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- W1997172016 abstract "The influence of removal of the lateral eyes and the pineal gland and the action of melatonin on the synthesis of testosterone and androstenedione from labelled precursors by rat testicular tissue in vitro has been examined. The effects of blinding on steroidogenesis from H 3 -labelled cholesterol and pregnenolone were slight and insignificant but caused significant reduction in the conversion of androstenedione to testosterone. On the other hand, pinealectomy was effective in stimulating testosterone and androstenedione production from cholesterol and pregnenolone but was without significant effect upon androstenedione-testosterone interconversion, except in blinded animals. The addition of melatonin to incubations inhibited androgen formation from pregnenolone and, at the higher level of concentration, favoured androstenedione at the expense of testosterone. The results further illustrate the inhibitory nature of the pineal gland towards testicular function in the rat and support the concept of direct action of pineal components on testicular steroidogenesis in addition to the established pituitary gonadotrophin mediated pineal-gonadal relations." @default.
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- W1997172016 date "1971-01-01" @default.
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- W1997172016 title "Testicular steroidogenesis in vitro in the rat in response to blinding, pinealectomy and to the addition of melatonin" @default.
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- W1997172016 doi "https://doi.org/10.1016/s0039-128x(71)80128-9" @default.
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