Matches in SemOpenAlex for { <https://semopenalex.org/work/W1997148030> ?p ?o ?g. }
Showing items 1 to 99 of
99
with 100 items per page.
- W1997148030 endingPage "83" @default.
- W1997148030 startingPage "77" @default.
- W1997148030 abstract "A microsatellite assay was used to screen 31 potentially malignant oral lesions presenting as leukoplakia and erythroplakia, with histological evidence of dysplasia, for genetic abnormalities at loci which frequently show allelic imbalance when oral squamous cell carcinomas (SCC) are examined. The microsatellite and restriction fragment length polymorphism (RFLP) markers selected were at 3p21, 8p21-23, 9p21 and included sequences within the Rb (13q14.2), p53 (17p13.1) and DCC (18q21.1) tumour suppressor genes. 8 patients subsequently developed an invasive tumour at the same site, or within 2 cm of the premalignant lesion. A further 8 patients developed SCC at a distant site. Seventy-seven per cent (24/31) of these potentially malignant lesions showed allelic imbalance (AI) and 55% (17/31) of cases showed microsatellite instability (msi). The probability of developing SCC was much greater for patients with lesions showing AI at two or more relevant loci (P = 0.008 by the logrank test) than the group with AI at fewer loci. The estimated probability of development of SCC in this group by 5 years was 73% (95% Cl: 50-92%). This suggests that determining the number of genetic abnormalities in a potentially malignant lesion can help identify patients with true precancers who should be followed closely to ensure that they receive chemoprevention and appropriate advice to limit risk factors, and to allow the early detection of invasive lesions." @default.
- W1997148030 created "2016-06-24" @default.
- W1997148030 creator A5003927093 @default.
- W1997148030 creator A5035318705 @default.
- W1997148030 creator A5040230797 @default.
- W1997148030 creator A5042905435 @default.
- W1997148030 creator A5044259820 @default.
- W1997148030 creator A5070024965 @default.
- W1997148030 date "1998-03-01" @default.
- W1997148030 modified "2023-10-09" @default.
- W1997148030 title "Allelic imbalance at chromosomal loci implicated in the pathogenesis of oral precancer, cumulative loss and its relationship with progression to cancer" @default.
- W1997148030 cites W1964947899 @default.
- W1997148030 cites W1978800919 @default.
- W1997148030 cites W2006058060 @default.
- W1997148030 cites W2014423008 @default.
- W1997148030 cites W2040535584 @default.
- W1997148030 cites W2051142747 @default.
- W1997148030 cites W2060240542 @default.
- W1997148030 cites W2061028918 @default.
- W1997148030 cites W2067795112 @default.
- W1997148030 cites W2086698289 @default.
- W1997148030 cites W2089576257 @default.
- W1997148030 cites W2095133202 @default.
- W1997148030 doi "https://doi.org/10.1016/s1368-8375(97)00052-3" @default.
- W1997148030 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9682768" @default.
- W1997148030 hasPublicationYear "1998" @default.
- W1997148030 type Work @default.
- W1997148030 sameAs 1997148030 @default.
- W1997148030 citedByCount "84" @default.
- W1997148030 countsByYear W19971480302012 @default.
- W1997148030 countsByYear W19971480302013 @default.
- W1997148030 countsByYear W19971480302014 @default.
- W1997148030 countsByYear W19971480302015 @default.
- W1997148030 countsByYear W19971480302016 @default.
- W1997148030 countsByYear W19971480302018 @default.
- W1997148030 countsByYear W19971480302021 @default.
- W1997148030 countsByYear W19971480302022 @default.
- W1997148030 countsByYear W19971480302023 @default.
- W1997148030 crossrefType "journal-article" @default.
- W1997148030 hasAuthorship W1997148030A5003927093 @default.
- W1997148030 hasAuthorship W1997148030A5035318705 @default.
- W1997148030 hasAuthorship W1997148030A5040230797 @default.
- W1997148030 hasAuthorship W1997148030A5042905435 @default.
- W1997148030 hasAuthorship W1997148030A5044259820 @default.
- W1997148030 hasAuthorship W1997148030A5070024965 @default.
- W1997148030 hasConcept C104317684 @default.
- W1997148030 hasConcept C121608353 @default.
- W1997148030 hasConcept C142724271 @default.
- W1997148030 hasConcept C143589142 @default.
- W1997148030 hasConcept C180754005 @default.
- W1997148030 hasConcept C203014093 @default.
- W1997148030 hasConcept C2775894508 @default.
- W1997148030 hasConcept C2777550702 @default.
- W1997148030 hasConcept C2779767149 @default.
- W1997148030 hasConcept C2780942790 @default.
- W1997148030 hasConcept C2781156865 @default.
- W1997148030 hasConcept C54355233 @default.
- W1997148030 hasConcept C61320498 @default.
- W1997148030 hasConcept C71924100 @default.
- W1997148030 hasConcept C86803240 @default.
- W1997148030 hasConcept C90924648 @default.
- W1997148030 hasConceptScore W1997148030C104317684 @default.
- W1997148030 hasConceptScore W1997148030C121608353 @default.
- W1997148030 hasConceptScore W1997148030C142724271 @default.
- W1997148030 hasConceptScore W1997148030C143589142 @default.
- W1997148030 hasConceptScore W1997148030C180754005 @default.
- W1997148030 hasConceptScore W1997148030C203014093 @default.
- W1997148030 hasConceptScore W1997148030C2775894508 @default.
- W1997148030 hasConceptScore W1997148030C2777550702 @default.
- W1997148030 hasConceptScore W1997148030C2779767149 @default.
- W1997148030 hasConceptScore W1997148030C2780942790 @default.
- W1997148030 hasConceptScore W1997148030C2781156865 @default.
- W1997148030 hasConceptScore W1997148030C54355233 @default.
- W1997148030 hasConceptScore W1997148030C61320498 @default.
- W1997148030 hasConceptScore W1997148030C71924100 @default.
- W1997148030 hasConceptScore W1997148030C86803240 @default.
- W1997148030 hasConceptScore W1997148030C90924648 @default.
- W1997148030 hasIssue "2" @default.
- W1997148030 hasLocation W19971480301 @default.
- W1997148030 hasLocation W19971480302 @default.
- W1997148030 hasOpenAccess W1997148030 @default.
- W1997148030 hasPrimaryLocation W19971480301 @default.
- W1997148030 hasRelatedWork W1975299549 @default.
- W1997148030 hasRelatedWork W1988340380 @default.
- W1997148030 hasRelatedWork W2067182044 @default.
- W1997148030 hasRelatedWork W2067665082 @default.
- W1997148030 hasRelatedWork W2086717873 @default.
- W1997148030 hasRelatedWork W2166534946 @default.
- W1997148030 hasRelatedWork W2348751509 @default.
- W1997148030 hasRelatedWork W2473005840 @default.
- W1997148030 hasRelatedWork W2969016060 @default.
- W1997148030 hasRelatedWork W4233420018 @default.
- W1997148030 hasVolume "34" @default.
- W1997148030 isParatext "false" @default.
- W1997148030 isRetracted "false" @default.
- W1997148030 magId "1997148030" @default.
- W1997148030 workType "article" @default.