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• W1997145468 abstract "<i>Background:</i> We evaluated the impact of the three major genetic polymorphisms of the renin-angiotensin system [angiotensinogen (AGT) gene M235T, angiotensin-converting enzyme (ACE) gene-I/D and angiotensin II-type 1 receptor (AT₁R) gene A1166C polymorphisms] as risk factors in IgA nephropathy. <i>Methods:</i> The clinical course of 107 patients with biopsy proven IgA nephropathy followed up for 6.6 ± 5.8 years was examined. The genetic polymorphisms were determined by PCR amplification. <i>Results:</i> The allele frequencies of the polymorphisms studied were similar in patients and control subjects. AGT-M235T genotype was associated with the presence of nephrotic syndrome (p < 0.05), correlated to the number of antihypertensive drugs agents taken (p < 0.01) and influenced the rate of deterioration of renal function (p < 0.05). Combined analysis of AGT-M235T and ACE-I/D polymorphisms detected an interaction on affecting progression (p < 0.05). ACE-inhibition had a more pronounced effect in certain AGT-M235T and ACE-I/D genotypes (p < 0.05) and their combined analysis showed a synergistic effect (p < 0.01). No association between AT₁R-A1166C polymorphism and any of the parameters studied was observed. <i>Conclusions:</i> Our results suggest that angiotensinogen-M235T polymorphism is an important marker of progression in IgA nephropathy in Caucasian patients, especially when analyzed in combination with ACE-I/D polymorphism." @default.
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• W1997145468 date "2004-01-01" @default.
• W1997145468 modified "2023-09-23" @default.
• W1997145468 title "Influence of Genetic Polymorphisms of the Renin-Angiotensin System on IgA Nephropathy" @default.
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• W1997145468 doi "https://doi.org/10.1159/000077398" @default.
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