144071 hasAuthorship W1997144071A5034322691 @default.
• W1997144071 hasAuthorship W1997144071A5040672500 @default.
• W1997144071 hasAuthorship W1997144071A5054057124 @default.
• W1997144071 hasAuthorship W1997144071A5060972692 @default.
• W1997144071 hasAuthorship W1997144071A5091344622 @default.
• W1997144071 hasBestOaLocation W19971440712 @default.
• W1997144071 hasConcept C118552586 @default.
• W1997144071 hasConcept C142724271 @default.
• W1997144071 hasConcept C15744967 @default.
• W1997144071 hasConcept C204787440 @default.
• W1997144071 hasConcept C27081682 @default.
• W1997144071 hasConcept C2778399450 @default.
• W1997144071 hasConcept C2779541405 @default.
• W1997144071 hasConcept C42219234 @default.
• W1997144071 hasConcept C48856860 @default.
• W1997144071 hasConcept C548259974 @default.
• W1997144071 hasConcept C71924100 @default.
• W1997144071 hasConceptScore W1997144071C118552586 @default.
• W1997144071 hasConceptScore W1997144071C142724271 @default.
• W1997144071 hasConceptScore W1997144071C15744967 @default.
• W1997144071 hasConceptScore W1997144071C204787440 @default.
• W1997144071 hasConceptScore W1997144071C27081682 @default.
• W1997144071 hasConceptScore W1997144071C2778399450 @default.
• W1997144071 hasConceptScore W1997144071C2779541405 @default.
• W1997144071 hasConceptScore W1997144071C42219234 @default.
• W1997144071 hasConceptScore W1997144071C48856860 @default.
• W1997144071 hasConceptScore W1997144071C548259974 @default.
• W1997144071 hasConceptScore W1997144071C71924100 @default.
• W1997144071 hasIssue "1" @default.
• W1997144071 hasLocation W19971440711 @default.
• W1997144071 hasLocation W19971440712 @default.
• W1997144071 hasLocation W19971440713 @default.
• W1997144071 hasLocation W19971440714 @default.

• next