FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1997156788> ?p ?o ?g. }

• W1997156788 endingPage "1103" @default.
• W1997156788 startingPage "1094" @default.
• W1997156788 abstract "Acute severe ulcerative colitis (ASUC), the most aggressive presentation of ulcerative colitis (UC), occurs in 15% of adults and children with UC. First line therapy with intravenous corticosteroids is ineffective in half of adults and one-third of children. Therapeutic monoclonal antibodies against TNF (anti-TNF therapy) are emerging as a common treatment for ASUC due to their similar efficacy to calcineurin inhibitors and more favourable adverse effect profile.To comprehensively review the evidence for anti-TNF therapy for ASUC in children and adults with regard to outcomes and pharmacokinetics.PubMed and recent conference proceedings were searched using the terms 'ulcerative colitis', 'acute severe ulcerative colitis', 'anti-TNF', 'pharmacokinetics' and the generic names of specific anti-TNF agents.Outcomes after anti-TNF therapy for ASUC remain suboptimal with about one half of children and adults undergoing colectomy. While several randomised controlled trials have demonstrated the efficacy of anti-TNF therapy for ambulatory patients with moderate to severely active UC, patients in these studies were less ill than those with ASUC. Patients with ASUC may exhibit more rapid clearance of anti-TNF biologics due to pharmacokinetic mechanisms influenced by disease severity.Conventional weight-based dosing effective in patients with moderately to severely active UC, may not be equally effective in those with acute severe ulcerative colitis. Personalised anti-TNF dosing strategies, which integrate patient factors and early measures of pharmacokinetics and response, hold promise for ensuring sustained drug exposure and maximising early mucosal healing in patients with acute severe ulcerative colitis." @default.
• W1997156788 created "2016-06-24" @default.
• W1997156788 creator A5040060343 @default.
• W1997156788 creator A5051483318 @default.
• W1997156788 creator A5053271325 @default.
• W1997156788 date "2015-03-23" @default.
• W1997156788 modified "2023-10-17" @default.
• W1997156788 title "Review article: applying pharmacokinetics to optimise dosing of anti‐TNF biologics in acute severe ulcerative colitis" @default.
• W1997156788 cites W1490277221 @default.
• W1997156788 cites W1565354477 @default.
• W1997156788 cites W1573635904 @default.
• W1997156788 cites W1970524014 @default.
• W1997156788 cites W1970875728 @default.
• W1997156788 cites W1973716870 @default.
• W1997156788 cites W1976363289 @default.
• W1997156788 cites W1981017999 @default.
• W1997156788 cites W1982704769 @default.
• W1997156788 cites W1984292823 @default.
• W1997156788 cites W1984490593 @default.
• W1997156788 cites W1984705525 @default.
• W1997156788 cites W1987925515 @default.
• W1997156788 cites W1993384587 @default.
• W1997156788 cites W2004608617 @default.
• W1997156788 cites W2005049926 @default.
• W1997156788 cites W2006783956 @default.
• W1997156788 cites W2012706253 @default.
• W1997156788 cites W2013201041 @default.
• W1997156788 cites W2014239382 @default.
• W1997156788 cites W2015172885 @default.
• W1997156788 cites W2022413885 @default.
• W1997156788 cites W2023733628 @default.
• W1997156788 cites W2025386944 @default.
• W1997156788 cites W2027142766 @default.
• W1997156788 cites W2043545267 @default.
• W1997156788 cites W2043973362 @default.
• W1997156788 cites W2044160586 @default.
• W1997156788 cites W2047852273 @default.
• W1997156788 cites W2051123343 @default.
• W1997156788 cites W2054112855 @default.
• W1997156788 cites W2057220303 @default.
• W1997156788 cites W2063901570 @default.
• W1997156788 cites W2067773009 @default.
• W1997156788 cites W2068255175 @default.
• W1997156788 cites W2071644653 @default.
• W1997156788 cites W2071871684 @default.
• W1997156788 cites W2076523377 @default.
• W1997156788 cites W2079295802 @default.
• W1997156788 cites W2084154110 @default.
• W1997156788 cites W2086328014 @default.
• W1997156788 cites W2087726829 @default.
• W1997156788 cites W2088135039 @default.
• W1997156788 cites W2090343834 @default.
• W1997156788 cites W2094464340 @default.
• W1997156788 cites W2095161324 @default.
• W1997156788 cites W2098011105 @default.
• W1997156788 cites W2099169909 @default.
• W1997156788 cites W2102897127 @default.
• W1997156788 cites W2103755206 @default.
• W1997156788 cites W2104097403 @default.
• W1997156788 cites W2111362292 @default.
• W1997156788 cites W2116569898 @default.
• W1997156788 cites W2129038122 @default.
• W1997156788 cites W2136560153 @default.
• W1997156788 cites W2143710323 @default.
• W1997156788 cites W2144518079 @default.
• W1997156788 cites W2145245891 @default.
• W1997156788 cites W2146692972 @default.
• W1997156788 cites W2146963207 @default.
• W1997156788 cites W2159719279 @default.
• W1997156788 cites W2168755239 @default.
• W1997156788 cites W2171297959 @default.
• W1997156788 cites W2318177842 @default.
• W1997156788 cites W2324390810 @default.
• W1997156788 cites W2330655337 @default.
• W1997156788 cites W4245568550 @default.
• W1997156788 cites W627574825 @default.
• W1997156788 doi "https://doi.org/10.1111/apt.13175" @default.
• W1997156788 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4498660" @default.
• W1997156788 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25809869" @default.
• W1997156788 hasPublicationYear "2015" @default.
• W1997156788 type Work @default.
• W1997156788 sameAs 1997156788 @default.
• W1997156788 citedByCount "86" @default.
• W1997156788 countsByYear W19971567882015 @default.
• W1997156788 countsByYear W19971567882016 @default.
• W1997156788 countsByYear W19971567882017 @default.
• W1997156788 countsByYear W19971567882018 @default.
• W1997156788 countsByYear W19971567882019 @default.
• W1997156788 countsByYear W19971567882020 @default.
• W1997156788 countsByYear W19971567882021 @default.
• W1997156788 countsByYear W19971567882022 @default.
• W1997156788 countsByYear W19971567882023 @default.
• W1997156788 crossrefType "journal-article" @default.
• W1997156788 hasAuthorship W1997156788A5040060343 @default.
• W1997156788 hasAuthorship W1997156788A5051483318 @default.
• W1997156788 hasAuthorship W1997156788A5053271325 @default.
• W1997156788 hasBestOaLocation W19971567881 @default.
• W1997156788 hasConcept C112705442 @default.

• next