FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1997146459> ?p ?o ?g. }

• W1997146459 endingPage "3129" @default.
• W1997146459 startingPage "3121" @default.
• W1997146459 abstract "To investigate the effects of disease and intensive chemotherapy on bone turnover and growth in children with acute lymphoblastic leukemia (ALL), a longitudinal prospective study was carried out in 22 children, aged 1.2-13.5 yr, enrolled in the Medical Research Council-funded randomized trial of childhood ALL treatment in the UK. We measured lower leg length and markers of bone formation [bone alkaline phosphatase (ALP) and procollagen type I C-terminal propeptide (PICP)], bone resorption [pyridinoline, deoxypyridinoline, and carboxyl-terminal telopeptide of type I collagen (ICTP)], soft tissue turnover [procollagen type III N-terminal propeptide (P3NP)], and the GH axis [IGF-I, IGF-binding protein-3 (IGFBP-3), IGFBP-2, and urinary GH] at 1- to 4-week intervals from diagnosis to week 27 of treatment. In addition, GH-binding protein was measured at diagnosis. At diagnosis, mean SD scores were: bone ALP, -1.84; PICP -1.77; pyridinoline, -1.42; deoxypyridinoline, -1.66; ICTP, -0.42; P3NP, +1.45; GH, +24.4; IGF-I, -1.70; IGFBP-3, -0.88; IGFBP-2, +2.42; and GH-binding protein, -0.69. Bone ALP, PICP, and IGFBP-3 were all correlated (P < or = 0.03). During induction and intensification, there was shrinkage of the lower leg, with decreases in PICP, pyridinoline, ICTP, and P3NP (P < 0.05), whereas IGF-I and IGFBP-3 increased (P < 0.05). After prednisolone was discontinued, bone ALP and collagen markers increased markedly (P < 0.01), but there was no significant change in IGF-I and IGFBP-3. In 12 children who received high dose i.v. methotrexate, postglucocorticoid increases in bone ALP and PICP were less, whereas those in ICTP and P3NP were greater, compared to levels in children who did not receive methotrexate (P < 0.05). We conclude that ALL itself caused GH resistance and low bone turnover. During early intensive chemotherapy, further suppression of osteoblast proliferation and osteoclast activity occurred, not mediated through the systemic GH axis, probably by the direct action of prednisolone on bone. The postglucocorticoid increase in bone turnover was also independent of the GH axis and was modulated by high dose i.v. methotrexate, which depressed osteoblast recovery and enhanced osteoclast activity." @default.
• W1997146459 created "2016-06-24" @default.
• W1997146459 creator A5025605160 @default.
• W1997146459 creator A5026290327 @default.
• W1997146459 creator A5038570653 @default.
• W1997146459 creator A5049852391 @default.
• W1997146459 creator A5049949552 @default.
• W1997146459 creator A5085030460 @default.
• W1997146459 creator A5085109291 @default.
• W1997146459 creator A5090448936 @default.
• W1997146459 date "1998-09-01" @default.
• W1997146459 modified "2023-09-26" @default.
• W1997146459 title "Effects of Intensive Chemotherapy on Bone and Collagen Turnover and the Growth Hormone Axis in Children with Acute Lymphoblastic Leukemia¹" @default.
• W1997146459 cites W116867690 @default.
• W1997146459 cites W1858726777 @default.
• W1997146459 cites W1887241598 @default.
• W1997146459 cites W1937218054 @default.
• W1997146459 cites W1969887147 @default.
• W1997146459 cites W1974914120 @default.
• W1997146459 cites W1978041015 @default.
• W1997146459 cites W1979442279 @default.
• W1997146459 cites W1989578013 @default.
• W1997146459 cites W1989908968 @default.
• W1997146459 cites W1990470011 @default.
• W1997146459 cites W1991711716 @default.
• W1997146459 cites W1996676405 @default.
• W1997146459 cites W1997350918 @default.
• W1997146459 cites W2000293700 @default.
• W1997146459 cites W2002000090 @default.
• W1997146459 cites W2005197142 @default.
• W1997146459 cites W2005206208 @default.
• W1997146459 cites W2006231337 @default.
• W1997146459 cites W2017194813 @default.
• W1997146459 cites W2018374241 @default.
• W1997146459 cites W2026058273 @default.
• W1997146459 cites W2030390844 @default.
• W1997146459 cites W2030788873 @default.
• W1997146459 cites W2030795608 @default.
• W1997146459 cites W2038621138 @default.
• W1997146459 cites W2040137331 @default.
• W1997146459 cites W2041952670 @default.
• W1997146459 cites W2042486467 @default.
• W1997146459 cites W2048237871 @default.
• W1997146459 cites W2048258524 @default.
• W1997146459 cites W2049775904 @default.
• W1997146459 cites W2065156547 @default.
• W1997146459 cites W2067759023 @default.
• W1997146459 cites W2073423688 @default.
• W1997146459 cites W2074885296 @default.
• W1997146459 cites W2074889809 @default.
• W1997146459 cites W2075958495 @default.
• W1997146459 cites W2079040883 @default.
• W1997146459 cites W2081632005 @default.
• W1997146459 cites W2082392098 @default.
• W1997146459 cites W2088874555 @default.
• W1997146459 cites W2092212028 @default.
• W1997146459 cites W2092702424 @default.
• W1997146459 cites W2093312406 @default.
• W1997146459 cites W2105873677 @default.
• W1997146459 cites W2114787572 @default.
• W1997146459 cites W2122200307 @default.
• W1997146459 cites W2128118061 @default.
• W1997146459 cites W2131364728 @default.
• W1997146459 cites W2145110695 @default.
• W1997146459 cites W2171385985 @default.
• W1997146459 cites W2211280032 @default.
• W1997146459 cites W2261175572 @default.
• W1997146459 cites W2434837298 @default.
• W1997146459 cites W2256906942 @default.
• W1997146459 doi "https://doi.org/10.1210/jcem.83.9.5133" @default.
• W1997146459 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9745414" @default.
• W1997146459 hasPublicationYear "1998" @default.
• W1997146459 type Work @default.
• W1997146459 sameAs 1997146459 @default.
• W1997146459 citedByCount "42" @default.
• W1997146459 countsByYear W19971464592012 @default.
• W1997146459 countsByYear W19971464592013 @default.
• W1997146459 countsByYear W19971464592014 @default.
• W1997146459 countsByYear W19971464592015 @default.
• W1997146459 countsByYear W19971464592016 @default.
• W1997146459 countsByYear W19971464592017 @default.
• W1997146459 countsByYear W19971464592018 @default.
• W1997146459 countsByYear W19971464592019 @default.
• W1997146459 countsByYear W19971464592022 @default.
• W1997146459 countsByYear W19971464592023 @default.
• W1997146459 crossrefType "journal-article" @default.
• W1997146459 hasAuthorship W1997146459A5025605160 @default.
• W1997146459 hasAuthorship W1997146459A5026290327 @default.
• W1997146459 hasAuthorship W1997146459A5038570653 @default.
• W1997146459 hasAuthorship W1997146459A5049852391 @default.
• W1997146459 hasAuthorship W1997146459A5049949552 @default.
• W1997146459 hasAuthorship W1997146459A5085030460 @default.
• W1997146459 hasAuthorship W1997146459A5085109291 @default.
• W1997146459 hasAuthorship W1997146459A5090448936 @default.
• W1997146459 hasBestOaLocation W19971464591 @default.
• W1997146459 hasConcept C125870589 @default.
• W1997146459 hasConcept C126322002 @default.
• W1997146459 hasConcept C131075544 @default.

• next