FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1997185399> ?p ?o ?g. }

• W1997185399 endingPage "692" @default.
• W1997185399 startingPage "685" @default.
• W1997185399 abstract "As part of our research efforts in the area of titanium-based antitumor agents, we have investigated the cytotoxic activity of [Ti4(maltolato)8(μ-O)4], (Cp-R)2TiCl2 and (Cp-R)CpTiCl2 (R = CO2CH3 and CO2CH2CH3), and three water-soluble titanocene–amino acid complexes—[Cp2Ti(aa)2]Cl2 (aa = l-cysteine, l-methionine, and d-penicillamine)—on the human colon adenocarcinoma cell line, HT-29. The capacity of [Ti4(maltolato)8(μ-O)4] to donate Ti(IV) to human apo-transferrin and its hydrolytic stability have been investigated and compared to the previously reported data on modified titanocenes with either hydrophilic ancillary ligands or the functionalized cyclopentadienyl ligands. Notably, the titanium–maltolato complex does not transfer Ti(VI) to human apo-transferrin at any time within the first seven days of its interaction, demonstrating the inert character of this species. Stability studies on these complexes have shown that titanocene complexes decompose at physiological pH while the [Ti4(maltolato)8(μ-O)4] complex is stable at this pH without any notable decomposition for a period of ten days. The antitumor activity of these complexes against colon cancer HT-29 cells was determined using an MTT cell viability assay at 72 and 96 h. The titanocene–amino acid and the (Cp-R)2TiCl2/(Cp-R)CpTiCl2 (R = CO2CH3) complexes were not biologically active when human transferrin was absent; they also were inactive when human transferrin was present at dose-equivalent concentrations. (Cp-R)2TiCl2 and (Cp-R)CpTiCl2 (R = CO2CH2CH3) showed cytotoxic activity in HT-29 cells comparable to that which is displayed by titanocene dichloride. The titanium–maltolato complex had higher levels of cytotoxic activity than any other titanocene complex investigated. Transferrin may be important in protecting the titanium center from hydrolysis, but this may be achieved by selecting ligands that could result in hydrolytically stable, yet active, complexes." @default.
• W1997185399 created "2016-06-24" @default.
• W1997185399 creator A5003651633 @default.
• W1997185399 creator A5060897754 @default.
• W1997185399 creator A5065119961 @default.
• W1997185399 creator A5068692430 @default.
• W1997185399 creator A5087399822 @default.
• W1997185399 creator A5091519987 @default.
• W1997185399 date "2008-02-21" @default.
• W1997185399 modified "2023-10-13" @default.
• W1997185399 title "Structure–activity studies of Ti(IV) complexes: aqueous stability and cytotoxic properties in colon cancer HT-29 cells" @default.
• W1997185399 cites W1629179716 @default.
• W1997185399 cites W1966215463 @default.
• W1997185399 cites W1970838505 @default.
• W1997185399 cites W1985276186 @default.
• W1997185399 cites W1991127687 @default.
• W1997185399 cites W1991588605 @default.
• W1997185399 cites W2000537596 @default.
• W1997185399 cites W2003538432 @default.
• W1997185399 cites W2005354443 @default.
• W1997185399 cites W2006325254 @default.
• W1997185399 cites W2015694743 @default.
• W1997185399 cites W2019724950 @default.
• W1997185399 cites W2030205272 @default.
• W1997185399 cites W2039560945 @default.
• W1997185399 cites W2044330700 @default.
• W1997185399 cites W2056720623 @default.
• W1997185399 cites W2062020376 @default.
• W1997185399 cites W2074888759 @default.
• W1997185399 cites W2083484180 @default.
• W1997185399 cites W2083526260 @default.
• W1997185399 cites W2102518708 @default.
• W1997185399 cites W2104956085 @default.
• W1997185399 cites W2107828528 @default.
• W1997185399 cites W2113116917 @default.
• W1997185399 cites W2114918609 @default.
• W1997185399 cites W2155998244 @default.
• W1997185399 cites W2168940441 @default.
• W1997185399 cites W2169423202 @default.
• W1997185399 cites W2288093942 @default.
• W1997185399 cites W3004576110 @default.
• W1997185399 cites W4235884583 @default.
• W1997185399 doi "https://doi.org/10.1007/s00775-008-0353-z" @default.
• W1997185399 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4461444" @default.
• W1997185399 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18288505" @default.
• W1997185399 hasPublicationYear "2008" @default.
• W1997185399 type Work @default.
• W1997185399 sameAs 1997185399 @default.
• W1997185399 citedByCount "33" @default.
• W1997185399 countsByYear W19971853992012 @default.
• W1997185399 countsByYear W19971853992014 @default.
• W1997185399 countsByYear W19971853992015 @default.
• W1997185399 countsByYear W19971853992016 @default.
• W1997185399 countsByYear W19971853992017 @default.
• W1997185399 countsByYear W19971853992020 @default.
• W1997185399 countsByYear W19971853992021 @default.
• W1997185399 countsByYear W19971853992022 @default.
• W1997185399 countsByYear W19971853992023 @default.
• W1997185399 crossrefType "journal-article" @default.
• W1997185399 hasAuthorship W1997185399A5003651633 @default.
• W1997185399 hasAuthorship W1997185399A5060897754 @default.
• W1997185399 hasAuthorship W1997185399A5065119961 @default.
• W1997185399 hasAuthorship W1997185399A5068692430 @default.
• W1997185399 hasAuthorship W1997185399A5087399822 @default.
• W1997185399 hasAuthorship W1997185399A5091519987 @default.
• W1997185399 hasBestOaLocation W19971853992 @default.
• W1997185399 hasConcept C154317977 @default.
• W1997185399 hasConcept C155647269 @default.
• W1997185399 hasConcept C161790260 @default.
• W1997185399 hasConcept C181458950 @default.
• W1997185399 hasConcept C185592680 @default.
• W1997185399 hasConcept C202751555 @default.
• W1997185399 hasConcept C22814914 @default.
• W1997185399 hasConcept C2780783641 @default.
• W1997185399 hasConcept C2780912031 @default.
• W1997185399 hasConcept C515207424 @default.
• W1997185399 hasConcept C55493867 @default.
• W1997185399 hasConcept C71240020 @default.
• W1997185399 hasConceptScore W1997185399C154317977 @default.
• W1997185399 hasConceptScore W1997185399C155647269 @default.
• W1997185399 hasConceptScore W1997185399C161790260 @default.
• W1997185399 hasConceptScore W1997185399C181458950 @default.
• W1997185399 hasConceptScore W1997185399C185592680 @default.
• W1997185399 hasConceptScore W1997185399C202751555 @default.
• W1997185399 hasConceptScore W1997185399C22814914 @default.
• W1997185399 hasConceptScore W1997185399C2780783641 @default.
• W1997185399 hasConceptScore W1997185399C2780912031 @default.
• W1997185399 hasConceptScore W1997185399C515207424 @default.
• W1997185399 hasConceptScore W1997185399C55493867 @default.
• W1997185399 hasConceptScore W1997185399C71240020 @default.
• W1997185399 hasIssue "5" @default.
• W1997185399 hasLocation W19971853991 @default.
• W1997185399 hasLocation W19971853992 @default.
• W1997185399 hasLocation W19971853993 @default.
• W1997185399 hasLocation W19971853994 @default.
• W1997185399 hasOpenAccess W1997185399 @default.
• W1997185399 hasPrimaryLocation W19971853991 @default.
• W1997185399 hasRelatedWork W1981403632 @default.

• next