FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1997180266> ?p ?o ?g. }

• W1997180266 endingPage "159" @default.
• W1997180266 startingPage "147" @default.
• W1997180266 abstract "The nuclear vitamin D receptor (VDR) modulates gene transcription in 1,25-dihydroxyvitamin D3 (1,25D) target tissues such as kidney, intestine, and bone. VDR is also expressed in heart, and 1,25D deficiency may play a role in the acceleration of cardiovascular disease. Employing a yeast two-hybrid system and a human heart library, using both a 1,25D-independent and 1,25D-dependent screen, we discovered six candidate VDR interacting proteins (VIPs). These novel VIPs include CXXC5, FASTK, NR4A1, TPM2, MYL3 and XIRP1. Mammalian two-hybrid assays as well as GST pull-downs were used to confirm VIP–VDR interaction, and the combination of these two assays reveals that CXXC5, XIRP1, FASTK and NR4A1 interactions with VDR may be modulated by 1,25D. The functional effects of these VIPs on 1,25D-mediated gene expression were explored in transcriptional assays employing three separate and distinct 1,25D-responsive element (VDRE)-driven luciferase reporter genes in transfected Caco-2 and HEK-293 cells, and in a C2C12 myoblast line. FASTK and TPM2 activated expression in all cell line and promoter contexts, while CXXC5 and XIRP1 exhibited differing effects depending on the cell line and promoter employed, suggesting promoter and cell-specific effects of these unique VIPs on VDR signaling. Further evaluation of the interaction between CXXC5 and VDR revealed that CXXC5 acts in a dose-dependent manner to stimulate VDR-mediated transcription on select VDREs. Identification of novel heart VIPs and their influence on VDR activity may increase our understanding of how vitamin D impacts cardiac physiology and may facilitate development of VDR/VIP drug analogs to combat heart disease." @default.
• W1997180266 created "2016-06-24" @default.
• W1997180266 creator A5024045768 @default.
• W1997180266 creator A5045810940 @default.
• W1997180266 creator A5046892542 @default.
• W1997180266 creator A5058484657 @default.
• W1997180266 creator A5060086357 @default.
• W1997180266 creator A5063654103 @default.
• W1997180266 creator A5072615468 @default.
• W1997180266 date "2012-10-01" @default.
• W1997180266 modified "2023-10-15" @default.
• W1997180266 title "Discovery of novel vitamin D receptor interacting proteins that modulate 1,25-dihydroxyvitamin D3 signaling" @default.
• W1997180266 cites W1257832338 @default.
• W1997180266 cites W1567074636 @default.
• W1997180266 cites W1964616785 @default.
• W1997180266 cites W1969973975 @default.
• W1997180266 cites W1971227936 @default.
• W1997180266 cites W1971657931 @default.
• W1997180266 cites W1972300087 @default.
• W1997180266 cites W1978746967 @default.
• W1997180266 cites W1979313495 @default.
• W1997180266 cites W1984417237 @default.
• W1997180266 cites W1984593949 @default.
• W1997180266 cites W1986061535 @default.
• W1997180266 cites W1986388219 @default.
• W1997180266 cites W1994422321 @default.
• W1997180266 cites W2002030208 @default.
• W1997180266 cites W2009691901 @default.
• W1997180266 cites W2011121985 @default.
• W1997180266 cites W2019757555 @default.
• W1997180266 cites W2023321375 @default.
• W1997180266 cites W2023373433 @default.
• W1997180266 cites W2030640098 @default.
• W1997180266 cites W2034816834 @default.
• W1997180266 cites W2038687690 @default.
• W1997180266 cites W2040429776 @default.
• W1997180266 cites W2044576782 @default.
• W1997180266 cites W2054324871 @default.
• W1997180266 cites W2069321561 @default.
• W1997180266 cites W2069784660 @default.
• W1997180266 cites W2079319826 @default.
• W1997180266 cites W2083978688 @default.
• W1997180266 cites W2088432741 @default.
• W1997180266 cites W2089822623 @default.
• W1997180266 cites W2090210396 @default.
• W1997180266 cites W2090918556 @default.
• W1997180266 cites W2105933042 @default.
• W1997180266 cites W2108825111 @default.
• W1997180266 cites W2109649607 @default.
• W1997180266 cites W2111189459 @default.
• W1997180266 cites W2115391301 @default.
• W1997180266 cites W2120649740 @default.
• W1997180266 cites W2123552387 @default.
• W1997180266 cites W2128252687 @default.
• W1997180266 cites W2129445849 @default.
• W1997180266 cites W2129555025 @default.
• W1997180266 cites W2136650462 @default.
• W1997180266 cites W2138153315 @default.
• W1997180266 cites W2138323080 @default.
• W1997180266 cites W2140843995 @default.
• W1997180266 cites W2142360968 @default.
• W1997180266 cites W2142714456 @default.
• W1997180266 cites W2145038749 @default.
• W1997180266 cites W2146962006 @default.
• W1997180266 cites W2147397909 @default.
• W1997180266 cites W2148299833 @default.
• W1997180266 cites W2148873853 @default.
• W1997180266 cites W2149849198 @default.
• W1997180266 cites W2153942370 @default.
• W1997180266 cites W2163789582 @default.
• W1997180266 doi "https://doi.org/10.1016/j.jsbmb.2012.05.001" @default.
• W1997180266 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3408799" @default.
• W1997180266 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22626544" @default.
• W1997180266 hasPublicationYear "2012" @default.
• W1997180266 type Work @default.
• W1997180266 sameAs 1997180266 @default.
• W1997180266 citedByCount "21" @default.
• W1997180266 countsByYear W19971802662013 @default.
• W1997180266 countsByYear W19971802662014 @default.
• W1997180266 countsByYear W19971802662015 @default.
• W1997180266 countsByYear W19971802662016 @default.
• W1997180266 countsByYear W19971802662018 @default.
• W1997180266 countsByYear W19971802662019 @default.
• W1997180266 countsByYear W19971802662020 @default.
• W1997180266 countsByYear W19971802662021 @default.
• W1997180266 countsByYear W19971802662022 @default.
• W1997180266 crossrefType "journal-article" @default.
• W1997180266 hasAuthorship W1997180266A5024045768 @default.
• W1997180266 hasAuthorship W1997180266A5045810940 @default.
• W1997180266 hasAuthorship W1997180266A5046892542 @default.
• W1997180266 hasAuthorship W1997180266A5058484657 @default.
• W1997180266 hasAuthorship W1997180266A5060086357 @default.
• W1997180266 hasAuthorship W1997180266A5063654103 @default.
• W1997180266 hasAuthorship W1997180266A5072615468 @default.
• W1997180266 hasBestOaLocation W19971802662 @default.
• W1997180266 hasConcept C104317684 @default.
• W1997180266 hasConcept C138885662 @default.
• W1997180266 hasConcept C153911025 @default.

• next