FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1997162550> ?p ?o ?g. }

• W1997162550 endingPage "825" @default.
• W1997162550 startingPage "819" @default.
• W1997162550 abstract "Morphea or localized scleroderma is a relatively rare disease whose main symptom is excessive skin fibrosis. Here we focus on the involvement of human endogenous retroviruses (HERVs) in morphea. The HERVs are a vast and intensely growing field in genomics. HERVs are of special interest as far as autoimmune disorders are concerned, yet little effort has been made until now to assess the possible changes of their expression in morphea.Six sequences of particular interest were chosen for this study. Real-time polymerase chain reaction was performed on samples derived from peripheral blood mononuclear cells (PBMCs) and skin biopsies. The results were normalized to the level of glyceraldehyde 3-phosphate dehydrogenase (GAPDH) transcription.In PBMCs we found a statistically significant decrease of transcription of HERV-E pol, while HERV-K env, HERV-R pol-env, and HERV-W env were found to be up-regulated. In skin biopsies HERV-K env was strongly up-regulated. On the other hand, we noted a decrease of transcription of HERV-H env 62, HERV-K10 gag, HERV-R pol-env, and HERV-W env. In PBMCs we found a statistically significant decrease of transcription of HERV-E pol (-81.8%, p < 0.001), while HERV-K env (+94.1%, p = 0.010), HERV-R pol-env (+140.0%, p < 0.001), and HERV-W env (+97.7%, p < 0.001) were found to be up-regulated. In skin biopsies HERV-K env was strongly up-regulated (+713.0%, p = 0.003). On the other hand, we noted a decrease of transcription of HERV-H env 62 (-83.5%, p < 0.001, HERV-K10 gag (-33.7%, p = 0.044), HERV-R pol-env (-71.3%, p < 0.001), and HERV-W env (-59.3%, p = 0.029).The studied HERV sequences generally show an increase of transcription in PBMCs of morphea patients, while being down-regulated in their skin, with some exceptions for both types of tissue." @default.
• W1997162550 created "2016-06-24" @default.
• W1997162550 creator A5012796989 @default.
• W1997162550 creator A5049051702 @default.
• W1997162550 creator A5052566514 @default.
• W1997162550 creator A5066013303 @default.
• W1997162550 creator A5075212481 @default.
• W1997162550 creator A5083690640 @default.
• W1997162550 date "2012-01-01" @default.
• W1997162550 modified "2023-10-03" @default.
• W1997162550 title "Expression of selected human endogenous retroviral sequences in skin and peripheral blood mononuclear cells in morphea" @default.
• W1997162550 cites W1479917820 @default.
• W1997162550 cites W1767157475 @default.
• W1997162550 cites W1894380633 @default.
• W1997162550 cites W1947893030 @default.
• W1997162550 cites W1988095531 @default.
• W1997162550 cites W2013180512 @default.
• W1997162550 cites W2018438835 @default.
• W1997162550 cites W2048674643 @default.
• W1997162550 cites W2074378857 @default.
• W1997162550 cites W2103608005 @default.
• W1997162550 cites W2118918059 @default.
• W1997162550 cites W2134812217 @default.
• W1997162550 cites W2143045093 @default.
• W1997162550 cites W2158692477 @default.
• W1997162550 cites W2165834027 @default.
• W1997162550 cites W2183929602 @default.
• W1997162550 cites W2409408585 @default.
• W1997162550 cites W2605208871 @default.
• W1997162550 doi "https://doi.org/10.5114/aoms.2012.30954" @default.
• W1997162550 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3506226" @default.
• W1997162550 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23185190" @default.
• W1997162550 hasPublicationYear "2012" @default.
• W1997162550 type Work @default.
• W1997162550 sameAs 1997162550 @default.
• W1997162550 citedByCount "20" @default.
• W1997162550 countsByYear W19971625502012 @default.
• W1997162550 countsByYear W19971625502013 @default.
• W1997162550 countsByYear W19971625502014 @default.
• W1997162550 countsByYear W19971625502015 @default.
• W1997162550 countsByYear W19971625502016 @default.
• W1997162550 countsByYear W19971625502017 @default.
• W1997162550 countsByYear W19971625502018 @default.
• W1997162550 countsByYear W19971625502019 @default.
• W1997162550 countsByYear W19971625502020 @default.
• W1997162550 crossrefType "journal-article" @default.
• W1997162550 hasAuthorship W1997162550A5012796989 @default.
• W1997162550 hasAuthorship W1997162550A5049051702 @default.
• W1997162550 hasAuthorship W1997162550A5052566514 @default.
• W1997162550 hasAuthorship W1997162550A5066013303 @default.
• W1997162550 hasAuthorship W1997162550A5075212481 @default.
• W1997162550 hasAuthorship W1997162550A5083690640 @default.
• W1997162550 hasBestOaLocation W19971625501 @default.
• W1997162550 hasConcept C104317684 @default.
• W1997162550 hasConcept C105580179 @default.
• W1997162550 hasConcept C137061746 @default.
• W1997162550 hasConcept C138885662 @default.
• W1997162550 hasConcept C142724271 @default.
• W1997162550 hasConcept C153911025 @default.
• W1997162550 hasConcept C159047783 @default.
• W1997162550 hasConcept C179926584 @default.
• W1997162550 hasConcept C202751555 @default.
• W1997162550 hasConcept C203014093 @default.
• W1997162550 hasConcept C2775934546 @default.
• W1997162550 hasConcept C2775938904 @default.
• W1997162550 hasConcept C41895202 @default.
• W1997162550 hasConcept C4692481 @default.
• W1997162550 hasConcept C48023723 @default.
• W1997162550 hasConcept C54355233 @default.
• W1997162550 hasConcept C71924100 @default.
• W1997162550 hasConcept C86803240 @default.
• W1997162550 hasConceptScore W1997162550C104317684 @default.
• W1997162550 hasConceptScore W1997162550C105580179 @default.
• W1997162550 hasConceptScore W1997162550C137061746 @default.
• W1997162550 hasConceptScore W1997162550C138885662 @default.
• W1997162550 hasConceptScore W1997162550C142724271 @default.
• W1997162550 hasConceptScore W1997162550C153911025 @default.
• W1997162550 hasConceptScore W1997162550C159047783 @default.
• W1997162550 hasConceptScore W1997162550C179926584 @default.
• W1997162550 hasConceptScore W1997162550C202751555 @default.
• W1997162550 hasConceptScore W1997162550C203014093 @default.
• W1997162550 hasConceptScore W1997162550C2775934546 @default.
• W1997162550 hasConceptScore W1997162550C2775938904 @default.
• W1997162550 hasConceptScore W1997162550C41895202 @default.
• W1997162550 hasConceptScore W1997162550C4692481 @default.
• W1997162550 hasConceptScore W1997162550C48023723 @default.
• W1997162550 hasConceptScore W1997162550C54355233 @default.
• W1997162550 hasConceptScore W1997162550C71924100 @default.
• W1997162550 hasConceptScore W1997162550C86803240 @default.
• W1997162550 hasLocation W19971625501 @default.
• W1997162550 hasLocation W19971625502 @default.
• W1997162550 hasLocation W19971625503 @default.
• W1997162550 hasLocation W19971625504 @default.
• W1997162550 hasOpenAccess W1997162550 @default.
• W1997162550 hasPrimaryLocation W19971625501 @default.
• W1997162550 hasRelatedWork W2027081658 @default.
• W1997162550 hasRelatedWork W2041114857 @default.
• W1997162550 hasRelatedWork W2159843378 @default.

• next