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- W1997150980 abstract "Abstract Objective In this study we investigate the quantitative diffusion tensor imaging (DTI) changes of normal-appearing white matter (NAWM) in patients with stage 0 asymptomatic HIV-1 associated dementia complex (HAD), and clinical factors contributing to it. Materials and methods Conventional magnetic resonance imaging (cMRI) and DTI were performed in 40 patients with stage 0 asymptomatic HAD (24 patients with CD4 + counts 3 , 16 patients with CD4 + counts >200 cells/mm 3 ) and 40 healthy volunteers with similar gender/age. Quantitative DTI values-fractional anisotropy (FA)/apparent diffusion coefficient (ADC) of normal-appearing white matter (NAWM) in frontal, parietal, temporal, occipital lobes, genu, splenium and body of the corpus callosum (CC), corona radiate (CR), centrum semiovale (CSO), and anterior and posterior limbs of the internal capsule were measured and analyzed. Results The mean FA values were much lower and the mean ADC values were significantly higher in the CC body and CSO in stage 0 HAD patients than in the controls ( P P P > 0.05). FA values were reduced and ADC values were higher in other white matter regions, but did not show any significant difference between the two groups ( P > 0.05). Significantly higher ADC values in the frontal and CR in patients with CD4 + counts 3 compared with the patients with CD4 + counts >200 cells/mm 3 and the controls. Conclusions Quantitative DTI could help better evaluation of white matter abnormalities in stage 0 asymptomatic HAD, this may be helpful for early and accurate prevention and treatment of HAD, and for preventing or reversing cognitive decline. The quantitative DTI value changes indicated that in early phase of HAD there is a preferential occult injury of frontal lobe and CSO. Nadir CD4 + count may be a great risk for HAD." @default.
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- W1997150980 date "2014-12-01" @default.
- W1997150980 modified "2023-09-23" @default.
- W1997150980 title "White matter damage and effects of nadir CD4+ count on patients with asymptomatic HIV associated dementia complex–A DTI study" @default.
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- W1997150980 doi "https://doi.org/10.1016/j.jrid.2014.10.005" @default.
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