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• W1997184413 abstract "Despite improvement in the understanding of antibiotic-resistance mechanisms, measures to control such resistance have not been uniformly successful. One reason is that these measures have been based on false premises. The most pervasive antibiotic myth is the notion that antibiotic resistance is inevitable if an antibiotic is used in sufficient volume over time. Antibiotics such as doxycycline or nitrofurantoin have been used in high volume for decades without bacteria becoming resistant to them. 1 Levy SB Antibiotic resistance: origins, evolution, selection, and spread. John Wiley & Sons, New York1997: 1-239 Google Scholar , 2 Shlaes DM Gerding DN John Jr, JF et al. Society for Healthcare Epidemiology of American and Infectious Diseases Society of America Joint Committee on the Prevention of Antimicrobial Resistance: guidelines for the prevention of antimicrobial resistance in hospitals. Clin Infect Dis. 1997; 25: 584-599 Crossref PubMed Scopus (534) Google Scholar , 3 Gross PA The potential for clinical guidelines to impact appropriate antimicrobial use. Infect Dis Clin North Am. 1997; 11: 803-812 Summary Full Text Full Text PDF PubMed Scopus (27) Google Scholar The notion that volume of use is associated with resistance lay behind the study reported by Vivre Enne and colleagues in today's Lancet. They investigated whether a national restriction on sulphonamide prescribing reduced incidence of sulphonamide-resistant Escherichia coli-and found no reduction in resistance. Measures to reduce “antibiotic tonnage” by limiting, or avoiding, antimicrobial therapy for viral, non-antibiotic-responsive infections, and non-infectious diseases is good medicine, but does not reduce antibiotic resistance. 1 Levy SB Antibiotic resistance: origins, evolution, selection, and spread. John Wiley & Sons, New York1997: 1-239 Google Scholar Persistence of sulphonamide resistance in Escherichia coli in the UK despite national prescribing restrictionThese results show that a huge decrease in antibiotic prescribing does not necessarily reduce resistance within a useful time. The main reason seems to be the genetic linkage of the index resistance to other resistance determinants. Full-Text PDF" @default.
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• W1997184413 date "2001-04-01" @default.
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• W1997184413 title "Effective antibiotic-resistance control strategies" @default.
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• W1997184413 doi "https://doi.org/10.1016/s0140-6736(00)04527-x" @default.
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