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- W1997172643 abstract "To study the role of ischemia due to low perfusion as the inciter of neovascularization, caudally based 3 x 9 cm skin flaps were created on the dorsum of 50 Sprague-Dawley rats. After injection of 0.2 ml 10% fluorescein, the animals were divided into two groups. In group I (n = 25), the distal margin of the flap tip was 1 cm proximal to the border of the fluorescence (good perfusion). In group II (n = 25), the flap was cut 1 cm distally in the nonfluorescent part (poor perfusion). The tips of the cubed flaps were transferred to a wound bed on the right flank. After 10 days, the pedicles were ligated, so that flap survival depended totally on the new vascular supply from the inset area of the flap. The flaps in group I showed a significantly higher rate of necrosis of 52.4 ± 15.1 percent versus 1.7 ± 1.4 percent in group II (P < 0.0001), although the flap length in group I (5.85 ± 1.16 cm) was less than in group II (7.15 ± 0.95 cm; p = 0.0001). A nearly three times larger amount of tissue based on the new blood supply survived in group II compared to group I. Xerograms after injection of PbO2-gelatine on day 10 showed an increased ingrowth of blood vessels in group II. After excluding the delay phenomenon as the cause for the difference in necrosis rate, it is concluded that the only possible explanation is an enhancement of neovascularization by a perfusion gradient between the wound margins." @default.
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- W1997172643 date "1987-12-01" @default.
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- W1997172643 title "Enhanced Neovascularization of Rat Tubed Pedicle Flaps with Low Perfusion of the Wound Margin" @default.
- W1997172643 doi "https://doi.org/10.1097/00006534-198712000-00010" @default.
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